Amyotrophic Lateral Sclerosis News and Research

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Knopp and NIAID collaborate to investigate eosinophil-lowering effects of dexpramipexole

Knopp Biosciences LLC today announced a second collaboration with the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), to investigate the eosinophil-lowering effects of the investigational drug dexpramipexole.

13 Mar 2014

New findings shed light on how gene mutation causes motor neurone disease

Researchers have discovered a mechanism that may explain how a recently discovered mutation causes two devastating neurological diseases.

6 Mar 2014

New findings shed light on how gene mutation causes motor neurone disease

Researchers have discovered a mechanism that may explain how a recently discovered mutation causes two devastating neurological diseases.

6 Mar 2014

Scientists reveal how a genetic code variation results in devastating brain diseases

New findings reveal how a mutation, a change in the genetic code that causes neurodegeneration, alters the shape of DNA, making cells more vulnerable to stress and more likely to die.

6 Mar 2014

Stem cells from patients offer model, drug-discovery platform for early-onset form of Alzheimer's

Harvard stem cell scientists have successfully converted skins cells from patients with early-onset Alzheimer's into the types of neurons that are affected by the disease, making it possible for the first time to study this leading form of dementia in living human cells. This may also make it possible to develop therapies far more quickly and accurately than before.

5 Mar 2014

Neuroscientists unlock a piece of puzzle in fight against Lou Gehrig's disease

Keck School of Medicine of USC neuroscientists have unlocked a piece of the puzzle in the fight against Lou Gehrig's disease, a debilitating neurological disorder that robs people of their motor skills.

4 Mar 2014

Genervon's GM604 bio-drug receives FDA orphan drug designation for ALS treatment

Genervon Biopharmaceuticals announced today that the U.S. Food and Drug Administration has granted an "orphan drug" designation to Genervon's GM604 (a.k.a. GM6) bio-drug for the treatment of Amyotrophic Lateral Sclerosis (ALS). The FDA also granted GM604 a "fast-track" designation for ALS in 2013.

3 Mar 2014

High-carbohydrate, high-calorie diet could delay progression of Amyotrophic Lateral Sclerosis

A high-carbohydrate, high-calorie diet could delay the progression of Amyotrophic Lateral Sclerosis (ALS), also known as motor neuron disease or Lou Gehrig’s disease, according to a phase 2 study published in The Lancet.

3 Mar 2014

Organizations involved in assisted suicide help women die more frequently than men

Organisations involved in assisted suicide help women die more frequently than men. In addition, those living alone, the divorced and well-educated people make above-average use of assisted suicide.

19 Feb 2014

LA Fitness to host in-club Group Fitness class in support of Augie's Quest

In support of Augie's Quest, LA Fitness announced today that it will host an in-club Group Fitness class at more than 500 of the company's locations on February 22, 2014. Augie's Quest is a nonprofit research initiative dedicated to finding treatments and a cure for amyotrophic lateral sclerosis (ALS). LA Fitness has donated to Augie's Quest for several years, and this year's fundraiser marks the fourth in-club event the company has held in support of this worthy cause.

13 Feb 2014

UMMS launches Voyager Therapeutics to develop life-changing treatments for fatal diseases

UMass Medical School (UMMS) recognizes the launch today of Voyager Therapeutics, a gene therapy company founded by four world leaders in the fields of AAV gene therapy, RNA biology and neuroscience, to develop life-changing treatments for fatal and debilitating diseases of the central nervous system (CNS).

13 Feb 2014

Prions and their shadow proteins: an interview with Dr Jiri Safar, Co-Director of the National Prion Disease Pathology Surveillance Center

The prion diseases were originally discovered by Dr Gajdusek and Dr Gibbs. The first disease discovered was Kuru, which was affecting native tribes in the Papua New Guinea highlands in the 1950s.

9 Feb 2014

DP stimulation in spinal cord-injured patients is successful in weaning patients from mechanical ventilators

A new study published in the Journal of Trauma and Acute Care Surgery finds that diaphragm pacing (DP) stimulation in spinal cord-injured patients is successful not only in weaning patients from mechanical ventilators but also in bridging patients to independent respiration, where they could breathe on their own without the aid of a ventilator or stimulation.

