Bioinformatics News and Research

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Bioinformatics is the application of information techniques for the storage, retrieval, and analysis of large quantities of biological data.

The potential of mRNA vaccines for a wide range of diseases

A new review article published in the journal Briefings in Functional Genomics focuses on the general characteristic features and mechanisms of mRNA vaccines. Further, this review has summarized the current progress of mRNA vaccines that have been developed for wide-ranging diseases, including COVID-19 disease.

8 Jun 2021

Measuring how patterns of gene expression change in children may help predict T1D progression

Type 1 diabetes (T1D) is an autoimmune disease in which a misdirected immune system gradually destroys healthy pancreatic islet β cells, resulting in a lack of insulin.

7 Jun 2021

Study shows how different microbiomes could be harnessed to boost human health

There's a lot of interest right now in how different microbiomes--like the one made up of all the bacteria in our guts--could be harnessed to boost human health and cure disease.

7 Jun 2021

Study aims to improve early screening for adverse childhood experiences by using precision medicine

Children's Hospital Los Angeles has been awarded a $2 million grant from the state of California to study a precision medicine approach to screening children for adverse childhood experiences.

3 Jun 2021

Epigenetic regulation affects the 3D structure of genome

All the cells of an organism share the same DNA sequence, but their functions, shapes or even lifespans vary greatly. This happens because each cell "reads" different chapters of the genome, thus producing alternative sets of proteins and embarking on different paths.

3 Jun 2021

Study provides new knowledge about molecular mechanisms underlying human traits, diseases

A new study analyzing the association between an individual's genetics (genotype) and their observable characteristics resulting from the interaction of genetics and the environment (phenotype), contributes new knowledge to the understanding of human complex traits and diseases.

1 Jun 2021

New method helps identify rare genetic disease that affects brain development

Rare disease experts detail the first results of an unprecedented collaboration to diagnose people living with unsolved cases of rare diseases across Europe.

1 Jun 2021

Could a mathematical application of information theory identify and predict SARS-CoV-2 mutations?

An interesting new study by researchers at the University of Portsmouth, UK, describes the use of a mathematical method to sequence genomes based on information theory. The method offers an alternative to clinical techniques, allowing mutations to be detected and possibly even predicted. In this way, it opens new research opportunities in bioinformatics and genetics.

31 May 2021

Inflammatory brain injury higher in men with acute COVID-19, finds study

The COVID-19 pandemic has been associated with both short- and long-term neurologic complications, including stroke, brain fog and persistent tiredness. A new study concludes that the effects of SARS-CoV-2 on the central nervous system (CNS) are due to the endothelial injury and inflammation that this produces in the brain.

31 May 2021

A novel multi-epitope COVID-19 vaccine developed using reverse vaccinology

A new study has been published in the Journal of Biomolecular Structure and Dynamics which focuses on the evaluation of E, M, N, ORF10, ORF8, ORF3a, and M proteins using bioinformatics tools to develop a multi-epitope COVID-19 vaccine. The researchers utilized in-silico methods to incite humoral and cellular immune responses.

31 May 2021

Scientists develop new resources to combat cancer, advance cutting-edge genomics research

University of Virginia School of Medicine scientists have developed important new resources that will aid the battle against cancer and advance cutting-edge genomics research.

27 May 2021

Researchers develop a method to detect SARS-CoV-2 and variants simultaneously

Researchers demonstrate a method of detecting the presence and mutations in the SARS-CoV-2 virus using the smaller and cheaper Oxford Nanopore sequencer, a method they believe could make pandemic surveillance faster and cheaper.

26 May 2021

Previous H3N2 influenza A infection may explain some cases of severe COVID-19

According to research from the University of California, some cases of severe coronavirus disease 2019 (COVID-19) may be related to the immunological memory of previous H3N2 influenza A infection.

26 May 2021

Targeting mTOR pathway can improve the effectiveness of chemotherapies for pediatric brain cancer

Two experimental drug approaches that target vulnerabilities in cancer cell metabolism may extend survival and enhance the effectiveness of standard chemotherapies for a highly aggressive type of pediatric brain cancer.

21 May 2021

AMP and APC urge congress to pass the VITAL Act

The Association for Molecular Pathology (AMP) and the Association of Pathology Chairs (APC) commend U.S. Senator Rand Paul (R-KY) for introducing legislation that would allow molecular pathology professionals to continue advancing and offering high-quality laboratory developed testing procedures (LDPs) for patient care.

19 May 2021

New coronavirus variants can be effectively eliminated by disinfection, thorough hand washing

The researchers found that the variants have a similar surface stability as the wild type virus under laboratory conditions, but can be effectively eliminated by disinfection and thorough hand washing, heat or alcohol treatment.

18 May 2021

New atlas can help understand the relationship between healthy and breast cancer cells

Australian researchers have documented the diversity of cells in the human breast, explaining the relationship between healthy breast cells and breast cancer cells.

17 May 2021

New method to efficiently deliver drugs into cells

A new, patented method called Progressive Mechanoporation makes it possible to mechanically disrupt the membranes of cells for a short time period and let drugs or genes inside cells.

12 May 2021

Study reveals genes that cause loss of lung function in active smokers

Chronic Obstructive Pulmonary Disease (COPD) is a disease caused by cigarette smoking that reduces lung function and causes difficulty breathing. It is the third leading cause of death worldwide. Current treatments for COPD only affect symptoms, not progression. Identifying who is going to get COPD before they get it is key to figuring out how to intercept the disease at an early stage.

12 May 2021

Evolutionary-spreading model predicts another devastating COVID-19 peak around July 2021

The emergence of this variant highlighted the uneven pace of mutation and selection of variants. New bioinformatics tools are the need of the hour to clarify this and confirm a dynamic evolution by tracking the mutation rates of the spike protein. It generally takes 1 – 6 months for current variants causing COVID-19 case peaks and deaths to survive the pressure of selection.

11 May 2021

Bioinformatics News and Research

Further Reading

The potential of mRNA vaccines for a wide range of diseases

Measuring how patterns of gene expression change in children may help predict T1D progression

Study shows how different microbiomes could be harnessed to boost human health

Study aims to improve early screening for adverse childhood experiences by using precision medicine

Epigenetic regulation affects the 3D structure of genome

Study provides new knowledge about molecular mechanisms underlying human traits, diseases

New method helps identify rare genetic disease that affects brain development

Could a mathematical application of information theory identify and predict SARS-CoV-2 mutations?

Inflammatory brain injury higher in men with acute COVID-19, finds study

A novel multi-epitope COVID-19 vaccine developed using reverse vaccinology

Scientists develop new resources to combat cancer, advance cutting-edge genomics research

Researchers develop a method to detect SARS-CoV-2 and variants simultaneously

Previous H3N2 influenza A infection may explain some cases of severe COVID-19

Targeting mTOR pathway can improve the effectiveness of chemotherapies for pediatric brain cancer

AMP and APC urge congress to pass the VITAL Act

New coronavirus variants can be effectively eliminated by disinfection, thorough hand washing

New atlas can help understand the relationship between healthy and breast cancer cells

New method to efficiently deliver drugs into cells

Study reveals genes that cause loss of lung function in active smokers

Evolutionary-spreading model predicts another devastating COVID-19 peak around July 2021

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