Lungs News and Research

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MRI-guided focused ultrasound to treat pain from bone metastases

InSightec Ltd, the leader in magnetic resonance imaging guided Focused Ultrasound therapy (MRgFUS), announced that the results of its ExAblate® Phase III clinical trial for treating painful bone metastases have been published online in the JNCI, Journal of National Cancer Institute.

8 May 2014

Children who wheeze are at risk of developing damage that affect lung function

Children who wheeze are at risk of developing damage that will affect their lung function by the age of 6 years, according to researchers at CHU Sainte-Justine Hospital and the University of Montreal.

8 May 2014

WHI: Combined hormone therapy clinical trial yields massive economic return

Economic findings were released today on the Women's Health Initiative (WHI), estrogen plus progestin (E+P) trial.

8 May 2014

Commonly used drug restores blood flow to oxygen-starved muscles of boys with muscular dystrophy

Cedars-Sinai Heart Institute researchers have found that a commonly prescribed drug restores blood flow to oxygen-starved muscles of boys with Duchenne muscular dystrophy, a genetic muscle-wasting disease that rarely is seen in girls but affects one in 3,500 male babies, profoundly shortening life expectancy. It is the most common fatal disease that affects children.

8 May 2014

Scientists find 2 key proteins that regulate growth of mammary stem cells and contribute to breast cancer

By carefully controlling the levels of two proteins, researchers at the Salk Institute have discovered how to keep mammary stem cells-those that can form breast tissue-alive and functioning in the lab. The new ability to propagate mammary stem cells is allowing them to study both breast development and the formation of breast cancers.

8 May 2014

Common drug may improve blood flow in muscles of boys with Duchenne muscular dystrophy

A drug typically prescribed for erectile dysfunction or increased pressure in the arteries may help improve blood flow in the muscles of boys with Duchenne muscular dystrophy, according to a study published in the May 7, 2014, online issue of Neurology®, the medical journal of the American Academy of Neurology.

8 May 2014

Ambrisentan cleared for use with phenprocoumon

Starting treatment with ambrisentan does not necessitate adjusting the dose of the oral anticoagulant phenprocoumon in patients with pulmonary hypertension who require both medications, report researchers.

7 May 2014

Triple therapy shows promise for severe PAH

Results of a small pilot study among patients with severe pulmonary arterial hypertension support the long-term benefits of upfront triple combination therapy, French researchers report.

7 May 2014

ARIAD provides update on corporate developments, reports Q1 2014 financial results

ARIAD Pharmaceuticals, Inc. today reported financial results for the first quarter of 2014, including revenue from sales of Iclusig® (ponatinib) and licensing agreements. The Company also provided an update on corporate developments.

7 May 2014

Protein molecule seems to slow progression of deadly lung disease

Researchers at the University of Illinois at Chicago College of Medicine have discovered a protein molecule that seems to slow the progression of pulmonary fibrosis, a progressive lung disease that is often fatal three to five years after diagnosis.

7 May 2014

Inflammatory pneumococcal response differs by age

The composition of inflammatory lung infiltrate in people with pneumonia caused by Streptococcus pneumoniae differs by age, an in-situ study reveals.

6 May 2014

Mortality after cardiac surgery: an interview with Dr. Bryan G. Maxwell, Johns Hopkins Medicine

The last decade has seen a strong movement towards the use of various quality measurements to grade medical care. In surgery, 30-day mortality is one of the most common benchmarks. We wanted to determine if patterns of postoperative mortality showed any signs that the process of measuring medical care might actually alter how (and when) care is provided or withdrawn.

6 May 2014

FDA accepts Merck's MK-3475 BLA for review

Merck, known as MSD outside the United States and Canada, today announced that the U.S. Food and Drug Administration has accepted for review the Biologics License Application (BLA) for MK-3475, Merck's investigational anti-PD-1 antibody, for the treatment of unresectable or metastatic melanoma in patients who have been previously treated with ipilimumab.