9 Feb 2014

Researchers identify protein that regulates how genetic information transcribed from DNA to mRNA

Molecular biologists from Indiana University are part of a team that has identified a protein that regulates the information present in a large number of messenger ribonucleic acid molecules that are important for carrying genetic information from DNA to protein synthesis.

7 Feb 2014

Researchers examine how toxin triggers motor neuron death

In most cases of amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease, a toxin released by cells that normally nurture neurons in the brain and spinal cord can trigger loss of the nerve cells affected in the disease, Columbia researchers reported today in the online edition of the journal Neuron.

7 Feb 2014

Study offers new avenue to pursue in quest for desperately needed treatments for ALS

St. Jude Children's Research Hospital scientists led a study showing that mutations in a gene responsible for amyotrophic lateral sclerosis (ALS) disrupt the RNA transport system in nerve cells.

6 Feb 2014

UC San Diego researchers uncover causes for hereditary spastic paraplegia

In a study published in the January 31, 2014 issue of Science, an international team led by scientists at the University of California, San Diego School of Medicine report doubling the number of known causes for the neurodegenerative disorder known as hereditary spastic paraplegia. HSP is characterized by progressive stiffness and contraction of the lower limbs and is associated with epilepsy, cognitive impairment, blindness and other neurological features.

31 Jan 2014

Loyola University neuropsychologist find little evidence that chronic traumatic encephalopathy actually exists

The media have widely reported that a debilitating neurological condition called chronic traumatic encephalopathy is a well-established disease in retired athletes who played football and other contact sports.

28 Jan 2014

CUMC researchers identify gene that appears to play major role in motor neuron degeneration in ALS

Columbia University Medical Center researchers have identified a gene, called matrix metalloproteinase-9 (MMP-9), that appears to play a major role in motor neuron degeneration in amyotrophic lateral sclerosis, also known as Lou Gehrig's disease. The findings, made in mice, explain why most but not all motor neurons are affected by the disease and identify a potential therapeutic target for this still-incurable neurodegenerative disease. The study was published today in the online edition of the journal Neuron.

23 Jan 2014

New orthotic device could aid in rehabilitation of patients with ankle-foot disorders

A soft, wearable device that mimics the muscles, tendons and ligaments of the lower leg could aid in the rehabilitation of patients with ankle-foot disorders such as drop foot, said Yong-Lae Park, an assistant professor of robotics at Carnegie Mellon University.

22 Jan 2014

Amyotrophic Lateral Sclerosis News and Research

Knopp and NIAID collaborate to investigate eosinophil-lowering effects of dexpramipexole

New findings shed light on how gene mutation causes motor neurone disease

New findings shed light on how gene mutation causes motor neurone disease

Scientists reveal how a genetic code variation results in devastating brain diseases

Stem cells from patients offer model, drug-discovery platform for early-onset form of Alzheimer's

Neuroscientists unlock a piece of puzzle in fight against Lou Gehrig's disease

Genervon's GM604 bio-drug receives FDA orphan drug designation for ALS treatment

High-carbohydrate, high-calorie diet could delay progression of Amyotrophic Lateral Sclerosis

Organizations involved in assisted suicide help women die more frequently than men

LA Fitness to host in-club Group Fitness class in support of Augie's Quest

UMMS launches Voyager Therapeutics to develop life-changing treatments for fatal diseases

Prions and their shadow proteins: an interview with Dr Jiri Safar, Co-Director of the National Prion Disease Pathology Surveillance Center

DP stimulation in spinal cord-injured patients is successful in weaning patients from mechanical ventilators

Researchers identify protein that regulates how genetic information transcribed from DNA to mRNA

Researchers examine how toxin triggers motor neuron death

Study offers new avenue to pursue in quest for desperately needed treatments for ALS

UC San Diego researchers uncover causes for hereditary spastic paraplegia

Loyola University neuropsychologist find little evidence that chronic traumatic encephalopathy actually exists

CUMC researchers identify gene that appears to play major role in motor neuron degeneration in ALS

New orthotic device could aid in rehabilitation of patients with ankle-foot disorders

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