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Study may help advance data on oncolytic adenovirus mediated double suicide-gene therapy for high-grade brain tumors

Researchers in the Hermelin Brain Tumor Center at Henry Ford Health are leading a Phase I clinical trial studying the maximum tolerated dose of an oncolytic adenovirus, a mutated virus engineered to selectively replicate in and destroy cancer tissue, in combination with fractionated stereotactic radiosurgery among patients who are undergoing resection of a recurrent high-grade astrocytoma brain tumor.

8 Jun 2023

Cryo-EM reveals key atomic structures of the ends of actin filament

Actin filaments -; protein structures critical to living movement from single cells to animals -; have long been known to have polarity associated with their physical characteristics, with growing "barbed" and shrinking "pointed" ends.

8 Jun 2023

Insilico Medicine nominates pan-TEAD inhibitor as a potential solution for drug resistance in solid tumor patients

Insilico Medicine, a generative artificial intelligence (AI)-driven clinical-stage drug discovery company, today announced the nomination of ISM6331, a potential best-in-class pan-TEAD inhibitor, as a preclinical candidate compound (PCC) generated by Chemistry42, its proprietary generative chemistry-driven molecule design engine, targeting the Hippo pathway for the treatment of advanced solid tumors.

8 Jun 2023

Study provides a new perspective on the aberrant nature of B cell phenotypes in skin cancer

A new study that sheds light on how B cells react to skin cancer cells could pave the way for innovative therapy design.

8 Jun 2023

First-in-class drug shows promise as a safe and effective treatment for cannabis use disorder

A first-in-class drug engineered to selectively inhibit the signaling pathway of the cannabinoid receptor shows promise as a safe and effective treatment for cannabis use disorder (CUD), a condition where a person is unable to control their cannabis use, even though it's causing problems in their lives.

8 Jun 2023

Global study provides high-quality data to improve treatment of newborn babies with sepsis

A global observational study, which involved more than 3,200 newborn babies suffering from sepsis in 19 hospitals in 11 countries, has shown that many newborns are dying because the antibiotics used to treat sepsis are losing their effectiveness.

8 Jun 2023

Experimental drug may slow the progression of atherosclerosis

An experimental drug already tested as a potential treatment for cancer, lung disease, and Alzheimer's disease may slow the progression of atherosclerosis that leads to heart disease, a new study shows.

8 Jun 2023

DNA study sheds light on how we maintain healthy blood sugar levels after meals

A study of the DNA of more than 55,000 people worldwide has shed light on how we maintain healthy blood sugar levels after we have eaten, with implications for our understanding of how the process goes wrong in type 2 diabetes.

8 Jun 2023

Penn Medicine researchers receive $6 million NIH grant to gain new insights on cardiac cellular identity

Historically, scientists have studied how cells develop and give rise to specialized cells, such as heart, liver, or skin cells, by examining specific proteins.

8 Jun 2023

Weak spot discovery could pave way for more effective cancer therapies

Prostate cancer is the most common non-skin cancer in men worldwide. According to international estimates about one in six men will get prostate cancer during their lifetime and worldwide, over 375'000 patients will die from it each year.

8 Jun 2023

UC research examines role of a metabolite in the development of abdominal aortic aneurysm

Each year, about 200,000 people in the United States are diagnosed with a bulge in the lower part of the aorta, the main artery in the body, called an abdominal aortic aneurysm (AAA).

8 Jun 2023

Newly discovered bacterial species can have a major role in causing tooth decay

Collaborating researchers from the University of Pennsylvania School of Dental Medicine and the Adams School of Dentistry and Gillings School of Global Public Health at the University of North Carolina have discovered that a bacterial species called Selenomonas sputigena can have a major role in causing tooth decay.

8 Jun 2023

National experts explore public health information system's strengths, weaknesses, opportunities and threats

The pandemic has placed a spotlight on public health -- its workforce, infrastructure and underlying information systems designed to collect, analyze and manage public health data.

8 Jun 2023

“List diving” contributes to disparities in organ transplantation

A kidney from a deceased donor is supposed to be allocated to the top-ranked patient on a transplant center's waiting list, identified using an objective algorithm to rank patients based on patient age, waiting time, and other factors.

8 Jun 2023

Trial finds mixed success of chatbots in improving COVID-19 vaccine confidence among Asians

Chatbots had mixed success in improving COVID-19 vaccine confidence and acceptance among the most hesitant individuals in Asia, according to a new randomized control trial.

8 Jun 2023

Sebum RNA could provide reliable biomarkers for detecting early-onset atopic dermatitis

Eczema is an inflammatory skin condition that often affects infants as young as one to two months. Among the various types of eczema seen in infants, early-onset atopic dermatitis (AD), characterized by psychological stress and sleep disorders, is particularly concerning.

8 Jun 2023

Insomnia raises the risk of influenza and other respiratory infections

A study based on more than 600 000 participants suggests that insomnia increases the risk of influenza and other respiratory infections.

8 Jun 2023

Heart attack patients with concurrent COVID-19 have higher mortality risk, research shows

New research from the Smidt Heart Institute at Cedars-Sinai shows that patients who went to a hospital with a heart attack and were simultaneously sick with COVID-19 were three times more likely to die than patients experiencing a heart attack without a COVID-19 infection.

8 Jun 2023

New scientific statement details treatment strategies for pediatric cardiomyopathy

Treating children with cardiomyopathy should be personalized based on the root cause, symptoms and progression of the condition in each child , according to a new American Heart Association scientific statement published today in the Association's flagship, peer-reviewed journal Circulation.

8 Jun 2023

University Hospital Centre for Emerging Viral Diseases named as a WHO collaborating center for epidemic and pandemic diseases

The World Health Organization (WHO), the University of Geneva (UNIGE) and Geneva University Hospitals (HUG), yesterday formalized the designation of the University Hospital Centre for Emerging Viral Diseases as a WHO collaborating center for epidemic and pandemic diseases.

8 Jun 2023

Medicine News and Research

Study may help advance data on oncolytic adenovirus mediated double suicide-gene therapy for high-grade brain tumors

Cryo-EM reveals key atomic structures of the ends of actin filament

Insilico Medicine nominates pan-TEAD inhibitor as a potential solution for drug resistance in solid tumor patients

Study provides a new perspective on the aberrant nature of B cell phenotypes in skin cancer

First-in-class drug shows promise as a safe and effective treatment for cannabis use disorder

Global study provides high-quality data to improve treatment of newborn babies with sepsis

Experimental drug may slow the progression of atherosclerosis

DNA study sheds light on how we maintain healthy blood sugar levels after meals

Penn Medicine researchers receive $6 million NIH grant to gain new insights on cardiac cellular identity

Weak spot discovery could pave way for more effective cancer therapies

UC research examines role of a metabolite in the development of abdominal aortic aneurysm

Newly discovered bacterial species can have a major role in causing tooth decay

National experts explore public health information system's strengths, weaknesses, opportunities and threats

“List diving” contributes to disparities in organ transplantation

Trial finds mixed success of chatbots in improving COVID-19 vaccine confidence among Asians

Sebum RNA could provide reliable biomarkers for detecting early-onset atopic dermatitis

Insomnia raises the risk of influenza and other respiratory infections

Heart attack patients with concurrent COVID-19 have higher mortality risk, research shows

New scientific statement details treatment strategies for pediatric cardiomyopathy

University Hospital Centre for Emerging Viral Diseases named as a WHO collaborating center for epidemic and pandemic diseases

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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