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Northwestern Medicine scientists discover new therapeutic target for Parkinson’s disease

Northwestern Medicine scientists have uncovered a new mechanism by which mutations in a gene parkin contribute to familial forms of Parkinson's disease.

19 Jul 2023

Epigenetic formatting of satiety gene may increase risk of obesity in women

What determines whether we become overweight? Aside from lifestyle, predisposition plays a role, but genes cannot fully explain the inherited propensity to accumulate excess weight.

19 Jul 2023

Targeting the "don't eat me" signal may improve immunotherapy for glioblastoma

"Don't eat me!" That's how one might translate the signal that the cancer cells in a glioblastoma send to the macrophages (white blood cells specialized in removing dead and dying cellular matter) in the brain.

19 Jul 2023

Study shows how NSAIDs exacerbate C. difficile infections

Why do nonsteroidal anti-inflammatory drugs (NSAIDs) exacerbate gastrointestinal infections by Clostridioides difficile, the leading cause of antibiotic-associated diarrhea worldwide?

19 Jul 2023

New method could make post-stroke motor rehabilitation more effective and affordable

The longest nerve in the human body starts in the brain and meanders its way down the neck and into the chest, where it splits into separate branches, winding its twisting tendrils to touch each internal organ.

19 Jul 2023

Sex-based differences in Lyme disease symptoms and outcomes

Women with Lyme disease take longer to get diagnosed, have more severe symptoms and experience higher rates of disability when compared to men.

19 Jul 2023

New emergency department for over 80s reduces wait times

The formation of the country's first emergency department for the over 80s led to a significant decrease in time spent in A&E - according to research from the Norfolk and Norwich University Hospital (NNUH) and University of East Anglia (UEA).

19 Jul 2023

New kidney tissue atlas could advance understanding of kidney injury and disease

Researchers at Washington University School of Medicine in St. Louis helped lead a major study, funded by the National Institutes of Health (NIH), that uncovered rich cellular and molecular diversity in healthy and diseased kidneys, creating a kidney tissue atlas that will help further understanding of kidney injury and disease.

19 Jul 2023

Researchers achieve first-ever gram-scale synthesis of tanzawaic acid B

The discovery of antibiotics in 1928 was a major turning point in the history of medicine. For the first time since the dawn of human civilization, doctors had gained access to an extremely powerful and effective tool to fight against a wide variety of bacterial infections.

19 Jul 2023

Cardiac rehabilitation linked to decreased risk of death after surgery

For millions of Americans who have heart surgery or experience cardiovascular complications, like heart attack or heart failure, they may be encouraged to participate in cardiac rehabilitation.

19 Jul 2023

Older adults see the benefit in cognitive screening, but many have not been tested

Eighty percent of older adults see the benefit of tests that can give an early warning that a person's memory and thinking abilities have started to decline, a new poll of people age 65 to 80 finds.

19 Jul 2023

Research opens new possibilities for treating inflammatory diseases

The inflammatory response is indispensable for protective immunity, yet microbial pathogens often trigger an excessive response, 'cytokine storm', harmful to the host.

19 Jul 2023

The painful legacy of ‘law and order’ treatment of addiction in jail

Megan Dunn, who has struggled with addiction since her teens, points to the moment her life went "deeply downhill."

19 Jul 2023

How diet, exercise can improve mental and physical functioning in older cancer survivors

Researchers from Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine and Dana Farber Cancer Institute in Boston have been awarded $7 million in total funding to study how diet and exercise impact mental and physical functioning in older cancer survivors and their caregivers.

18 Jul 2023

Opioid addiction linked to neural differences in response to drug cues

An Icahn School of Medicine at Mount Sinai study sheds new light on some of the underlying neurobiological mechanisms of opioid addiction, which accounted for three-quarters of the more than 100,000 fatal drug overdoses in the United States in 2021.

18 Jul 2023

Study reveals molecular mechanisms of H. pylori-induced gastric carcinogenesis

Helicobacter pylori (H. pylori) infections are commonly associated with abdominal pain, bloating, and acidity. Clinical evidence suggests that infection with H. pylori cagA+ strains dramatically increases the risk of developing gastric cancer.

18 Jul 2023

EAE Hub model reduces barriers to early autism diagnosis

A new study led by Indiana University School of Medicine researchers shows primary care clinicians who receive specialized training can make accurate autism diagnoses for over 80 percent of young children referred with developmental delays, providing compelling evidence that community-based models of autism evaluation are a potential solution for improving access to this needed service.

18 Jul 2023

Hearing aids may offer protection against cognitive decline in older adults at high risk of dementia

While hearing aids and audiological support services did not have any impact on cognitive decline over 3 years in a general population of older adults, treating hearing loss protected against cognitive decline in older adults at greater risk of dementia.

18 Jul 2023

MCW professor awarded $13 million NIH grant to study misplaced calcification in AMD and Alzheimer's

Francesca Marassi, PhD, professor and chair of biophysics at the Medical College of Wisconsin (MCW), has been awarded a five-year, $13 million program project grant (PPG) by the National Institutes of Health (NIH) to study misplaced calcification in the eyes and brains of patients suffering from age-related macular degeneration (AMD) and Alzheimer's disease (AD).

18 Jul 2023

Study finds link between DHX9 gene mutations and neurodevelopmental disorders

A group of 20 patients with undiagnosed neurodevelopmental disorders ranging from severe to mild has now received a genetic diagnosis thanks to an international team of researchers at the GREGoR Research Center at Baylor College of Medicine, the Chinese University of Hong Kong, the German Mouse Clinic and collaborating institutions.

18 Jul 2023