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Researchers use CRISPR-edited T cells to treat seriously ill children with resistant leukaemia

Researchers at Great Ormond Street Hospital for Children (GOSH) and UCL Great Ormond Street Institute of Child Health (UCL GOS ICH) have used CRISPR/Cas9 technology to engineer donor T cells to try to treat seriously ill children with resistant leukaemia, who had otherwise exhausted all available therapies.

27 Oct 2022

Study shows the potential of experimental monoclonal antibodies to treat Epstein-Barr virus infection

A panel of investigational monoclonal antibodies (mAbs) targeting different sites of the Epstein-Barr virus (EBV) blocked infection when tested in human cells in a laboratory setting.

27 Oct 2022

Pioneering gene editing technique can repair faulty T cells in patients with CTLA-4 insufficiency

A fault in cells that form a key part of the immune system can be repaired with a pioneering gene editing technique, finds new research demonstrated in human cells and mice, led by UCL scientists.

27 Oct 2022

Harmless group of bacteria linked with increased risk of death in patients with end-stage renal disease

A big group of bacteria found in our soil, our water and our showerheads are harmless for most of us, but a new study indicates they are associated with an increased risk of dying in individuals whose kidneys have failed.

25 Oct 2022

Researchers streamline way to manufacture CAR T-cells in just 24 hours

Researchers at University Hospitals (UH) Seidman Cancer Center and a biotech start-up company have developed a streamlined way to manufacture CAR T-cells for immunotherapy treatment in just 24 hours – an improvement over the team's previous benchmark of eight days and commercial suppliers that typically take three weeks.

25 Oct 2022

Collaborative research paves a new way to better health for patients with enlarged hearts

A University of Texas at Arlington multidisciplinary team will use a National Institutes of Health (NIH) grant to research new ways to improve the safety and effectiveness of medical procedures on patients with inoperable enlarged hearts.

24 Oct 2022

Effectiveness of COVID-19 vaccines in preventing hospitalizations among immunocompromised adults

Researchers investigated the efficacy of monovalent mRNA COVID-19 vaccines in immunocompromised adults during the Omicron dominance period starting December 2021.

24 Oct 2022

Competition may play important role in brain evolution, killifish study shows

In response to a high-competition environment, Trinidadian killifish evolve larger brains, increasing their fitness and survival rates, according to a new study in Ecology Letters by biologists at The University of Texas at Arlington.

20 Oct 2022

Study reveals racial disparities in access to advanced therapies for heart failure

Black adults treated at advanced heart failure centers received potentially life-changing therapies, such as transplants and heart pumps, about half as often as white adults, possibly due to racial bias, a small National Institutes of Health-supported study has found.

19 Oct 2022

IU researchers suggest the potential for a new approach to determining heart transplant candidacy

Researchers from Indiana University School of Medicine have concluded the medical and scientific establishment should expand and re-contextualize its understanding of cannabis use and heart transplantation, suggesting the potential for a completely new approach to determining transplant candidacy.

18 Oct 2022

People with end-stage renal disease and psoriasis do not have increased risk for heart attack

Studies have suggested that psoriasis is an independent risk factor for heart attack in the general population, but investigators have made the surprising finding that in people who also have end-stage renal disease, which shares many risk factors with heart disease, it is not.

18 Oct 2022

After Congress fails to add dental coverage, Medicare weighs limited benefit expansion

Proposed changes in Medicare rules could soon pave the way for a significant expansion in Medicare-covered dental services, while falling short of the comprehensive benefits that many Democratic lawmakers have advocated.

17 Oct 2022

Livers have a cumulative age of at least 100 years, researchers find

There is a small, but growing, subset of livers that have been transplanted and have a cumulative age of more than 100 years, according to researchers from University of Texas (UT) Southwestern Medical Center, Dallas, and TransMedics, Andover, Massachusetts.

17 Oct 2022

Certain hospital room features may influence patient outcomes after high-risk operations

Certain hospital room features, such as having a window view and distance from a nursing station, may influence clinical outcomes after undergoing high-risk operations, according to research findings presented at the Scientific Forum of the American College of Surgeons (ACS) Clinical Congress 2022

17 Oct 2022

Favorable survival outcomes among COVID-19 lung transplant recipients

The survival rate of lung transplant recipients with COVID-19 respiratory failure was not significantly different than other patients.

16 Oct 2022

Multi-center analysis shines light on invasive lobular carcinoma

A multi-center analysis of patients with invasive lobular carcinoma, or ILC -; the second most common histological subtype of invasive breast cancer in the U.S. -; showed that, despite its prevalence, ILC is detected later and has worse outcomes than the predominant subtype of invasive breast cancer, known as invasive ductal carcinoma (IDC), or no special type.

14 Oct 2022

Changes in the skin microbiome may contribute to development of GVHD after stem cell transplant

Organ damage occurs in up to 70 percent of patients in the first few months following stem cell transplant. The precise reasons for this potentially life-threatening reaction have long been the subject of scientific research.

13 Oct 2022

Clinical trial to test the safety, efficacy of bacteriophages for treating P. aeruginosa infections in CF patients

Cystic fibrosis (CF) is an inherited disorder that causes severe damage to the lungs and other organs in the body.

11 Oct 2022

Common diabetes medication identified as a possible treatment for atrial fibrillation

Cleveland Clinic researchers have identified a common diabetes medication, metformin, as a possible treatment for atrial fibrillation.

11 Oct 2022

Duke receives federal funding for HIV vaccine research

The Duke Human Vaccine Institute and the Department of Surgery at Duke University School of Medicine received a grant from the National Institute of Allergy and Infectious Diseases for HIV vaccine research that could total $25.9 million with full funding over five years.

11 Oct 2022

Transplant News and Research

Researchers use CRISPR-edited T cells to treat seriously ill children with resistant leukaemia

Study shows the potential of experimental monoclonal antibodies to treat Epstein-Barr virus infection

Pioneering gene editing technique can repair faulty T cells in patients with CTLA-4 insufficiency

Harmless group of bacteria linked with increased risk of death in patients with end-stage renal disease

Researchers streamline way to manufacture CAR T-cells in just 24 hours

Collaborative research paves a new way to better health for patients with enlarged hearts

Effectiveness of COVID-19 vaccines in preventing hospitalizations among immunocompromised adults

Competition may play important role in brain evolution, killifish study shows

Study reveals racial disparities in access to advanced therapies for heart failure

IU researchers suggest the potential for a new approach to determining heart transplant candidacy

People with end-stage renal disease and psoriasis do not have increased risk for heart attack

After Congress fails to add dental coverage, Medicare weighs limited benefit expansion

Livers have a cumulative age of at least 100 years, researchers find

Certain hospital room features may influence patient outcomes after high-risk operations

Favorable survival outcomes among COVID-19 lung transplant recipients

Multi-center analysis shines light on invasive lobular carcinoma

Changes in the skin microbiome may contribute to development of GVHD after stem cell transplant

Clinical trial to test the safety, efficacy of bacteriophages for treating P. aeruginosa infections in CF patients

Common diabetes medication identified as a possible treatment for atrial fibrillation

Duke receives federal funding for HIV vaccine research

Decoding Cannabis: Differentiating Hemp and Marijuana

Deciphering the Microbiome with The Microsetta Initiative

Leveraging the power of automation to boost research

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