Lungs News and Research

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Rice University researchers set stage for large-scale synthesis of cytotoxic agent to treat cancer

The lab of Rice University synthetic organic chemist K.C. Nicolaou has reported the streamlined total synthesis of delta12-prostaglandin J3, a molecule previously claimed to kill leukemic cancer cells.

24 May 2016

Breakthrough study observes structural changes in carbonic anhydrase for first time

A new study by an international team of researchers, affiliated with Ulsan National Institute of Science and Technology has announced that they have succeeded for the first time in observing the structural changes in carbonic anhydrase.

24 May 2016

Studies explore possible link between pediatric cancer and light therapy for newborn jaundice

Two new studies raise enough questions about a possible link between childhood cancer and light therapy for newborn jaundice that clinicians should exercise caution in prescribing the treatment for infants whose jaundice is likely to resolve on its own, a pediatric oncologist from Dana-Farber/Boston Children's Cancer and Blood Disorders Center argues in an editorial published today by the journal Pediatrics.

23 May 2016

Investigational drug abemaciclib shows durable clinical activity for variety of cancer types

The investigational anticancer therapeutic abemaciclib, which targets CDK4 and CDK6, showed durable clinical activity when given as continuous single-agent therapy to patients with a variety of cancer types, including breast cancer, non-small cell lung cancer (NSCLC), glioblastoma, and melanoma, according to results from a phase I clinical trial.

23 May 2016

Aggressive blood pressure intervention can benefit frail adults aged 75 and older

NIH-supported researchers are reporting additional details about a widely-publicized study that linked a systolic blood pressure target under 120 mm Hg (millimeters of mercury) with reduced cardiovascular disease and a lower risk of death.

23 May 2016

Cochrane review explores FDCs versus single-drug formulations for treatment of pulmonary TB

A research team from Spain has prepared a Cochrane systematic review that explores the efficacy, safety, and adherence to fixed-dose combinations (FDCs) of drugs versus single-drug formulations to treat people who are newly diagnosed with tuberculosis (TB).

23 May 2016

Inhibiting palmitate-adding enzyme can make cancer cells sensitive to EGFR inhibitors

The mistaken activation of certain cell-surface receptors contributes to a variety of human cancers. Knowing more about the activation process has led researchers to be able to induce greater vulnerability by cancer cells to an existing first-line treatment for cancers (mainly lung) driven by a receptor called EGFR.

23 May 2016

Wresting back control of CHI3L1 protein could stave off cancer spread in mice

For cancer to spread, the cells that take off into the bloodstream must find a tissue that will permit them to thrive. They don't just go looking, though. Instead, they actively prepare the tissue, in one case by co-opting a protein that suppresses defenses the body would otherwise mount.

21 May 2016

Researchers identify hCRTh2 protein as possible therapeutic target for asthma

Patients with asthma have chronic lung inflammation that results in sporadic narrowing of the airways and difficulty breathing. Symptoms and severity are variable among individuals; however, the cells and inflammatory factors that trigger asthmatic events have been fairly well characterized and are similar regardless of the asthma-inducing stimuli.

20 May 2016

AstraZeneca, MedImmune to provide update on extensive oncology pipeline at ASCO 2016

AstraZeneca and its global biologics research and development arm, MedImmune, will provide an update on their extensive oncology pipeline at the annual meeting of the American Society of Clinical Oncology in Chicago, USA, on 3-7 June 2016.

20 May 2016

TAK1 deficit protects mice from obesity

Obesity and subsequent complications are increasing in frequency worldwide. The accumulation of adipose tissue is associated with increased inflammation, and it has been proposed that modification of proinflammatory responses could alter adipose tissue composition.

20 May 2016

Gene editing technology helps excise segment of HIV-1 DNA from genomes of living animals

Using gene editing technology, researchers at the Lewis Katz School of Medicine at Temple University have, for the first time, successfully excised a segment of HIV-1 DNA - the virus responsible for AIDS - from the genomes of living animals.

20 May 2016

Nanoparticle-based gene therapy may hold promise for patients with asthma

A new study has demonstrated a way to deliver a nanoparticle-based gene therapy, in order to repair lungs damaged by chronic allergic asthma and to reduce inflammation that causes asthma attacks.

19 May 2016

Hydroxyurea treatment improves pulmonary function decline in children with sickle cell disease

For the first time, researchers were able to demonstrate that children diagnosed with sickle cell disease showed improvement in lung function after treatment with hydroxyurea, a treatment that is underused despite its demonstrated benefits.

19 May 2016

ICS users may be at greater risk for nontuberculous mycobacteria pulmonary disease

Patients with obstructive lung disease who take inhaled corticosteroids (ICS) may be at greater risk for nontuberculous mycobacteria pulmonary disease (NTM PD), according to new research presented at the ATS 2016 International Conference.

19 May 2016

Tecentriq drug gets FDA approval to treat urothelial carcinoma

The U.S. Food and Drug Administration today approved Tecentriq (atezolizumab) to treat the most common type of bladder cancer, called urothelial carcinoma. This is the first product in its class (PD-1/PD-L1 inhibitors) approved to treat this type of cancer.

19 May 2016

Pocket ultrasound device helps health personnel detect early signs of dehydration or heart failure

Detecting fluid retention in patients early is important to prevent their heart failure from getting worse. Nurses who are trained in the use of handheld pocket ultrasound devices can dispense diuretic drugs more precisely.

18 May 2016

Comprehensive outlook of COPD care in the U.S.

Fifteen million: That's the number of adults in the United States affected by chronic obstructive pulmonary disease, or COPD.

18 May 2016

COPD exacerbations accelerate lung decline

In patients with chronic obstructive pulmonary disease (COPD), exacerbations accelerated lung function loss, according to a new study presented at the ATS 2016 International Conference. The effect was particularly prominent in those with mild disease.

17 May 2016

Study shows half of smokers experience respiratory symptoms similar to COPD

A new study in the New England Journal of Medicine finds that smokers, who wouldn't typically be diagnosed with chronic obstructive pulmonary disease, or COPD, are still showing symptoms consistent with the diagnosis.

17 May 2016

Lungs News and Research

Rice University researchers set stage for large-scale synthesis of cytotoxic agent to treat cancer

Breakthrough study observes structural changes in carbonic anhydrase for first time

Studies explore possible link between pediatric cancer and light therapy for newborn jaundice

Investigational drug abemaciclib shows durable clinical activity for variety of cancer types

Aggressive blood pressure intervention can benefit frail adults aged 75 and older

Cochrane review explores FDCs versus single-drug formulations for treatment of pulmonary TB

Inhibiting palmitate-adding enzyme can make cancer cells sensitive to EGFR inhibitors

Wresting back control of CHI3L1 protein could stave off cancer spread in mice

Researchers identify hCRTh2 protein as possible therapeutic target for asthma

AstraZeneca, MedImmune to provide update on extensive oncology pipeline at ASCO 2016

TAK1 deficit protects mice from obesity

Gene editing technology helps excise segment of HIV-1 DNA from genomes of living animals

Nanoparticle-based gene therapy may hold promise for patients with asthma

Hydroxyurea treatment improves pulmonary function decline in children with sickle cell disease

ICS users may be at greater risk for nontuberculous mycobacteria pulmonary disease

Tecentriq drug gets FDA approval to treat urothelial carcinoma

Pocket ultrasound device helps health personnel detect early signs of dehydration or heart failure

Comprehensive outlook of COPD care in the U.S.

COPD exacerbations accelerate lung decline

Study shows half of smokers experience respiratory symptoms similar to COPD

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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