Messenger RNA (mRNA) News and Research

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Allele’s scientists describe important advance in generation of human stem cells

This week in the journal Scientific Reports, scientists from Allele Biotechnology describe an important advance in the generation of stem cells capable of producing all the different tissues of the human body.

15 Sep 2012

Molecular beacons allow scientists to monitor gene expression during stem cell transformation

A novel set of custom-designed "molecular beacons" allows scientists to monitor gene expression in living populations of stem cells as they turn into a specific tissue in real-time. The technology, which Brown University researchers describe in a new study, provides tissue engineers with a potentially powerful tool to discover what it may take to make stem cells transform into desired tissue cells more often and more quickly.

12 Sep 2012

Yale University professor receives 2012 Vanderbilt Prize in Biomedical Science

The 2012 Vanderbilt Prize in Biomedical Science has been awarded to Yale University professor Joan Steitz, Ph.D., whose pioneering work has helped reveal and clarify the complexities of RNA and the roles that RNA molecules play in health and disease.

11 Sep 2012

RNA researcher to receive 2012 Pearl Meister Greengard Prize from The Rockefeller University

Joan A. Steitz, Ph.D., a pioneer in the field of RNA biology whose discoveries involved patients with a variety of autoimmune diseases, will be awarded the 2012 Pearl Meister Greengard Prize from The Rockefeller University. The prize, which honors female scientists who have made extraordinary contributions to biomedical science and carries an honorarium of $100,000, will be presented at a ceremony on Thursday, November 29 at Rockefeller University's Caspary Auditorium.

11 Sep 2012

Scientists characterize the lung squamous cell carcinoma genome

In the September 9, 2012 early online edition of Nature, scientists with The Cancer Genome Atlas (TCGA) report that they have characterized the lung squamous cell carcinoma genome.

10 Sep 2012

LIN28 protein can bind directly to thousands of messenger RNAs

A study led by researchers at the UC San Diego Stem Cell Research program and funded by the California Institute for Regenerative Medicine (CIRM) looks at an important RNA binding protein called LIN28, which is implicated in pluripotency and reprogramming as well as in cancer and other diseases.

6 Sep 2012

Scientists show how pluripotent stem cells mobilize in wounded planarian worms

The skin, the blood, and the lining of the gut-adult stem cells replenish them daily. But stem cells really show off their healing powers in planarians, humble flatworms fabled for their ability to rebuild any missing body part. Just how adult stem cells build the right tissues at the right times and places has remained largely unanswered.

1 Sep 2012

Quest Diagnostics announces availability of TERC test for cervical cancer

Quest Diagnostics, the world's leading provider of diagnostic testing, information and services, today announced the availability of a new laboratory test that identifies molecular changes to cervical cells that increase the likelihood a woman may develop cervical cancer.

From Quest Diagnostics 31 Aug 2012

New blood test can predict which heart failure patients would benefit from ICDs

A novel blood test that predicts sudden death risk in heart failure patients is set to help physicians decide which patients would benefit from implantable cardioverter defibrillators (ICDs).

27 Aug 2012

New results describe development of DC cancer vaccine with enhanced immunogenic potential

Alnylam Pharmaceuticals, Inc., a leading RNAi therapeutics company, and collaborators at Radboud University Nijmegen Medical Centre in the Netherlands announced today that they have published new pre-clinical results in the journal Cancer Immunology Immunotherapy describing the development of a dendritic cell (DC) cancer vaccine with enhanced immunogenic potential.

23 Aug 2012

RNA switches can better equip and regulate viruses for many therapeutic applications

Numerous viruses are used in the service of science today. They serve as gene taxis to transfer therapeutic genes into body cells or as therapeutic viruses targeted to infect and destroy cancer cells. For such applications, the viruses are often equipped with additional genes, such as for immune mediators or for proteins inducing programmed cell death. However, these gene products can harm the body if they are released at the wrong moment or at excessive levels.

22 Aug 2012

Chemists develop new lab test to examine how DNA damage disrupts protein synthesis

Transcription is a cellular process by which genetic information from DNA is copied to messenger RNA for protein production. But anticancer drugs and environmental chemicals can sometimes interrupt this flow of genetic information by causing modifications in DNA.

