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Gut microbiota holds clues to predicting Alzheimer's risk

Gut microbiome alterations in preclinical Alzheimer's disease (AD) were investigated, revealing distinct taxonomic composition and potential markers of AD risk. These findings contribute to understanding AD pathology and offer insights into gut-derived markers for AD.

15 Jun 2023

Destroying the tether of shattered chromosomal fragments may help prevent cancerous mutations

Healthy cells work hard to maintain the integrity of our DNA, but occasionally, a chromosome can get separated from the others and break apart during cell division.

15 Jun 2023

Innovative method to map specific DNA markings could be used for early cancer detection

Researchers from the Perelman School of Medicine at the University of Pennsylvania have invented a new way to map specific DNA markings called 5-methylcytosine (5mC) which regulate gene expression and have key roles in health and disease.

15 Jun 2023

Overly restricting opioid use during surgery may be doing more harm than good

Because of the opioid crisis, physicians are less likely to administer opioids to help manage patients' pain, even in the operating room.

15 Jun 2023

$1.9 million grant awarded to explore the effect of antifungal drugs in Crohn's patients

Dr. Iliyan D. Iliev, an associate professor of immunology in medicine in the Division of Gastroenterology and Hepatology, co-director of the Microbiome Core and a member of the Jill Roberts Institute for Research in Inflammatory Bowel Disease (IBD) at Weill Cornell Medicine, is the lead investigator on a grant to Weill Cornell Medicine from The Leona M. and Harry B. Helmsley Charitable Trust to target pathogenic fungi in patients with Crohn's disease.

15 Jun 2023

BMI not a complete measure of metabolic health, research shows

Body mass index (BMI) is not a complete measure of metabolic health, and a high proportion of U.S. adults with normal BMI still have obesity, according to research being presented Friday at ENDO 2023, the Endocrine Society's annual meeting in Chicago, Ill.

15 Jun 2023

Bempedoic acid may offer an alternative to the popular cholesterol-lowering drugs

A medication called bempedoic acid reduced the risk of cardiac events as well as statins and may offer an alternative to the popular cholesterol-reducing medications, according to industry-supported research being presented Thursday at ENDO 2023, the Endocrine Society's annual meeting, in Chicago, Ill.

15 Jun 2023

Sleep duration and quality may affect the risk for diabetes

Fewer than six hours or more than 10 hours of sleep, and poor quality of sleep are associated with a greater risk for diabetes, according to research being presented Thursday at ENDO 2023, the Endocrine Society's annual meeting in Chicago, Ill.

15 Jun 2023

Children with diabetes often fail to use CGM alarms to alert to dangerously low or high blood sugar levels

Children and teenagers who use continuous glucose monitors (CGM) to manage diabetes often fail to use the appropriate alarm settings to alert to dangerously low or harmful high blood sugar levels, according to a study being presented Thursday at ENDO 2023, the Endocrine Society's annual meeting in Chicago, Ill.

15 Jun 2023

Women living with PCOS experience greater body image concerns than normal people

Women living with polycystic ovary syndrome (PCOS) experience greater body image concerns than individuals without the condition, according to research being presented Saturday at ENDO 2023, the Endocrine Society's annual meeting in Chicago, Ill.

15 Jun 2023

Scientist identifies the specific mechanistic cause of life-threatening fungal infections

Major fungal infections have become more common across the globe, and one unexpected phenomenon among the rise of fungi is life-threatening infections as a result of a complication of certain immunotherapies and small molecule kinase inhibitors.

15 Jun 2023

New approach improves diagnosis of limb-girdle muscular dystrophy

It's not easy to distinguish between the dozens of subtypes of limb girdle muscular dystrophy -; a rare, genetic muscle disease characterized by weakness in the hips and shoulders that causes difficulty walking and lifting the arms.

15 Jun 2023

Promising emerging treatment for cardiac arrest patients yields similar results to targeted standard care

A promising emerging treatment (hypercapnia) for comatose adult cardiac arrest patients has been found to yield similar results to current treatment, in a new study published today in the prestigious medical journal New England Journal of Medicine.

