Lipoprotein News and Research

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A lipoprotein is a biochemical assembly that contains both proteins and lipids. The lipids or their derivatives may be covalently or non-covalently bound to the proteins.

New sensitive detection method could help measure subfractions of HDL

High-density lipoprotein (HDL) is often referred to as good cholesterol: high levels of HDL are associated with lower risk of cardiovascular disease. But many clinical outcome trials for drugs that raise HDL levels have failed to show significant benefits for trial participants.

12 Apr 2016

Health benefits of gastric bypass surgery start soon after procedure

The health benefits of Roux-en Y gastric bypass surgery—a surgical weight-loss procedure in which the stomach is made smaller—start soon after the procedure. New research presented today at the Experimental Biology 2016 meeting in San Diego found that patients who underwent the procedure already showed some reductions in weight, waist circumference and body mass index one week after the procedure.

7 Apr 2016

Study demonstrates rarity of familial hypercholesterolemia mutations in individuals with high cholesterol

Only a small fraction of people with very high cholesterol can attribute their condition to a genetic mutation related to familial hypercholesterolemia, but individuals with these mutations face a high risk of developing early-onset coronary artery disease, according to research presented at the American College of Cardiology's 65th Annual Scientific Session.

4 Apr 2016

Researchers compare lipid-lowering efficacy for two nonstatin therapies in statin-intolerant patients

Steven E. Nissen, M.D., of the Cleveland Clinic, and colleagues identified patients with muscle-related adverse effects from statins and compared lipid-lowering efficacy for two nonstatin therapies, ezetimibe and evolocumab. The study was published online by JAMA, and is being released to coincide with its presentation at the American College of Cardiology's 65th Annual Scientific Session & Expo.

4 Apr 2016

Cholesterol drug evacetrapib fails to reduce risk of cardiovascular events

Despite lowering low-density lipoprotein (LDL), known as "bad" cholesterol, while markedly increasing levels of high-density lipoprotein (HDL), or "good" cholesterol, a large clinical trial to investigate the cholesterol drug evacetrapib was discontinued early after a preliminary analysis showed it did not reduce rates of major adverse cardiovascular events, according to research presented at the American College of Cardiology's 65th Annual Scientific Session.

4 Apr 2016

Synthetic nanoparticle can light up and treat atherosclerotic plaques

Atherosclerosis, a disease in which plaque builds up inside arteries, is a prolific and invisible killer, but it may soon lose its ability to hide in the body and wreak havoc. Scientists have now developed a nanoparticle that functionally mimics nature's own high-density lipoprotein (HDL). The nanoparticle can simultaneously light up and treat atherosclerotic plaques that clog arteries. Therapy with this approach could someday help prevent deadly heart attacks and strokes.

14 Mar 2016

Lots of 'good' cholesterol may be bad

Recent research has identified a genetic mutation that prevents high-density-lipoprotein (HDL) cholesterol from being taken up by cells.

11 Mar 2016

New RI-MUHC-led study may change the way we think about prescribing statins

Millions of people today take statins to help lower their cholesterol level. Currently statins are prescribed to patients based on their future risk of cardiovascular disease - mainly driven by age - which excludes many individuals who may benefit from them. A new study led by the Research Institute of the McGill University Health Centre in Montreal, with collaborators from the United-States, is changing the way we think about prescribing statins. The research team has developed a new approach to determine which individuals should receive these important medications.

11 Mar 2016

Specific gene mutation may significantly reduce risk of heart attack

People with a specific gene mutation have a 50 percent lower risk of suffering a heart attack. This is what an international team of researchers headed by the cardiologist Prof. Heribert Schunkert, Medical Director of the German Heart Center at the Technical University of Munich (TUM), discovered in a broad comparative study. If this gene were switched off with medications it could reduce the risk of coronary disease significantly.

10 Mar 2016

Moderate alcohol consumption can increase risk of heart attack and stroke

While the protective connection between moderate alcohol consumption and heart health has been well-studied, new research from Beth Israel Deaconess Medical Center and the Harvard T. H. Chan School of Public Health suggests that the association is more complicated than is widely accepted.

4 Mar 2016

Genetic errors may reduce heart attack risk, study finds

To reduce risk of heart attack, the benefits of a healthy lifestyle are clear. But genetics can still stack the deck. Some people's genes bestow a natural advantage — or disadvantage — in protecting against heart disease, the leading cause of death worldwide.

