Medicinal Chemistry News and Research

RSS

Bristol-Myers Squibb collaborates with Isis Pharmaceuticals

Bristol-Myers Squibb Company and Isis Pharmaceuticals have announced a collaboration to discover, develop and commercialize novel antisense drugs targeting proprotein convertase subtilisin kexin 9 (PCSK9) for the prevention and treatment of cardiovascular disease.

10 May 2007

Prenatal toxicity linked to immune dysfunctions in later life

A Cornell researcher and his wife have conducted the first comprehensive review of later-life diseases that develop in people who were exposed to environmental toxins or drugs either in the womb or as infants.

4 May 2007

Purdue molecule could lead to first drug treatment for Alzheimer's disease

A molecule designed by a Purdue University researcher could lead to the first drug treatment for Alzheimer's disease.

18 Apr 2007

Malaria-infected mice cured by one dose of new drug from Johns Hopkins

Johns Hopkins University researchers have cured malaria-infected mice with single shots of a new series of potent, long lasting synthetic drugs modeled on an ancient Chinese herbal folk remedy.

18 Apr 2007

Use of computer-assisted drug design in drug discovery

Metabasis Therapeutics has announced that on March 27, 2007 at the American Chemical Society 233rd National Meeting and Exposition in Chicago, Dr. M. Rami Reddy presented, "Use of Computer-Assisted Drug Design in Drug Discovery: Limitations and Advantages of Available Computational Methods."

15 Apr 2007

Boehringer Ingelheim expands license agreement with GeneGo

GeneGo has announced that Boehringer Ingelheim have expanded their licensing agreement with GeneGo which now covers global locations and multiple departments.

11 Apr 2007

Blue-green algae may lead to exciting class of anti-cancer drugs

Combining synthetic chemistry techniques with a knowledge of the properties and actions of enzymes, scientists have been able to produce an exciting class of anti-cancer drugs originally isolated from blue-green algae.

10 Jan 2007

Multivalent effects of RGD peptides obtained by nanoparticle display

While a growing body of literature has shown that nanoparticle targeting can improve drug delivery and tumor imaging, there have been few systematic studies examining the net positive effect of nanoparticle targeting.

23 Oct 2006

Membrane targeted chemotherapy with hybrid liposomes for colon tumor cells leading to apoptosis

One of the unusual properties of tumor cells is that their cell membranes are more fluid and less rigid than those of normal cells.

16 Oct 2006

New method of developing antibiotics

University of Minnesota and University of Michigan researchers have discovered a new method of developing antibiotics, an important step in fighting the growing number of drug-resistant infections.

12 Sep 2006

Genetics is a very strong component of obesity

Nearly 6 percent of morbidly obese children and adults have a genetic defect that keeps them feeling like their stomach is running on empty, no matter how much they have eaten.

6 Aug 2006

Darunavir - first molecule to treat drug-resistant HIV

Doctors have their first FDA-approved tool to treat drug-resistant HIV thanks to a new molecule created by a Purdue University researcher.

2 Aug 2006

Birch bark compound may be potent prostate cancer fighter

A compound found in the bark of the white birch tree - betulonic acid, a derivative of betulinol - may finally have been rendered a water-soluble, bio-available drug, and is already showing the potential to be a possible agent against prostate cancer - in cell culture and in an animal model.

25 Jul 2006