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SARS-CoV-2 RNA levels, IFN-1, ISGs, and NF-κB gene responses within the respiratory tract of mild and severe COVID-19 patients

Researchers characterized the expression of IFN-1 and IFN-2, ISGs, and NF-κB in the upper respiratory tracts of patients with mild and severe COVID-19, to understand innate immune responses to SARS-CoV-2 infections.

17 Nov 2022

Potential effects of nonoral versus oral gender-affirming estrogen therapy

A comprehensive review of research into the delivery method of estrogen treatment (e.g., oral, intramuscular injection, transdermal patch, etc.) and cardiovascular risk in transgender women and gender-diverse people found that treatment route may affect heart health, but there is not enough available data for metanalysis. The study is published ahead of print in the American Journal of Physiology-Heart and Circulatory Physiology. It was chosen as an APSselect article for November.

17 Nov 2022

National Institutes of Health funds a five-year, $11 million initiative

The conversations between our bone and muscle change as we age, and both are the weaker for it, Medical College of Georgia scientists say.

17 Nov 2022

Inhibitory neuron dysfunction emerges as a modulable mechanism of hyperexcitability

A small group of brain cells linked in a circuit is responsible for setting off whole-brain seizures in a rare form of epilepsy affected by blood sugar levels, a study led by UT Southwestern researchers suggests. The finding, published in Science Translational Medicine, could lead to new treatments for other metabolic disorders in the brain, the authors said.

17 Nov 2022

Study of natural killer lymphocytes transcriptionally reprogrammed by vaccinia virus

In a recent study posted to the bioRxiv* preprint server, researchers evaluated responses of natural killer (NK) lymphocytes to VACV (vaccinia virus) infections in vivo.

16 Nov 2022

Could self-collected swabs play a role in the diagnosis and control of monkeypox?

In a recent study published in the journal Clinical Infectious Diseases, researchers evaluated the accuracy of patient-collected samples in diagnosing monkeypox virus infections.

16 Nov 2022

SARS-CoV-2 antibodies persist in breast milk following two and three COVID-19 vaccine doses

A new study assesses anti-SARS-CoV-2 antibody levels in breast milk obtained from lactating individuals following two or three COVID-19 vaccine doses.

16 Nov 2022

Researchers discover the mechanism for heart complications from immune checkpoint inhibitors

Myocarditis is a complication that can occur in cancer patients treated with immune checkpoint inhibitors.

16 Nov 2022

Scientists develop new injectable hydrogel for treatment of aneurysms

Aneurysms, abnormal enlargement or ballooning in the wall of blood vessels can result in rupture and fatal bleeding. To treat aneurysms, it is essential to stop the blood flow to the affected area and prevent rupture of the vessel.

16 Nov 2022

Diet containing excess salt can contribute to increased levels of stress, study shows

A diet containing lots of salt can contribute to increased levels of stress, a new study shows.

16 Nov 2022

Study could form the basis of blood testing for people at high risk of breast cancer

Researchers have found changes in the levels of particular proteins in people's blood up to two years before they were diagnosed with breast cancer.

16 Nov 2022

SARS-CoV-2 infection triggers reactivation of latent viruses in people with chronic fatigue syndrome

COVID-19 reactivated viruses that had become latent in cells following previous infections, particularly in people with chronic fatigue syndrome, also known as ME/CFS.

16 Nov 2022

Cambridge scientists use synthetic biology approach to destroy SARS-CoV-2 virus

Cambridge scientists have used synthetic biology to create artificial enzymes programmed to target the genetic code of SARS-CoV-2 and destroy the virus, an approach that could be used to develop a new generation of antiviral drugs.

16 Nov 2022

Whole-genome sequencing reveals five new subgroups of chronic lymphocytic leukemia

A collaborative study led by the University of Oxford as part of the UK's 100,000 Genomes Project, published in Nature Genetics today, has defined five new subgroups of the most common type of blood cancer, chronic lymphocytic leukemia (CLL) and associated these with clinical outcomes.

16 Nov 2022

Research findings could bolster the effectiveness of immune-checkpoint therapy

Immune checkpoint inhibitors such as Keytruda and Opdivo work by unleashing the immune system's T cells to attack tumor cells.

16 Nov 2022

Research reveals new treatment avenue for pediatric high grade gliomas harboring a genetic mutation

Researchers at the University of Michigan Rogel Cancer Center have identified a novel treatment approach to an aggressive type of pediatric brain cancer, using therapies already approved to treat cancer.

16 Nov 2022

Research in young rats shows how hormonal contraceptives may affect the brain

Reproductive health experts consider hormonal contraceptives good choices for adolescents because they're safe and highly effective at preventing pregnancy, but one aspect of their effect on the teenage body remains a mystery – whether and how they modify the developing brain.

16 Nov 2022

Researchers are developing calculator that weighs risk and benefit of taking osteoporosis drugs

Osteoporosis is a major, worsening public health problem and bisphosphonates which help restore a healthier balance of bone production and resorption, have been a relatively inexpensive, successful treatment, particularly for those at highest risk for fractures.

16 Nov 2022

COVID-19 mRNA boosters induce robust but non-durable immune response in the elderly

A study published in the journal Frontiers in Immunology describes that the third booster dose of coronavirus disease 2019 (COVID-19) effectively induces an immune response against immunologically more fit variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the immunity induced by the booster vaccination is transient and gradually declines over time.

15 Nov 2022

Vitamin D can reduce severity and spread of COVID-19

In a recent study published in the Scientific Reports journal, researchers in the United States assessed the relationship between supplementation with vitamin D and coronavirus disease 2019 (COVID-19) and related mortality.

15 Nov 2022

Blood News and Research

SARS-CoV-2 RNA levels, IFN-1, ISGs, and NF-κB gene responses within the respiratory tract of mild and severe COVID-19 patients

Potential effects of nonoral versus oral gender-affirming estrogen therapy

National Institutes of Health funds a five-year, $11 million initiative

Inhibitory neuron dysfunction emerges as a modulable mechanism of hyperexcitability

Study of natural killer lymphocytes transcriptionally reprogrammed by vaccinia virus

Could self-collected swabs play a role in the diagnosis and control of monkeypox?

SARS-CoV-2 antibodies persist in breast milk following two and three COVID-19 vaccine doses

Researchers discover the mechanism for heart complications from immune checkpoint inhibitors

Scientists develop new injectable hydrogel for treatment of aneurysms

Diet containing excess salt can contribute to increased levels of stress, study shows

Study could form the basis of blood testing for people at high risk of breast cancer

SARS-CoV-2 infection triggers reactivation of latent viruses in people with chronic fatigue syndrome

Cambridge scientists use synthetic biology approach to destroy SARS-CoV-2 virus

Whole-genome sequencing reveals five new subgroups of chronic lymphocytic leukemia

Research findings could bolster the effectiveness of immune-checkpoint therapy

Research reveals new treatment avenue for pediatric high grade gliomas harboring a genetic mutation

Research in young rats shows how hormonal contraceptives may affect the brain

Researchers are developing calculator that weighs risk and benefit of taking osteoporosis drugs

COVID-19 mRNA boosters induce robust but non-durable immune response in the elderly

Vitamin D can reduce severity and spread of COVID-19

Decoding Cannabis: Differentiating Hemp and Marijuana

Deciphering the Microbiome with The Microsetta Initiative

Leveraging the power of automation to boost research

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