Liver Disease News and Research

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The liver is one of the largest solid organs of the body. It is located in the upper right part of the abdomen. Most of the organ lies under cover of the rib cage.

Children’s Hospital Colorado helps prove safety and efficacy of CF treatment in younger pediatric patients

Researchers at the Children's Hospital Colorado Breathing Institute, the largest pediatric cystic fibrosis (CF) clinical care center in the U.S., participated in the pivotal international multi-center Phase 3 clinical trial, sponsored by Vertex Pharmaceuticals Incorporated, leading to FDA approval of TRIKAFTA (elexacaftor/tezacaftor/ivacaftor), a highly effective CF treatment, for patients ages 6 through 11 who have at least one copy of the F508del mutation.

17 Aug 2021

Clinical discussions on diet-associated NAFLD and COVID-19 mortality risk among PPI users

The August issue of The American Journal of Gastroenterology includes clinical discussions of diet-associated NAFLD risk and increased risk of mortality from COVID-19 among PPI users.

16 Aug 2021

Study finds novel approach to attenuate mitochondrial dysfunction that drives diet-induced obesity

A team of University of California, Irvine, scientists have discovered a novel pharmacological approach to attenuate the mitochondrial dysfunction that drives diet-induced obesity.

12 Aug 2021

Study aims to ascertain body mass index cutoffs for type 2 diabetes in Xinjiang population

Oncotarget published "Appropriate body mass index cutoffs for type 2 diabetes in Xinjiang population: defining the influence of liver aminotransferase" which reported that these authors retrospective cohort study, T2DM was diagnosed when FBS ≥ 7.0 mmol/L, BMI of participants with baseline fasting < 7.0 mmol/L was divided by percentiles and by aminotransferanse .

9 Aug 2021

Research: Only 26% of areas in the UK have an effective pathway in place for early liver disease detection

New research published today in a peer review journal shows only 26% of areas in the UK have an effective pathway in place for the early detection of liver disease.

4 Aug 2021

Analysis: Keto diets place pregnant women and kidney disease patients at risk of adverse health effects

In the most comprehensive analysis yet of ketogenic (keto) diets, a review in Frontiers in Nutrition finds keto diets place pregnant women and kidney disease patients at risk of adverse health effects.

3 Aug 2021

Two new proteins identified as therapeutic targets for preventing NAFLD and associated liver cancer

An international study led by the Lipids&Liver research team at the UPV/EHU-University of the Basque Country, the results of which have recently been published in the prestigious journal Cancer Research, has demonstrated that inhibiting either of the proteins E2F1 or E2F2 in the liver protects against the development of obesity-driven nonalcoholic fatty liver disease and its progression to cancer.

29 Jul 2021

3D imaging reveals degeneration of liver sympathetic nerves in nonalcoholic fatty liver disease

With the application of a novel three-dimensional imaging technology, researchers at Karolinska Institutet in Sweden have discovered that one portion of the autonomic nervous system in the liver undergoes severe degeneration in non-alcoholic fatty liver disease.

22 Jul 2021

'Good cholesterol' protects the liver from inflammation and injury, study shows

The body's so-called good cholesterol may be even better than we realize. New research from Washington University School of Medicine in St. Louis suggests that one type of high-density lipoprotein (HDL) has a previously unknown role in protecting the liver from injury.

22 Jul 2021

Children of obese mothers at increased risk of fatty liver disease

Children and young people whose mothers had a BMI greater than 30 during early pregnancy are at an increased risk of fatty liver disease.

19 Jul 2021

Chemical modification in RNA molecules may offer protection against liver disease

A chemical modification that occurs in some RNA molecules as they carry genetic instructions from DNA to cells' protein-making machinery may offer protection against non-alcoholic fatty liver, a condition that results from a build-up of fat in the liver and can lead to advanced liver disease, according to a new study by UCLA researchers.

19 Jul 2021

New study finds an association between alcohol use and higher risk of several cancers

A new study from the World Health Organization's International Agency for Research on Cancer (IARC), published in the journal Lancet Oncology, has found an association between alcohol and a substantially higher risk of several forms of cancer, including breast, colon, and oral cancers.

14 Jul 2021

Study reveals how non-alcoholic fatty liver disease can develop into a life-threatening complication

Researchers revealed how non-alcoholic fatty liver disease can develop into a life-threatening complication.

13 Jul 2021

Patient characteristics including demographic factors and comorbidities can accurately predict the outcome of COVID-19 infection severity

New machine learning models incorporating COVID-19 infection data show that patient demography is a key predictor of infection outcome.

13 Jul 2021

Selective immunotoxins may help treat liver fibrosis

Chronic alcohol abuse and hepatitis can injure the liver and lead to fibrosis, the buildup of collagen and scar tissue. As a potential approach to treating liver fibrosis, University of California San Diego School of Medicine researchers and their collaborators are looking for ways to stop liver cells from producing collagen.

12 Jul 2021

New approach that uses machine learning could transform drug development

Writing in the July 12, 2021 online issue of Nature Communications, researchers at University of California San Diego School of Medicine describe a new approach that uses machine learning to hunt for disease targets and then predicts whether a drug is likely to receive FDA approval.

12 Jul 2021

Adults with ADHD at higher risk of many physical conditions, finds study

Adults with ADHD are at higher risk of a wide range of physical conditions, including nervous system, respiratory, musculoskeletal, and metabolic diseases, according to a large register-based study from Karolinska Institutet in Sweden published in The Lancet Psychiatry.

7 Jul 2021

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