Metabolite News and Research

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Metabolites are the intermediates and products of metabolism. The term ''metabolite'' is usually restricted to small molecules.

The language of metabolites can be decoded with new genome technology

A team of microbiologists and genomicists has invented a genetic engineering tool that advances the study of secondary metabolites, which will expand our understanding of how microbes evolve.

14 Oct 2019

Researchers identify new targets to treat fibrotic diseases

When it comes to repairing injured tissue, specialized cells in the body known as fibroblasts are called into action. Fibroblasts give rise to healing cells called myofibroblasts, which generally is good in the short term - but bad when myofibroblast activation gets out of hand.

4 Oct 2019

Gut microbiome changes with cooking of plant foods, says new study

UC San Francisco and Harvard have found that profound changes occur in the human gut microbiome depending on whether plant food is consumed raw or cooked.

1 Oct 2019

Metabolite may predict cancer versus autism risk in PTEN patients

In a new study published in American Journal of Human Genetics, a team of researchers led by Charis Eng, M.D., Ph.D., Chair of Cleveland Clinic's Genomic Medicine Institute, identified a metabolite that may predict whether individuals with PTEN mutations will develop cancer or autism spectrum disorder.

26 Sep 2019

Metabolic imbalance in cancer patients associated with resistance to immune checkpoint blocker

A metabolic imbalance in some cancer patients following treatment with a checkpoint inhibitor drug, nivolumab, is associated with resistance to the immunotherapy agent and shorter survival, report scientists from Dana-Farber Cancer Institute, in collaborative work with the Broad Institute of MIT and Harvard.

25 Sep 2019

Paracetamol poisoning soars over the past decade in Australia

Paracetamol is one of the most common painkillers and antipyretics used in Australia. However, a new study hopes for the restriction in the access to the drug, due to a serious spike in paracetamol poisonings.

2 Sep 2019

Diet can alter efficacy of type-2 diabetes drug via its action on gut bacteria, study shows

Research published in Cell on 29th August by the groups of Filipe Cabreiro from the MRC London Institute of Medical Sciences and Imperial College and Christoph Kaleta from Kiel University in Germany has demonstrated that diet can alter the effectiveness of a type-2 diabetes drug via its action on gut bacteria.

30 Aug 2019

A single cholesterol-derived molecule promotes adiposity

A single cholesterol-derived molecule, called 27-hydroxycholesterol (27HC), lurks inside your bloodstream and will increase your body fat, even if you don't eat a diet filled with red meat and fried food. That kind of diet, however, will increase the levels of 27HC and body weight.

29 Aug 2019

Ketogenic diet shown to support intestinal stem cells

Scientists have discovered that ketone bodies produced during the ketogenic diet trigger the proliferation of intestinal stem cells in adults.

26 Aug 2019

Scientists identify unique way to treat incurable type of children's brain cancer

An international team of researchers led by Yale University, University of Iowa, and the Translational Genomics Research Institute, an affiliate of City of Hope, has discovered a new pathway that may improve success against an incurable type of children's brain cancer.

23 Aug 2019

Researchers seek to identify biomarkers that may predict suicide risk among women

A four-year, $3.1 million grant from the National Institute of Mental Health will help researchers determine how the stabilization of ovarian hormones estradiol and progesterone may help lower symptoms associated with suicidality among females with longstanding thoughts of suicide.

5 Aug 2019

Highly sensitive 'sniff-cam' to detect disease biomarkers

Having bad breath can mean someone ate a smelly lunch, but it could indicate that the person is sick. Various scent compounds have been linked to illnesses such as diabetes, lung cancer and Parkinson's disease, leading scientists to develop technology that measures these substances.

31 Jul 2019

Scientists investigate how fungus interacts with bacteria to trigger Crohn's disease

Scientists have known that bacteria in the gut, along with environmental and genetic factors, contribute to the debilitating intestinal ailment of Crohn's disease.

26 Jul 2019

Tailored adherence strategies needed to engage young African women in consistent PrEP use

In a study of open-label Truvada as daily pre-exposure prophylaxis (PrEP) to prevent HIV among 427 young African women and adolescent girls, 95% initiated the HIV prevention strategy, and most used PrEP for the first three months.

24 Jul 2019

Molecular action that enables cilantro to effectively delay certain seizures uncovered

Herbs, including cilantro, have a long history of use as folk medicine anticonvulsants. Until now, many of the underlying mechanisms of how the herbs worked remained unknown.

23 Jul 2019

Study examines role of plastic exposure in irregular heart rhythms, arrhythmias

Calling an ambulance during an emergency, emailing a breaking news or journal article before a 5 p.m. deadline and maintaining conditions during the fifth week of a 6-week lab study, without altering the light or temperature, requires electricity and translates into time, money and lives

22 Jul 2019

Key metabolic changes found in patients with chemotherapy-related heart toxicity

More and more patients are being treated successfully for cancer. However, some cancer treatments that are very effective for breast cancer – medications like anthracyclines and trastuzumab – can cause heart dysfunction and lead to heart failure.

19 Jul 2019

Liver fat biomarker levels linked with metabolic health benefits of exercise, study finds

While genetics and other factors like age and sex contribute to each individual's response to exercise, little is known about the biological mechanisms by which physical activity brings about beneficial changes to the body.

11 Jul 2019

Study reports role of cancer gene in tumor microenvironment

The tumor microenvironment is a mix of fluids, immune cells and blood vessels which envelops the tumors. Interactions between tumor cells and the TME determine the progression and fate of tumors.

4 Jul 2019

Hesperos' multi-organ model correctly determine cardiotoxic mechanisms

Hesperos Inc., pioneers of the "human-on-a-chip" in vitro system has announced the use of its innovative multi-organ model to successfully measure the concentration and metabolism of two known cardiotoxic small molecules over time, to accurately describe the drug behavior and toxic effects in vivo.