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Groundbreaking study maps molecular architecture of the visual system's integral components

A groundbreaking study has taken a significant step towards understanding the complexities of the human eye.

4 Jun 2023

Multiple sclerosis: Immune cell invasion enabled by blood-brain barrier breakdown

Blood-brain barrier breakdown in multiple sclerosis leads to immune cell infiltration into the central nervous system. Antigen presentation at the barrier promotes CD8+ T cell entry, triggering focal breakdown and hindering their invasion.

4 Jun 2023

Study offers the most comprehensive archive of cellular, molecular features involved in psoriatic disease

Beneath and beyond the reddish, flaky lesions that form in the skin of those with psoriasis, mild and severe forms of the disease can be told apart by the activity of key cells and signaling pathways, a new study shows.

2 Jun 2023

Study of immunotherapy for brain cancer metastases shows promising results

In a phase 2 clinical trial of the immune checkpoint inhibitor pembrolizumab, investigators found that 42 percent of patients with metastatic brain cancer benefited from the therapy, with seven patients in the trial surviving longer than two years.

2 Jun 2023

Lupus Therapeutics announces three Phase 3 clinical trials testing new therapies for SLE and lupus nephritis

Lupus Therapeutics announced the start of a collaboration to conduct three Phase 3 clinical trials testing an investigational therapeutic ianalumab for systemic lupus erythematosus and lupus nephritis.

2 Jun 2023

Exposure to Agent Orange associated with increased risk of myeloproliferative neoplasms in veterans

Research conducted at Georgetown University's Lombardi Comprehensive Cancer Center and the Washington DC VA Medical Center on a database of veterans exposed to Agent Orange found an association for an increased risk of developing myeloproliferative neoplasms (MPNs), which are acquired stem cell disorders that can lead to overproduction of mature blood cells complicated by an increased risk of blood clots in arteries and veins.

2 Jun 2023

University of Louisville researchers receive $5.8 million to prevent immune system dysregulation

Researchers at the University of Louisville have received $5.8 million in two grants from the National Institutes of Health to expand their work to better understand and prevent immune system dysregulation responsible for acute respiratory distress, the condition responsible for serious illness and death in some COVID-19 patients.

2 Jun 2023

High levels of memory killer cells correlate with better survival in melanoma patients

Our skin contains specialized long-lived killer cells that protect against intruders. Researchers at Karolinska Institutet in Sweden and the University of Copenhagen in Denmark have now identified how these cells are formed, and shown that high levels of memory killer cells in cancer tissue correlate with a better survival rate in people with melanoma.

2 Jun 2023

To what extent does prenatal folate status modify associations between early pregnancy perfluoroalkyl and polyfluoroalkyl substance exposure and birth outcomes?

Researchers evaluated the relationship between PFAS exposure during pregnancy and birth outcomes.

2 Jun 2023

"Sepsis sensors" with magnetic nanoparticles rapidly detect bacterial pathogens

In the case of blood poisoning, the bacteria in the blood must be identified as fast as possible so that a life-saving therapy can be started.

1 Jun 2023

Juicy findings: Chinese consumers embrace fruit peel delights, scientists examine nutritional value and pesticide concerns

Research explores the consumption of fruit peels by Chinese consumers, highlighting their nutritional value and pesticide residues. It provides insights into methods of pesticide detection and removal, as well as the physiological benefits of fruit peels, aiming to guide informed consumption and contribute to further research in this area.

1 Jun 2023

St. Jude researchers discover NLRP12 as a direct bridge from hemolysis to inflammatory disease

Infections and other diseases can cause red blood cells to rupture, releasing the oxygen-binding molecule hemoglobin, which breaks down into heme.

1 Jun 2023

MFAP5, a microfibril-associated protein, unveiled as key player in scar formation and wound healing

MFAP5, a microfibril-associated protein, plays a significant role in wound healing by regulating fibroblast function, collagen deposition, and angiogenesis, suggesting its potential as a modulator of scar formation.

