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Experimental MERS-CoV vaccine shows promise in monkeys and camels

National Institutes of Health scientists and colleagues report that an experimental vaccine given six weeks before exposure to Middle East respiratory syndrome coronavirus (MERS-CoV) fully protects rhesus macaques from disease. The vaccine also generated potentially protective MERS-CoV antibodies in blood drawn from vaccinated camels.

20 Aug 2015

New supercomputer models can capture the behavior of human heart valves

New supercomputer models have come closer than ever to capturing the behavior of normal human heart valves and their replacements, according to recent studies by groups including scientists at the Institute for Computational Engineering and Sciences at The University of Texas at Austin and the Department of Mechanical Engineering at Iowa State University.

20 Aug 2015

EnGeneIC begins Phase 1 Tailored-EDV trial for advanced solid tumor

EnGeneIC Ltd., an emerging biopharmaceutical company focused on developing its proprietary EDV™ nanocell platform for the targeted delivery of cancer therapeutics, today announced that the first patient has been dosed in its Phase 1 Tailored-EDV trial. The trial is being conducted at the Northern Cancer Institute in Sydney, Australia.

19 Aug 2015

UC Davis researchers set out to identify biomarkers for early diagnosis of lung cancer

Despite decades of warnings about smoking, lung cancer is still the second-most common cancer and the leading cause of death from cancer in the U.S. Patients are often diagnosed only when their disease is already at an advanced stage and hard to treat. Researchers at the West Coast Metabolomics Center at UC Davis are trying to change that, by identifying biomarkers that could be the basis of early tests for lung cancer.

19 Aug 2015

Only 1 in 10 heart failure patients referred to cardiac rehabilitation program after hospitalization

Only 1 in 10 heart failure patients is referred to a cardiac rehabilitation program after being hospitalized, despite strong evidence that such exercise programs improve quality of life and reduce the likelihood of future hospitalizations.

19 Aug 2015

E-cigarettes becoming more widely available in developing countries

Most of the debate around e-cigarettes has focused on the developed world, but the devices are becoming more widely available in some low- and middle-income countries, where there is even greater potential for impact on public health, say two Stanford University School of Medicine researchers.

19 Aug 2015

U-M microbiome research may lead to new ways to prevent, fight lung infections in patients

With every breath you take, microbes have a chance of making it into your lungs. But what happens when they get there? And why do dangerous lung infections like pneumonia happen in some people, but not others? Researchers at the University of Michigan Medical School have started to answer these questions by studying the microbiome of the lungs - the community of microscopic organisms that are in constant contact with our respiratory system.

18 Aug 2015

Muscle mass appears to ward off bad cardiovascular effects of obesity

Even without losing fat, more muscle appears to go a long way in fighting off the bad cardiovascular effects of obesity. That emerging evidence has scientists looking hard for new targets to uncouple the unhealthy relationship between fat and cardiovascular disease.

18 Aug 2015

New OTEMTO phase three results show potential improvement to quality of life for COPD patients

Boehringer Ingelheim announced the publication of new data from the Phase IIIb OTEMTO® 1&2 trials (NCT01964352/NCT02006732), which show Spiolto® Respimat® (tiotropium/olodaterol) provides consistent, clinically meaningful improvements in quality of life versus placebo in patients with COPD

17 Aug 2015

DelMar obtains additional funding to support ongoing research project with lead product candidate VAL-083

DelMar Pharmaceuticals, Inc., a biopharmaceutical company focused on developing and commercializing proven cancer therapies in new orphan drug indications, today announced an increase in funding of up to CDN$287,000 from the National Research Council of Canada Industrial Research Assistance Program (NRC-IRAP) to support an ongoing research project.

17 Aug 2015

Researchers reveal how migrating tumour cells produce protein that helps set up home in bones

Cancer cells that migrate to the bone acquire a unique trait: They start to express the protein cathepsin K. Researchers from the University of Freiburg and the BIOSS Centre for Biological Signalling Studies have now solved why it is important for the migrating cells to produce this protein.

17 Aug 2015

Two new studies on eosinophilic granulomatosis with polyangiitis selected by Vasculitis Foundation

The Vasculitis Foundation is pleased to announce it has selected two new research studies on eosinophilic granulomatosis with polyangiitis (EGPA) /Churg Strauss for funding in the amount of $98,000.

