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Researchers reveal new technique to grow human hepatocytes in the laboratory

In new research appearing in the prestigious journal Nature Biotechnology, an international research team led by The Hebrew University of Jerusalem describes a new technique for growing human hepatocytes in the laboratory. This groundbreaking development could help advance a variety of liver-related research and applications, from studying drug toxicity to creating bio-artificial liver support for patients awaiting transplantations.

27 Nov 2015

‘Zero pressure’ mattress solutions to be showcased at MEDICA 2015

‘Stop the Pressure’ is the message from pressure ulcer specialist Rober, who is showcasing their wide range of innovative mattresses in support of Worldwide STOP Pressure Ulcer Day at MEDICA 2015, the world’s largest healthcare technology exhibition.

4 Nov 2015

Blood stem cell self-renewal dependent on surroundings

Stem cells have two important capabilities: they can develop into a wide range of cell types and simultaneously renew themselves, creating fresh stem cells. Using a model of the blood forming (hematopoietic) system, researchers at the Technical University of Munich (TUM) have now been able to precisely determine, which signaling pathways play an essential role in the self-renewal of blood stem cells. A particularly decisive role in this process is the interactive communication with surrounding tissue cells in the bone marrow.

3 Nov 2015

Targeting invasive cells could be a new strategy to treat metastatic cancer, say Stony Brook researchers

Most cancer drugs are designed to target dividing cells, but a new study by Stony Brook University researchers suggests that targeting invasive cells may be a new strategy to treat metastatic cancer.

27 Oct 2015

Active nuclear deformations contribute to formation of intra-nuclear chromosome architectures

There are two types of chromatin, euchromatin and heterochromatin, that vary with the stages of the cell cycle. In particular, euchromatin with rich active genes localizes to the interior of the nucleus during interphase; heterochromatin usually localizes to the periphery of the nucleus.

20 Oct 2015

Penn researchers lay groundwork for developing lncRNA-based tools for new cancer treatment

Growing insights about a significant, yet poorly understood, part of the genome - the "dark matter of DNA" -- have fundamentally changed the way scientists approach the study of diseases.

13 Oct 2015

NS1 protein can be considered as vital target for development of new drugs to treat dengue: Study

Dengue is a mosquito-borne tropical disease currently endemic in more than 10 countries. According to the World Health Organization, 390 million people are infected by dengue every year.

7 Oct 2015

Unlocking the genes behind antibiotic resistance: an interview with Professor Romesberg

Bacteria are very, very diverse. This is why their susceptibility to different antibiotics can be very different. It also makes the tools they have to evolve resistance in many cases different.

30 Sep 2015

Leading cancer researchers address eight 'big questions'

Leading cancer researchers address eight of the "big questions" facing the field as part of the inaugural issue of Trends in Cancer, published by Cell Press.

30 Sep 2015

Researchers identify triple mechanism that prevents onset of chromosomal instability

Universitat Autònoma de Barcelona researchers have identified for the first time the triple mechanism that stops chromosome separation in response to situations that compromise the integrity of the genetic information. The loss of this response capacity is characteristic of cancerous cells.

18 Sep 2015

Myriad Genetics presents two posters on myPlan Lung Cancer prognostic test at WCLC 2015

Myriad Genetics, Inc. today presented two posters on its myPlan Lung Cancer prognostic test at the International Association for the Study of Lung Cancer 16th World Conference on Lung Cancer being held in Denver, Colo.

9 Sep 2015

Studies using yeast genetics provide new insights into cell-division cycle

Studies using yeast genetics have provided new, fundamental insights into the cell-division cycle, researchers at the University of Michigan Life Sciences Institute report.

2 Sep 2015

Researchers establish structure of important tumor-suppressing protein

An international group of researchers led by Carnegie Mellon University physicists Mathias Lösche and Frank Heinrich have established the structure of an important tumor suppressing protein, PTEN. Their findings provide new insights into how the protein regulates cell growth and how mutations in the gene that encodes the protein can lead to cancer.

21 Aug 2015

FAU researchers identify endogenous process that controls reproduction of cardiac muscle cells

Heart failure is the most common cause of death worldwide. The main reason for this is that damage to the human heart causes cardiac muscle cells to die, which in turn leads to reduced heart function and death. However, this is not the case for zebrafish or amphibians. If their hearts become damaged and cardiac muscle cells die, their remaining cardiac muscle cells can reproduce, allowing the heart to regenerate.

7 Aug 2015

MD Anderson scientists reveal role of metabolic enzyme fumarase in DNA repair

DNA double-strand breaks (DSBs) are the worst possible form of genetic malfunction that can cause cancer and resistance to therapy. New information published this week reveals more about why this occurs and how these breaks can be repaired.

4 Aug 2015

Gene responsible for cancer growth plays unexpected role in prostate cancer

A gene that is responsible for cancer growth plays a totally unexpected role in prostate cancer. The gene Stat3 is controlled by the immune modulator interleukin 6 and normally supports the growth of cancer cells. The international research team led by Prof. Lukas Kenner from the Medical University of Vienna, the Veterinary University of Vienna, and the Ludwig Boltzmann Institiute for Cancer Research (LBI-CR) discovered a missing link for an essential role of Stat3 and IL-6 signalling in prostate cancer progression.

22 Jul 2015

Study shows that 14-3-3 sigma opposes, reverses tumor-promoting metabolic programs

Every parent knows the maxim "feed a cold, starve a fever." In cancer, however, exactly how to feed or starve a tumor has not been easy to determine.

16 Jul 2015

Acceleration of cell cycle transition kinetic can make human blood stem cells more powerful

For the first time, the research group of Prof. Claudia Waskow at the Carl Gustav Carus Faculty of Medicine at Dresden Technical University is now describing a new mechanism in which the length of the G1 phase of the cell cycle has a dramatic impact on the fitness of human blood stem cells.

13 Jul 2015

Chromosomal abnormalities in embryos created for IVF can be predicted at earliest stage of human development

Scientists at Oregon Health & Science University, Stanford University, University of Valencia and IGENOMIX have discovered that chromosomal abnormalities in human embryos created for in vitro fertilization, or IVF, can be predicted within the first 30 hours of development at the cell-1 stage which results from the union of a female egg and male sperm.

8 Jul 2015

Review article provides in depth survey of studies focusing on retinoblastoma protein's role in apoptosis

Retinoblastoma protein RB1, which is named after a form of pediatric tumor of the eye, is among the most common genetically regulated cellular proteins to malfunction in human cancer. RB1 was also the first tumor suppressor gene to be identified and its modes of inactivation in retinoblastoma tumors provided the basis for the ground-breaking two-hit hypothesis by the geneticist Alfred G. Knudson in the 70s, according to which cancer is due to the accumulation of multiple 'hits' or mutations in certain genes.

3 Jul 2015