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Genetic profiles obtained from nasal passages guide individualized therapy, research

It has become increasingly clear in recent years that asthma comes in several variations, with different causes, different pathologies and different responses to therapy.

20 Feb 2014

Indacaterol/glycopyrronium drug combination offers added benefit for adults with COPD

The drug combination indacaterol/glycopyrronium (trade name: Ultibro Breezhaler, Xoterna Breezhaler) has been approved since September 2013 for adults with chronic obstructive pulmonary disease (COPD).

19 Feb 2014

Driver mutations found in more than half of adenosquamous lung carcinomas

Analysis of a large cohort of Chinese patients with adenosquamous lung carcinoma has identified known mutant kinases in more than half of the tumours, researchers report in the Journal of Thoracic Oncology.

19 Feb 2014

Nintedanib plus docetaxel shows second-line efficacy in recurrent NSCLC

Nintedanib plus docetaxel offers significant efficacy in patients with non-small-cell lung cancer who experience disease progression after first-line chemotherapy, phase III study results show.

19 Feb 2014

Winnie Palmer Hospital for Women & Babies opens neonatal intensive care unit

Winnie Palmer Hospital for Women & Babies is opening the doors to an expansion of its neonatal intensive care unit (NICU). The expansion, which adds 30 beds to the hospital's existing 112-bed NICU, will make it the largest NICU in the world under one roof.

19 Feb 2014

Antibiotics prescribed for children who have URIs does not prevent complications

Antibiotics are often prescribed for young children who have upper respiratory tract infections (URIs) in order to prevent complications, such as ear infections and pneumonia, however, a new evidence review in The Cochrane Library found no evidence to support this practice.

19 Feb 2014

Ajoene in garlic prevents bacteria from destroying white blood cells

Aggressive multi-resistant infections constitute an increasing health problem all over the world. Bacteria are developing resistance at an alarming pace, so new pharmaceuticals that can combat this threat are in great demand.

19 Feb 2014

COPD sufferers can reduce risk of being hospitalized by walking 3 kilometers a day

New research in Respirology shows that suffers of Chronic obstructive pulmonary disease (COPD) can reduce their risk of being hospitalized with severe attacks, by maintaining an exercise regime of walking between three to six kilometers a day.

19 Feb 2014

IGF1R linked to mutation-negative lung cancer erlotinib resistance

Activation of the insulin-like growth factor 1 receptor plays a key role in acquired resistance to erlotinib in lung cancer with wild-type epidermal growth factor receptor, research suggests.

18 Feb 2014

New drug patent may help overcome problems associated with MDR-TB

A chemist based at the University of Copenhagen has just taken out a patent for a drug that can make previously multidrug-resistant bacteria once again responsive to antibiotics.

18 Feb 2014

New approach for delivering vaccines and for stimulating body's immune system to attack tumors

Many vaccines, including those for influenza, polio, and measles, consist of a killed or disabled version of a virus. However, for certain diseases, this type of vaccine is ineffective, or just too risky.

18 Feb 2014

Afatinib ‘first line’ for advanced mutation-positive lung cancer

Afatinib should be given as a first-line treatment for Asian patients with advanced, epidermal growth factor receptor mutation-positive, non-small-cell lung cancer, researchers recommend.

17 Feb 2014

Children exposed to cigarette smoke may have lesser response to asthma treatment

Children exposed to cigarette smoke at home have lower levels of an enzyme that helps them respond to asthma treatment, a study has found.

17 Feb 2014

Study explains clinical, public health challenges for use of statins in treatment of heart attacks

Charles H. Hennekens, M.D., Dr.P.H., the first Sir Richard Doll professor and senior academic advisor to the dean, and Ira J. Gelb, M.D., emeritus professor of cardiology and senior advisor to the dean for pre-baccalaureate programs at FAU's Charles E. Schmidt College of Medicine, have published an invited editorial in the current issue of Cardiology about the clinical and public health challenges to increase utilization of statins in the treatment and prevention of heart attacks and strokes.