1 Jun 2023

Severe COVID-19 raises alarm for undiagnosed cancer

Severe SARS-CoV-2 infection is associated with a 1.31 higher risk of being diagnosed with cancer following hospital discharge, particularly renal, hematological, colon, and lung cancers, suggesting a potential link between the infection and undiagnosed cancer.

1 Jun 2023

New algorithm could improve the search for genetic cause of hereditary diseases

So far, it has not been possible to explain the causes of around half of all rare hereditary diseases. A Munich research team has developed an algorithm that predicts the effects of genetic mutations on RNA formation six times more precisely than previous models.

1 Jun 2023

Fentanyl could be weaponized and used for terroristic mass poisoning

The widely-available drug fentanyl, already the number one killer of Americans under 50, could be weaponized and used for terroristic mass poisoning, according to health experts at Rutgers and other institutions.

1 Jun 2023

Parkinson's disease drug ropinirole is safe and tolerable for ALS patients, early clinical trial shows

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a fatal motor neuron disease that causes people to gradually lose control of their muscles.

1 Jun 2023

"Deep sequencing" of the genome informs diagnoses and treatment of vascular anomalies

Researchers from Children's Hospital of Philadelphia (CHOP) recently discovered that extremely thorough "deep sequencing" of the genome in tissue samples and cell-free DNA of patients with potentially life-threatening vascular anomalies captured several genetic variants related to disease that were not captured with conventional genetic sequencing methods.

1 Jun 2023

New data guides treatment choices for patients with r/r lymphoma during pregnancy

Today, Blood Advances published a study revealing that patients with relapsed/refractory (r/r) lymphoma during pregnancy experienced a progression-free survival rate of 24% and an overall survival rate of 83%.

1 Jun 2023

Peptidomimetic antibiotics may be effective against resistant bacteria

Health professionals are in urgent need of new antibiotics to tackle resistant bacteria. Researchers at the University of Zurich and the company Spexis have now modified the chemical structure of naturally occurring peptides to develop antimicrobial molecules that bind to novel targets in the bacteria's metabolism.

1 Jun 2023

Blood News and Research

Groundbreaking study maps molecular architecture of the visual system's integral components

Multiple sclerosis: Immune cell invasion enabled by blood-brain barrier breakdown

Study offers the most comprehensive archive of cellular, molecular features involved in psoriatic disease

Study of immunotherapy for brain cancer metastases shows promising results

Lupus Therapeutics announces three Phase 3 clinical trials testing new therapies for SLE and lupus nephritis

Exposure to Agent Orange associated with increased risk of myeloproliferative neoplasms in veterans

University of Louisville researchers receive $5.8 million to prevent immune system dysregulation

High levels of memory killer cells correlate with better survival in melanoma patients

To what extent does prenatal folate status modify associations between early pregnancy perfluoroalkyl and polyfluoroalkyl substance exposure and birth outcomes?

"Sepsis sensors" with magnetic nanoparticles rapidly detect bacterial pathogens

Juicy findings: Chinese consumers embrace fruit peel delights, scientists examine nutritional value and pesticide concerns

St. Jude researchers discover NLRP12 as a direct bridge from hemolysis to inflammatory disease

MFAP5, a microfibril-associated protein, unveiled as key player in scar formation and wound healing

Severe COVID-19 raises alarm for undiagnosed cancer

New algorithm could improve the search for genetic cause of hereditary diseases

Fentanyl could be weaponized and used for terroristic mass poisoning

Parkinson's disease drug ropinirole is safe and tolerable for ALS patients, early clinical trial shows

"Deep sequencing" of the genome informs diagnoses and treatment of vascular anomalies

New data guides treatment choices for patients with r/r lymphoma during pregnancy

Peptidomimetic antibiotics may be effective against resistant bacteria

Decoding Cannabis: Differentiating Hemp and Marijuana

Deciphering the Microbiome with The Microsetta Initiative

Leveraging the power of automation to boost research

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