15 Jun 2023

Experts develop latest consensus statement on concussion in sport for optimizing the care of athletes

A group of more than 100 expert researchers and clinicians from around the world has distilled and synthesized new scientific evidence and updated existing recommendations with the aim of optimizing the care of athletes at all levels of participation who have, or who are at risk of, concussion.

15 Jun 2023

COVID-19 susceptibility mechanism discovered using a newly created tool

Researchers have discovered a mechanism for COVID-19 susceptibility using a newly created tool. The tool, GASPACHO, captures dynamic changes in gene expression along the innate immune response, allowing researchers to identify genes and molecular pathways associated with disease risk that have previously been too complex to detect or interpret.

15 Jun 2023

Insilico announces new multimodal transformer-based aging clock for processing diverse data sets

Clinical stage generative artificial intelligence (AI)-driven drug discovery company Insilico Medicine ("Insilico") has announced a new multimodal transformer-based aging clock that is capable of processing diverse data sets and providing insights into biomarkers for aging, mapping them to genes relevant to both aging and disease, and discovering new therapeutic targets designed to slow or reverse both aging and aging-related diseases.

15 Jun 2023

UC researchers discover treatment for a rare cancer-like lung disease in women

A treatment for a rare cancer-like lung disease found in women of childbearing age may have been discovered by University of Cincinnati researchers.

15 Jun 2023

New findings expand the genotypic spectrum of NPRL3-associated focal epilepsy

Science China Life Sciences magazine recently reported on the research results of Tang Beisha's team from Xiangya Hospital of Central South University, Liu Jing Yu's team from the Institute of Neurology of the Chinese Academy of Sciences, and Zhang Luoying's team from Huazhong University of Science and Technology, including Du Shiyue, Zeng Sheng, and Song Li. Epilepsy has a complex etiology with 80% owing a genetic basis.

15 Jun 2023

$Study: Hip fracture cases estimated to nearly double by 2050$

Study: Hip fracture cases estimated to nearly double by 2050

An international group of researchers led by the Department of Pharmacology and Pharmacy, LKS Faculty of Medicine, the University of Hong Kong (HKUMed), and including Douglas P Kiel, MD, MPH, Director Musculoskeletal Research Center, Marcus Institute for Aging Research, Hebrew SeniorLife, and Professor of Medicine, Harvard Medical School, evaluated the secular trends in hip fracture incidence, treatment patterns following a hip fracture, and all-cause mortality in 19 countries and regions from 2005 to 2018.

15 Jun 2023

Mapping the evolutionary timeline and population distribution of E. coli’s protective outer capsule

In a new study, published today (15 June) in Nature Communications, a multi-centre team led by the Wellcome Sanger Institute, the University of Oslo, Imperial College London and UCL, has mapped for the first time the evolutionary timeline and population distribution of Escherichia coli’s protective outer capsule, which is responsible for the bacterium’s virulence.

15 Jun 2023

Medicine News and Research

Gut microbiota holds clues to predicting Alzheimer's risk

Destroying the tether of shattered chromosomal fragments may help prevent cancerous mutations

Innovative method to map specific DNA markings could be used for early cancer detection

Overly restricting opioid use during surgery may be doing more harm than good

$1.9 million grant awarded to explore the effect of antifungal drugs in Crohn's patients

BMI not a complete measure of metabolic health, research shows

Bempedoic acid may offer an alternative to the popular cholesterol-lowering drugs

Sleep duration and quality may affect the risk for diabetes

Children with diabetes often fail to use CGM alarms to alert to dangerously low or high blood sugar levels

Women living with PCOS experience greater body image concerns than normal people

Scientist identifies the specific mechanistic cause of life-threatening fungal infections

New approach improves diagnosis of limb-girdle muscular dystrophy

Promising emerging treatment for cardiac arrest patients yields similar results to targeted standard care

Experts develop latest consensus statement on concussion in sport for optimizing the care of athletes

COVID-19 susceptibility mechanism discovered using a newly created tool

Insilico announces new multimodal transformer-based aging clock for processing diverse data sets

UC researchers discover treatment for a rare cancer-like lung disease in women

New findings expand the genotypic spectrum of NPRL3-associated focal epilepsy

Study: Hip fracture cases estimated to nearly double by 2050

Mapping the evolutionary timeline and population distribution of E. coli’s protective outer capsule

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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