17 Feb 2014

Doctors miss opportunities to diagnose COPD at an earlier stage in primary and secondary care

A retrospective study of almost 39,000 patients shows that opportunities to diagnose chronic obstructive pulmonary disease (COPD) at an earlier stage are frequently being missed in both primary and secondary care in the UK. The findings, published in The Lancet Respiratory Medicine, reveal missed opportunities to diagnose COPD occurred in up to 85% of people.

17 Feb 2014

Scientists discover novel antibody-based therapy that targets progression of kidney fibrosis

Scientists from the University of Sheffield have developed a novel antibody-based therapy which targets the progression of life threating kidney fibrosis.

16 Feb 2014

New study documents frequency of EGFR mutations in lung adenocarcinoma in Asian population

Adenocarcinoma histology, female sex, never-smoking status, and Asian ethnicity have been considered the most important factors associated with EGFR mutations in non-small cell lung cancer and response to EGFR inhibitors. A recent study has found that, within the Asian population, the frequency of EGFR mutations associated with other demographic and clinical characteristics is higher than previously reported, even in patients with a history of smoking, suggesting that mutation testing should be done on a broader basis among Asian patients with advanced adenocarcinoma of the lung.

16 Feb 2014

Study affirms new standard for detecting melanoma metastasis to the lymph nodes

Long-term research that was initiated at UCLA's Jonsson Comprehensive Cancer Center on lymphatic mapping and sentinel-node biopsy, techniques for detecting the earliest spread (metastasis) of melanoma, the deadliest form of skin cancer, has confirmed that these techniques significantly prolong patients' disease-free and melanoma-specific survival over the traditional observational "watch and wait" techniques.

14 Feb 2014

Elusive progenitor cells that give rise to ILCs identified in fetal liver and bone marrow of mice

The elusive progenitor cells that give rise to innate lymphoid cells-a recently discovered group of infection-fighting white blood cells-have been identified in fetal liver and adult bone marrow of mice, researchers from the University of Chicago report early online in the journal Nature.

14 Feb 2014

First record of direct link between Alzheimer's disease and elevated brain aluminium

Research at Keele University in Staffordshire, UK, has shown for the first time that an individual who was exposed to aluminium at work and died of Alzheimer's disease had high levels of aluminium in the brain.

14 Feb 2014

Lungs News and Research

Genetic profiles obtained from nasal passages guide individualized therapy, research

Indacaterol/glycopyrronium drug combination offers added benefit for adults with COPD

Driver mutations found in more than half of adenosquamous lung carcinomas

Nintedanib plus docetaxel shows second-line efficacy in recurrent NSCLC

Winnie Palmer Hospital for Women & Babies opens neonatal intensive care unit

Antibiotics prescribed for children who have URIs does not prevent complications

Ajoene in garlic prevents bacteria from destroying white blood cells

COPD sufferers can reduce risk of being hospitalized by walking 3 kilometers a day

IGF1R linked to mutation-negative lung cancer erlotinib resistance

New drug patent may help overcome problems associated with MDR-TB

New approach for delivering vaccines and for stimulating body's immune system to attack tumors

Afatinib ‘first line’ for advanced mutation-positive lung cancer

Children exposed to cigarette smoke may have lesser response to asthma treatment

Study explains clinical, public health challenges for use of statins in treatment of heart attacks

Doctors miss opportunities to diagnose COPD at an earlier stage in primary and secondary care

Scientists discover novel antibody-based therapy that targets progression of kidney fibrosis

New study documents frequency of EGFR mutations in lung adenocarcinoma in Asian population

Study affirms new standard for detecting melanoma metastasis to the lymph nodes

Elusive progenitor cells that give rise to ILCs identified in fetal liver and bone marrow of mice

First record of direct link between Alzheimer's disease and elevated brain aluminium

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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