14 Aug 2015

Arterial shunt in hybrid palliation better for hypoplastic left heart syndrome treatment

Children born with the major congenital heart defect hypoplastic left heart syndrome (HLHS) often must undergo a series of corrective surgeries beginning at birth. While most have the standard three-stage Norwood procedure, a hybrid strategy has been introduced to offset some disadvantages associated with the Norwood surgeries. In a report in The Journal of Thoracic and Cardiovascular Surgery, investigators compare whether outcomes can be improved if an arterial shunt is used as a source of pulmonary blood flow rather than the more conventional venous shunt as part of the hybrid strategy of HLHS surgical reconstruction.

14 Aug 2015

Researchers develop new way to personalize treatments for aggressive bladder cancer

Researchers at UC Davis, in collaboration with colleagues at Jackson Laboratory, have developed a new way to personalize treatments for aggressive bladder cancer.

14 Aug 2015

Researchers identify potential drug target to fight TB

The U.S. Food and Drug Administration recently approved the first new drug to fight tuberculosis (TB) in more than 40 years, but treatment still takes six months, 200 pills and leaves 40 percent of patients uncured. Thus, new targets are needed. Today in ACS Central Science, researchers report they have identified one such target -- a gene that allows the disease to camp out in human immune cells, and is thus essential for the organism's proliferation.

13 Aug 2015

New MRI contrast agent detects tiny breast cancer tumors, micrometastases

Researchers at Case Western Reserve University have developed a magnetic resonance imaging (MRI) contrast agent that detects much smaller aggressive breast cancer tumors and micrometastases than current agents can identify.

13 Aug 2015

Tumor cells associated with pancreatic cancer work with each other to increase tumor spread

Tumor cells associated with pancreatic cancer often behave like communities by working with each other to increase tumor spread and growth to different organs. Groups of these cancer cells are better than single cancer cells in driving tumor spread, according to new research from the Perelman School of Medicine at the University of Pennsylvania published in Cancer Discovery online in advance of the print issue.

13 Aug 2015

IASLC announces winners of Advocacy Travel Awards

The International Association for the Study of Lung Cancer announced today the recipients of the Advocacy Travel Awards. Five winners will receive funding to attend the 16th World Conference on Lung Cancer (WCLC) Sept. 6-9, 2015 at the Colorado Convention Center in Denver.

13 Aug 2015

Johns Hopkins study finds substantial increase in rate, costs of hospitalizations for pediatric pulmonary hypertension

A review of 15 years’ worth of data in a national pediatric medical database has documented a substantial increase in the rate of hospitalizations for children with a form of high blood pressure once most common in those with congenital heart disease.

13 Aug 2015

New approach may offer improved way to detect early breast cancer

Researchers have shown that magnetic resonance imaging (MRI) can detect the earliest signs of breast cancer recurrence and fast-growing tumors. Their approach detects micromestastases, breakaway tumor cells with the potential to develop into dangerous secondary breast cancer tumors elsewhere in the body.

12 Aug 2015

Lungs News and Research

Experimental MERS-CoV vaccine shows promise in monkeys and camels

New supercomputer models can capture the behavior of human heart valves

EnGeneIC begins Phase 1 Tailored-EDV trial for advanced solid tumor

UC Davis researchers set out to identify biomarkers for early diagnosis of lung cancer

Only 1 in 10 heart failure patients referred to cardiac rehabilitation program after hospitalization

E-cigarettes becoming more widely available in developing countries

U-M microbiome research may lead to new ways to prevent, fight lung infections in patients

Muscle mass appears to ward off bad cardiovascular effects of obesity

New OTEMTO phase three results show potential improvement to quality of life for COPD patients

DelMar obtains additional funding to support ongoing research project with lead product candidate VAL-083

Researchers reveal how migrating tumour cells produce protein that helps set up home in bones

Two new studies on eosinophilic granulomatosis with polyangiitis selected by Vasculitis Foundation

Arterial shunt in hybrid palliation better for hypoplastic left heart syndrome treatment

Researchers develop new way to personalize treatments for aggressive bladder cancer

Researchers identify potential drug target to fight TB

New MRI contrast agent detects tiny breast cancer tumors, micrometastases

Tumor cells associated with pancreatic cancer work with each other to increase tumor spread

IASLC announces winners of Advocacy Travel Awards

Johns Hopkins study finds substantial increase in rate, costs of hospitalizations for pediatric pulmonary hypertension

New approach may offer improved way to detect early breast cancer

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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