Transplant News and Research

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University of Maryland surgeons transplant first lungs treated with experimental repair process

Surgeons at the University of Maryland Medical Center have transplanted the first lungs treated in the United States with an experimental repair process before transplantation. The procedure is part of a five-center national clinical research trial to evaluate the efficacy of repairing, before transplant, lungs that might otherwise have been passed over as unsuitable for organ donation.

8 Sep 2011

Legal, ethical and cultural barriers to child organ donations

Clinicians from a leading UK children's hospital have called for European countries to change the way they tackle the shortage of organ donations from children, after a review, published in the September issue of Acta Paediatrica, found a large number of legal, ethical and cultural barriers.

8 Sep 2011

EC grants orphan drug status for Santen's sirolimus to treat chronic non-infectious uveitis

Santen Inc., the U.S. subsidiary of global ophthalmic pharmaceutical company Santen Pharmaceutical Co., Ltd. today announced the European Commission (EC) has granted orphan drug status for sirolimus (DE-109) for the treatment of chronic non-infectious uveitis.

From Santen Pharmaceutical Co., Ltd. 8 Sep 2011

Rep. Berkley's efforts on kidney program questioned

At the University Medical Center in Las Vegas, alarms were set off three years ago -; kidney transplants were failing at unusually high rates ... Federal regulators moved to shut down the kidney transplant program.

7 Sep 2011

Researchers use ultrasound to improve quality of blood stem cell transplant

Transplantation of haematopoietic stem cells is an effective treatment for patients with malignant blood diseases. The composition and quality of the transplanted cells are crucial to the outcome. Researchers from Lund University, Sweden, have now developed a method to improve the quality of the transplanted cells using ultrasound for cell separation.

7 Sep 2011

Brown fat may help curb obesity: Study

Australian scientists have pioneered a way to grow in the laboratory “brown fat” - a wondrous tissue that burns energy to generate heat - a breakthrough which they claim could be the latest weapon in the battle against obesity.

6 Sep 2011

First Edition: September 6, 2011

Today's early morning highlights from the major news organizations include reports from a GOP presidential candidate forum in South Carolina and analysis of what to expect as Congress returns to Washington.

6 Sep 2011

Researchers discover new genetic defect that predisposes people to leukemia, myelodysplasia

A new genetic defect that predisposes people to acute myeloid leukemia and myelodysplasia has been discovered. The mutations were found in the GATA2 gene. Among its several regulatory roles, the gene acts as a master control during the transition of primitive blood-forming cells into white blood cells.

5 Sep 2011

Researchers inject cultured red blood cells created from HSCs into human donor

For the first time, researchers have successfully injected cultured red blood cells (cRBCs) created from human hematopoietic stem cells (HSCs) into a human donor, according to study results published today in Blood, the Journal of the American Society of Hematology.

3 Sep 2011

Loyola surgeons use new, less invasive catheter technique to treat cystic fibrosis

Cystic fibrosis patient Daniel Sammons had undergone a successful double lung transplant at Loyola University Medical Center, but he still had one major health issue.

3 Sep 2011

Plerixafor drug shows promise against WHIM syndrome

A new study reports that a drug already approved by the Food and Drug Administration for use in patients undergoing a bone marrow transplant may also have promise for treating people who have a rare immune deficiency known as WHIM syndrome.

3 Sep 2011

Jefferson's two-step bone marrow transplant procedure holds promise for cancer patients

Half-matched bone marrow or stem cell transplants for blood cancer patients have typically been associated with disappointing clinical outcomes. However, a clinical trial conducted at the Kimmel Cancer Center at Jefferson testing its unique, two-step half-match procedure has produced some promising results: the probability of overall survival was 45 percent in all patients after three years and 75 percent in patients who were in remission at the time of the transplant.

2 Sep 2011

More strides against childhood cancer

The treatment of childhood cancer is one of the great success stories of modern medicine. A few decades ago, only 20 percent of children survived the disease. Today, overall survival rates approach 80 percent. Yet cancer remains the leading cause of death from disease in U.S. children older than 1 year of age, and some types of pediatric cancer continue to have poor survival rates.

2 Sep 2011

New tool to predict survival after heart transplant

Johns Hopkins researchers say they have developed a formula to predict which heart transplant patients are at greatest risk of death in the year following their surgeries, information that could help medical teams figure out who would benefit most from the small number of available organs.

2 Sep 2011

New clinical data on Bristol-Myers Squibb's NULOJIX to be presented at ESOT 2011 congress

Bristol-Myers Squibb Company today announced that new data on NULOJIX (belatacept) will be presented at the European Society for Organ Transplantation (ESOT) Congress on September 4 -7, 2011 in Glasgow, Scotland, United Kingdom.

2 Sep 2011

SAIC awards Selecta a subcontract to develop synthetic nanoparticle vaccine for malaria

Selecta Biosciences, Inc., a biopharmaceutical company developing an entirely new class of targeted vaccines and immunotherapies, today announced that Science Applications International Corporation (SAIC) has awarded Selecta a subcontract to develop a targeted synthetic vaccine particle product for malaria.

31 Aug 2011

Postoperative outcomes of VAD bridged patients are worse than conventional therapy

Postoperative outcomes of severe heart failure patients bridged with short-term VADs to urgent heart transplantation are significantly worse than those of patients bridged with conventional support, recent data of the Spanish National Heart Transplant Registry suggest.

30 Aug 2011

High risk of serious complications or death in children with SP-HUS

Hemolytic uremic syndrome (HUS) caused by infection with pneumococcal bacteria leads to severe illness—with a high rate of irreversible kidney damage—in infants and young children, reports a study in the September issue of The Pediatric Infectious Disease Journal.

30 Aug 2011

UT Southwestern surgeons to perform first hand transplant in North Texas

A team of surgeons at UT Southwestern Medical Center expects to perform the first hand transplant in North Texas within a year, making the institution just the sixth hospital in the U.S. to perform the rare and intricate surgery.

30 Aug 2011

U-M offers transplantation for patients with bile duct cancer

Robert "Buzz" Gehle thought the itchy rash he was experiencing was a recurrence of an earlier case of shingles. But when his doctor saw he was also jaundiced, he immediately knew there was a problem with Gehle's liver.

30 Aug 2011

Transplant News and Research

University of Maryland surgeons transplant first lungs treated with experimental repair process

Legal, ethical and cultural barriers to child organ donations

EC grants orphan drug status for Santen's sirolimus to treat chronic non-infectious uveitis

Rep. Berkley's efforts on kidney program questioned

Researchers use ultrasound to improve quality of blood stem cell transplant

Brown fat may help curb obesity: Study

First Edition: September 6, 2011

Researchers discover new genetic defect that predisposes people to leukemia, myelodysplasia

Researchers inject cultured red blood cells created from HSCs into human donor

Loyola surgeons use new, less invasive catheter technique to treat cystic fibrosis

Plerixafor drug shows promise against WHIM syndrome

Jefferson's two-step bone marrow transplant procedure holds promise for cancer patients

More strides against childhood cancer

New tool to predict survival after heart transplant

New clinical data on Bristol-Myers Squibb's NULOJIX to be presented at ESOT 2011 congress

SAIC awards Selecta a subcontract to develop synthetic nanoparticle vaccine for malaria

Postoperative outcomes of VAD bridged patients are worse than conventional therapy

High risk of serious complications or death in children with SP-HUS

UT Southwestern surgeons to perform first hand transplant in North Texas

U-M offers transplantation for patients with bile duct cancer

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