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Chemotherapy regimen predicts steatohepatitis and an increase in 90-day mortality after surgery for hepatic colorectal metastases

Patients and their physicians should be careful when selecting a chemotherapy drug to treat colorectal cancer that has spread to the liver, say researchers at The University of Texas M. D. Anderson Cancer Center in Houston.

3 May 2006

Simple formula that will enable anesthesiologists to predict blood needs in heart surgery

Duke University Medical Center researchers have developed a simple formula that will enable anesthesiologists to predict, based on individual patient characteristics, how much blood to have on hand in the operating room prior to coronary artery bypass surgery.

3 May 2006

Protein produced by immune cells during malaria infection triggers severe anemia

Richard Bucala and colleagues at Yale University show that immune cells in mice with malaria secrete a protein called MIF, which decreases the production of red blood cells (RBCs) from the bone marrow. The study appears in The Journal of Experimental Medicine.

3 May 2006

Epstein-Barr virus may trigger multiple sclerosis

Researchers have found that patients with multiple sclerosis (MS) carry a population of immune cells that overreact to Epstein-Barr virus.

3 May 2006

Dimensional analysis of the concept of obesity

Health professionals need to use more than tape measures and scales to define and tackle obesity, according to a paper in the latest Journal of Advanced Nursing.

3 May 2006

Short-course postexposure antibiotic prophylaxis combined with vaccination protects against experimental inhalational anthrax

Anthrax vaccine administered in combination with a short course of antibiotics completely protected nonhuman primates from inhalational anthrax, the most lethal form of the disease, according to scientists at the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID).

3 May 2006

The 30-year natural history of type 1 diabetes complications

...while cases of premature death and a few other complications have declined, rates of other serious diabetes-related disorders such as heart and eye disease have not improved over the past 25 to 30 years.

3 May 2006

Early myocardial enhancement defects (dark spots) on multidetector CT are valuable predictors of myocardial viability

...in patients who have suffered a heart attack, reported doctors from the departments of cardiology and radiology at Rambam Medical Center in Haifa, Israel.

3 May 2006

British healthier than Americans in middle-age

According to a large international study middle-aged Americans are not as healthy as their British cousins.

2 May 2006

Ability to complete quarter-mile walk a powerful predictor of health outcomes in elderly

Walking fitness makes a significant difference in predicting the likelihood of future disability in the elderly, according to a study published today in the Journal of the American Medical Association.

2 May 2006

Genetic and environmental factors impact chronic fatigue syndrome patients

People who suffer from chronic fatigue syndrome (CFS) have a genetic make up that affects the body's ability to adapt to change, according to a series of papers released last week by the Centers for Disease Control and Prevention (CDC).

2 May 2006

Blood clots in the brain linked to Alzheimer's and dementia

According to researchers, from the University of Manchester, UK, spontaneous blood clots are significantly associated with both Alzheimer's disease and vascular dementia.

From The University of Manchester 1 May 2006

Human brain observed to shut down 'self'

Everybody has experienced a sense of "losing oneself" in an activity--whether a movie, sport, sex, or meditation. Now, researchers have caught the brain in the act of losing "self" as it shuts down introspection during a demanding sensory task. New findings show that self-related function actually shuts down during such intense sensory tasks.

28 Apr 2006

HCM detection rates doubled when genetic testing and imaging information are combined

Currently that genetic test correctly detects HCM only 40 percent of the time. But coupled with imaging information, the detection power of the test nearly doubles, to 79 percent, says Steve Ommen, M.D., director of Mayo's HCM Clinic and co-lead investigator of the Mayo Clinic research team.

28 Apr 2006

Transplanted stem cells hoped to be able to regenerate damaged heart muscle in first heart attack victims

Rush cardiologists are hoping that transplanted stem cells can regenerate damaged heart muscle in those who experience a first heart attack. The study involves an intravenous infusion of adult mesenchymal stem cells from healthy donor bone marrow that might possibly reverse damage to heart tissue.

28 Apr 2006

Combinatorial approach found to reverse the onset of type 1 diabetes

A major finding, which represents an important step toward a potential cure for type 1 (insulin-dependent) diabetes, has been made by a research team at the La Jolla Institute for Allergy & Immunology (LIAI). The team, led by Matthias von Herrath, M.D., an internationally recognized expert on the molecular basis of type 1 diabetes, used a combinatorial treatment approach in laboratory mice and found it reversed recent onset type 1 diabetes in the majority of animals tested.

28 Apr 2006

Study indicates how drug efficacy can be increased by manipulating the signalling mechanism

Researchers believe they have found a way to change the action of 60 percent of currently available medications, in some cases making them many times more effective, according to an article published in the April 21 edition of the journal Science. The discovery has the potential to improve treatments for diseases including heart disease, cancer, diabetes, depression and arthritis. The study describes a new way to manipulate perhaps the most important signaling mechanism in human cells: G-protein coupled receptors (GPCRs).

28 Apr 2006

Finding indicate why some kinds of Leukemia are more aggressive than others

New clues to why some kinds of leukemia are more aggressive and deadly than others are coming from research examining the types of genetic damage that allow some blood cells to grow out of control, scientists report.

28 Apr 2006

Enhancing the function of the protein SOCS3 could be a more effective way to regulate cell responses

A discovery made at The Walter and Eliza Hall Institute provides new insights into enhancing the function of the protein SOCS3, which regulates the response of cells to external stimuli.

26 Apr 2006

Preconception health care should be part of routine medical visits

Every visit to the doctor for women of childbearing age should be considered an opportunity to discuss reproductive health- especially since more than half of all pregnancies are unintended, according to a report published today in the U.S. Centers for Disease Control and Prevention's journal Morbidity and Mortality Weekly Report Recommendations and Reports.

26 Apr 2006

Blood News and Research

Chemotherapy regimen predicts steatohepatitis and an increase in 90-day mortality after surgery for hepatic colorectal metastases

Simple formula that will enable anesthesiologists to predict blood needs in heart surgery

Protein produced by immune cells during malaria infection triggers severe anemia

Epstein-Barr virus may trigger multiple sclerosis

Dimensional analysis of the concept of obesity

Short-course postexposure antibiotic prophylaxis combined with vaccination protects against experimental inhalational anthrax

The 30-year natural history of type 1 diabetes complications

Early myocardial enhancement defects (dark spots) on multidetector CT are valuable predictors of myocardial viability

British healthier than Americans in middle-age

Ability to complete quarter-mile walk a powerful predictor of health outcomes in elderly

Genetic and environmental factors impact chronic fatigue syndrome patients

Blood clots in the brain linked to Alzheimer's and dementia

Human brain observed to shut down 'self'

HCM detection rates doubled when genetic testing and imaging information are combined

Transplanted stem cells hoped to be able to regenerate damaged heart muscle in first heart attack victims

Combinatorial approach found to reverse the onset of type 1 diabetes

Study indicates how drug efficacy can be increased by manipulating the signalling mechanism

Finding indicate why some kinds of Leukemia are more aggressive than others

Enhancing the function of the protein SOCS3 could be a more effective way to regulate cell responses

Preconception health care should be part of routine medical visits

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