3 Mar 2016

UAB researchers focus on five key areas to improve care of CVD patients

According to the Centers for Disease Control and Prevention, approximately 610,000 people die of heart disease in the United States every year — that's one in every four deaths. The impact of cardiovascular diseases is quite large.

28 Feb 2016

PCSK9-inhibitor drugs: A game-changer for individuals with extremely high cholesterol levels

A 59-year-old heart patient with dangerously high levels of cholesterol that could not be adequately reduced by statin drugs now has near-normal cholesterol levels, thanks to a new class of drugs that grew out of work done by UT Southwestern Medical Center researchers.

27 Feb 2016

Tackling insulin resistance may reduce recurrence after stroke

Giving pioglitazone to stroke survivors with insulin resistance but no overt diabetes reduces their risk of having a recurrent vascular event, shows the randomised Insulin Resistance Intervention after Stroke trial.

18 Feb 2016

Study identifies FGF21 protein as potential therapeutic agent for cardiovascular diseases, type 2 diabetes

New research on the blood lipid-lowering protein FGF21 shows how it redistributes fatty acids by two distinct mechanisms. The discovery could lead to improved pharmaceutical treatment for type 2 diabetes and other obesity-related diseases.

11 Feb 2016

Vanderbilt physicians examine risk factors for cardiovascular disease in prostate cancer survivors

The 3 million prostate cancer survivors in the United States are likely to die from something other than cancer, thanks to early detection, effective treatment and the disease's slow progression.

11 Feb 2016

Study sheds light on role of red raspberries in metabolically-based chronic diseases

Components in red raspberries may have anti-inflammatory, anti-oxidative and metabolic stabilizing activity, according to a comprehensive review of the available scientific literature published in the January issue of Advances in Nutrition.

10 Feb 2016

Study provides new insight into complex interchange that can raise blood levels of fat in type 1 diabetes

Researchers have new insight into the complex interchange that can raise blood levels of unhealthy lipids, or fat, in type 1 diabetes, and early evidence that a drug under study to block cancer cell growth can restore healthier levels.

8 Feb 2016

Incidence and severity emerging CVD risk factors may differ between genders

The incidence and severity of both traditional and emerging cardiovascular disease (CVD) risk factors as well as the response to treatment may differ between genders. In this narrative review, several emerging CVD risk factors (i.e. inflammatory and haemostatic markers, endothelial dysfunction, homocysteine, lipid disorders, microalbuminuria/proteinuria, coronary artery calcium score, arterial stiffness, periodontitis, inflammatory bowel syndrome, obstructive sleep apnea, impaired glucose metabolism, metabolic syndrome and non-alcoholic fatty liver disease) are discussed in the context of gender differences.

5 Feb 2016

Weight loss programs that provide healthy fats have similar impacts on pound-shedding

A University of California, San Diego School of Medicine study finds that weight loss programs that provide healthy fats, such as olive oil in the Mediterranean diet, or a low-fat, high-carbohydrate diet have similar impacts on pound-shedding.

29 Jan 2016

Lipoprotein News and Research

Further Reading

New sensitive detection method could help measure subfractions of HDL

Health benefits of gastric bypass surgery start soon after procedure

Study demonstrates rarity of familial hypercholesterolemia mutations in individuals with high cholesterol

Researchers compare lipid-lowering efficacy for two nonstatin therapies in statin-intolerant patients

Cholesterol drug evacetrapib fails to reduce risk of cardiovascular events

Synthetic nanoparticle can light up and treat atherosclerotic plaques

Lots of 'good' cholesterol may be bad

New RI-MUHC-led study may change the way we think about prescribing statins

Specific gene mutation may significantly reduce risk of heart attack

Moderate alcohol consumption can increase risk of heart attack and stroke

Genetic errors may reduce heart attack risk, study finds

UAB researchers focus on five key areas to improve care of CVD patients

PCSK9-inhibitor drugs: A game-changer for individuals with extremely high cholesterol levels

Tackling insulin resistance may reduce recurrence after stroke

Study identifies FGF21 protein as potential therapeutic agent for cardiovascular diseases, type 2 diabetes

Vanderbilt physicians examine risk factors for cardiovascular disease in prostate cancer survivors

Study sheds light on role of red raspberries in metabolically-based chronic diseases

Study provides new insight into complex interchange that can raise blood levels of fat in type 1 diabetes

Incidence and severity emerging CVD risk factors may differ between genders

Weight loss programs that provide healthy fats have similar impacts on pound-shedding

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