6 May 2014

Rat pups exposed to tobacco smoke are at higher risk of developing metabolic disease

While many parents-to-be are aware that the health of their baby starts before they've actually arrived into the world, recent research reveals that "harm" (i.e., tobacco smoke, dirty air, poor nutrition, even preeclampsia) may not present itself disease-wise until well into adulthood or when a second harmful "hit" triggers the individual's susceptibility.

6 May 2014

Bristol-Myers Squibb to present new immunotherapy study data at ASCO Annual Meeting

Bristol-Myers Squibb Company today announced that new data from studies investigating its immunotherapies in adjuvant and advanced melanoma, non-small cell lung cancer (NSCLC) and metastatic renal cell carcinoma (mRCC) will be presented at the 50th Annual Meeting of the American Society of Clinical Oncology (ASCO) in Chicago from May 30-June 3.

6 May 2014

NCCN publishes new patient resource for stage 0 breast cancer

The National Comprehensive Cancer Network (NCCN), with the support of the NCCN Foundation®, announces the availability of the NCCN Guidelines for Patients: Breast Cancer Stages 0 - IV—the latest addition to the library of NCCN Guidelines for Patients available online free-of-charge at NCCN.org/patients.

6 May 2014

UH biomedical engineer receives ALR grant to study cause of lupus nephritis

In the U.S. alone, more than 1.5 million people have lupus, a chronic autoimmune disease in which the immune system turns against itself, attacking a person's healthy tissue, cells and organs. The symptoms can range from debilitating pain and fatigue to organ failure.

6 May 2014

Scientists develop bone marrow-on-a-chip to test effects of new drugs, toxic agents on bone marrow

The latest organ-on-a-chip from Harvard's Wyss Institute for Biologically Inspired Engineering reproduces the structure, functions and cellular make-up of bone marrow, a complex tissue that until now could only be studied intact in living animals, Institute researchers report in the May 4, 2014, online issue of Nature Methods.

6 May 2014

MEI Pharma begins ME-344 Phase Ib clinical study in patients with solid tumors

MEI Pharma, Inc., an oncology company focused on the clinical development of novel therapies for cancer, announced today that the first patient has been dosed in a Phase Ib clinical study of its investigational mitochondrial inhibitor drug candidate ME-344 in combination with Hycamtin (topotecan) in patients with solid tumors, including small cell lung and ovarian cancers.

6 May 2014

Research roundup: Compounding pharmacies; marketplace details; changes in insurance coverage

Outraged over a 2012 fungal meningitis outbreak traced back to Framingham, Massachusetts-based drug compounder New England Compounding Center (NECC) that left sixty-four people dead and more than 700 sickened, Congress passed the Compounding Quality Act .

5 May 2014

Lungs News and Research

MRI-guided focused ultrasound to treat pain from bone metastases

Children who wheeze are at risk of developing damage that affect lung function

WHI: Combined hormone therapy clinical trial yields massive economic return

Commonly used drug restores blood flow to oxygen-starved muscles of boys with muscular dystrophy

Scientists find 2 key proteins that regulate growth of mammary stem cells and contribute to breast cancer

Common drug may improve blood flow in muscles of boys with Duchenne muscular dystrophy

Ambrisentan cleared for use with phenprocoumon

Triple therapy shows promise for severe PAH

ARIAD provides update on corporate developments, reports Q1 2014 financial results

Protein molecule seems to slow progression of deadly lung disease

Inflammatory pneumococcal response differs by age

Mortality after cardiac surgery: an interview with Dr. Bryan G. Maxwell, Johns Hopkins Medicine

FDA accepts Merck's MK-3475 BLA for review

Rat pups exposed to tobacco smoke are at higher risk of developing metabolic disease

Bristol-Myers Squibb to present new immunotherapy study data at ASCO Annual Meeting

NCCN publishes new patient resource for stage 0 breast cancer

UH biomedical engineer receives ALR grant to study cause of lupus nephritis

Scientists develop bone marrow-on-a-chip to test effects of new drugs, toxic agents on bone marrow

MEI Pharma begins ME-344 Phase Ib clinical study in patients with solid tumors

Research roundup: Compounding pharmacies; marketplace details; changes in insurance coverage

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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