22 Aug 2012

RNA-delivering nanoparticles allow rapid screening of new drug targets in mice

By sequencing cancer-cell genomes, scientists have discovered vast numbers of genes that are mutated, deleted or copied in cancer cells. This treasure trove is a boon for researchers seeking new drug targets, but it is nearly impossible to test them all in a timely fashion.

16 Aug 2012

Scientists reveal how TREX proteins act as passport for transfer of cell blueprints

Decoded process could hold the key to future treatments for a wide range of chronic health problems including Motor Neuron Disease, myotonic dystrophy and a wide range of cancers, University of Sheffield scientists have revealed.

16 Aug 2012

Antisense therapy shows promise in treating toxoplasmosis

A targeted approach to treating toxoplasmosis, a parasitic disease, shows early promise in test-tube and animal studies, where it prevented the parasites from making selected proteins. When tested in newly infected mice, it reduced the number of viable parasites by more than 90 percent, researchers from the University of Chicago Medicine report in the Proceedings of the National Academy of Sciences.

14 Aug 2012

Ingredient for butter flavor in microwave popcorn is a respiratory hazard

The ingredient 2,3-pentanedione (PD), used to impart the flavor and aroma of butter in microwave popcorn, is a respiratory hazard that can also alter gene expression in the brain of rats. Manufacturers started using PD when another butter flavoring, diacetyl, was found to cause bronchiolitis obliterans, a life-threatening and nonreversible lung disease in workers who inhaled the substance.

13 Aug 2012

Drug molecules designed for influenza may be adapted to treat other viruses

St. Jude Children's Research Hospital study shows how compounds blocking an enzyme universal to all influenza viruses may allow development of new antiviral drugs that also avoid the problem of drug resistance

3 Aug 2012

Anacardic acid can rescue some ALS phenotypes in vitro

A research group at the Center for iPS Cell Research and Application (CiRA) at Japan's Kyoto University has successfully recapitulated amyotrophic lateral sclerosis (ALS)-associated abnormalities in motor neurons differentiated from induced pluripotent stem cells (iPSCs) obtained from patients with familial ALS, a late-onset, fatal disorder which is also known for Lou Gehrig's disease. In a drug screening assay using the disease model, the team further found that the chemical compound anacardic acid can rescue some ALS phenotypes in vitro.

3 Aug 2012

Myc-directed repression of tristetraprolin important for development and maintenance of cancer

Scientists from the Florida campus of The Scripps Research Institute have identified a protein that impairs the development and maintenance of lymphoma (cancer of the lymph nodes), but is repressed during the initial stages of the disease, allowing for rapid tumor growth.

3 Aug 2012

New research indicates molecular signaling from end to end in peripheral nerve cells

When the longest cells in the body are injured at their farthest reaches, coordinating the cells' repair is no easy task. This is in part because these peripheral nerve cells can be extremely long - up to one meter in adult humans - which is a lot of distance for a molecular distress signal to cover in order to reach the "command center" of the cell's nucleus.

30 Jul 2012

Messenger RNA (mRNA) News and Research

Allele’s scientists describe important advance in generation of human stem cells

Molecular beacons allow scientists to monitor gene expression during stem cell transformation

Yale University professor receives 2012 Vanderbilt Prize in Biomedical Science

RNA researcher to receive 2012 Pearl Meister Greengard Prize from The Rockefeller University

Scientists characterize the lung squamous cell carcinoma genome

LIN28 protein can bind directly to thousands of messenger RNAs

Scientists show how pluripotent stem cells mobilize in wounded planarian worms

Quest Diagnostics announces availability of TERC test for cervical cancer

New blood test can predict which heart failure patients would benefit from ICDs

New results describe development of DC cancer vaccine with enhanced immunogenic potential

RNA switches can better equip and regulate viruses for many therapeutic applications

Chemists develop new lab test to examine how DNA damage disrupts protein synthesis

RNA-delivering nanoparticles allow rapid screening of new drug targets in mice

Scientists reveal how TREX proteins act as passport for transfer of cell blueprints

Antisense therapy shows promise in treating toxoplasmosis

Ingredient for butter flavor in microwave popcorn is a respiratory hazard

Drug molecules designed for influenza may be adapted to treat other viruses

Anacardic acid can rescue some ALS phenotypes in vitro

Myc-directed repression of tristetraprolin important for development and maintenance of cancer

New research indicates molecular signaling from end to end in peripheral nerve cells

eBook: A guide to RNA sequencing eBook

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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