Lipoprotein News and Research

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A lipoprotein is a biochemical assembly that contains both proteins and lipids. The lipids or their derivatives may be covalently or non-covalently bound to the proteins.

Researchers uncover how GWAS-implicated gene affects HDL-cholesterol levels

Researchers have uncovered how genes identified from genome-wide association studies (GWAS) affect high-density lipoprotein cholesterol (HDL-C), a biomarker of cardiovascular disease, after comparing several animal models with human patient data.

10 Aug 2016

Small dense HDL particles protectively linked to coronary heart disease risk

The idea that plasma high-density lipoprotein cholesterol (HDL-C) is protective against coronary heart disease has been part of medical conventional wisdom for five decades.

3 Aug 2016

Accelerated cardiovascular risk in patients with FH phenotype

Patients with levels of low-density lipoprotein cholesterol normally seen in familial hypercholesterolaemia have the cardiovascular risk of someone decades older than they are, shows a population-based study.

4 Jul 2016

Comprehensive NMR profiling module for detailed lipoprotein subclass analysis announced by Bruker (research use only)

At the 12th Annual Conference of the Metabolomics Society (www.metabolomics2016.org), Bruker announces a new, more comprehensive, more efficient and easy-to-use profiling module for detailed lipoprotein subclass analysis using Nuclear Magnetic Resonance (NMR).

From Bruker BioSpin - NMR, EPR and Imaging 1 Jul 2016

Pharmacotherapy reduces conduction system disease risk

Lisinopril therapy significantly reduces incident conduction system disease, indicates a post-hoc analysis of ALLHAT data.

28 Jun 2016

Older adults with high LDL-C live longer than peers with low levels of same cholesterol, say experts

A University of South Florida professor and an international team of experts have found that older people with high levels of a certain type of cholesterol, known as low-density lipoprotein (LDL-C), live as long, and often longer, than their peers with low levels of this same cholesterol.

27 Jun 2016

Real-world analysis questions very low LDL targets

Patients treated for hypercholesterolaemia in clinical practice may not derive additional benefit from very intensive statin treatment, say researchers.

22 Jun 2016

Researchers highlight gene loss as potential process of genetic change, evolutionary adaption

"Loss is nothing else but change and change is nature's delight" says the quote by the philosopher and emperor Marcus Aurelius, which opens the scientific article that analyses the gene loss phenomenon and its impact on the evolution of living beings.

16 Jun 2016

Prospective biobank studies with genetic data can help improve drug development, reduce costs

With drug development costs topping $1.2bn (£850 million) to get a single treatment to the point it can be sold and used in the clinic, could genetic analysis save hundreds of millions of dollars?

15 Jun 2016

Weight reduction surgery improves serum lipids in obese patients

Fifty years after the first reported partial-ileal bypass, metabolic surgery has an established role in achieving weight loss and reducing cardiovascular death in obese patients.

15 Jun 2016

Behavioural intervention could be effective way to improve health of RA patients

The results of a study presented today at the European League Against Rheumatism Annual Congress showed for the first time that a combination of text messages and individual counselling sessions to motivate patients with Rheumatoid Arthritis (RA) to be more active resulted in improved patient-reported clinical outcomes.

13 Jun 2016

Barley products lower levels of two types of bad cholesterol linked to cardiovascular risk

Eating barley or foods containing barley significantly reduced levels of two types of "bad cholesterol" associated with cardiovascular risk, a St. Michael's Hospital research paper has found.

8 Jun 2016

Microvascular disease burden tied to CVD outcomes in diabetic patients

The risk of cardiovascular disease events in patients with Type 2 diabetes rises in line with their cumulative burden of microvascular disease, research shows.

25 May 2016

Novel protective gene against CAD uncovered

A large study has found that mutations in the gene encoding the major subunit of the asialoglycoprotein receptor are protective against coronary artery disease.

20 May 2016

Raised lipoprotein(a) could account for a quarter of FH cases

High levels of lipoprotein(a) could account for a substantial proportion of cases of familial hypercholesterolaemia, a large study shows.

20 May 2016

Model may guide statin treatment in diabetes patients

Researchers have developed a model to predict the benefits of statin treatment in individual patients with Type 2 diabetes, but experts question whether individualised treatment is always the best choice.

17 May 2016

Videogame addiction may impact sleep habits, obesity and cardio-metabolic health among children and teens

Some children and youth with high videogame addiction tendencies may be at risk of sleep deprivation and disorders associated with obesity and poor cardio-metabolic health, Hamilton researchers have found.

10 May 2016

First generic version of Crestor gets FDA approval

The U.S. Food and Drug Administration today approved the first generic version of Crestor (rosuvastatin calcium) tablets.

30 Apr 2016

Sleep loss influences cholesterol metabolism, study finds

Lack of sleep has previously been found to impact the activation of the immune system, inflammation, carbohydrate metabolism and the hormones that regulate appetite. Now University of Helsinki researchers have found that sleep loss also influences cholesterol metabolism.

22 Apr 2016

Adolescent obesity linked to elevated risk of cardiovascular mortality in midlife

A nationwide study of 2.3 million Israeli adolescents, examined from 1967 through 2010, finds an association between elevated body-mass index in late adolescence, and subsequent cardiovascular mortality in midlife.

16 Apr 2016