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Study highlights the need to offer genetic testing as standard of care for people with cerebral palsy

A Geisinger meta-analysis of recent research on the genetics of cerebral palsy (CP) provides evidence that genetic testing should be offered as the standard of care for people with the disorder, similar to current recommendations for individuals with other neurodevelopmental disorders (NDD).

6 Mar 2023

New research pinpoints key culprit behind brain cancer metastasis in children

New research pinpoints a key cause of metastasis from an aggressive form of brain cancer in children and provides a potential new therapy for treating these tumors in the future.

6 Mar 2023

Study identifies genetic variants influencing human fertility

Fertility is influenced by mechanisms that influence both reproductive biology and human behavior, according to the largest study to date identifying genetic determinants of the number of children an individual may have.

6 Mar 2023

Erratic sleep patterns may increase blood pressure among teens who have more abdominal fat

Staying awake later into the night and sleeping in on the weekends are hallmarks of adolescent behavior, however, erratic sleep patterns may have consequences for future heart health by increasing blood pressure among teens who have more abdominal fat, according to new research published today in Hypertension, an American Heart Association journal.

6 Mar 2023

LDL cholesterol levels reduced by oral PCSK9 inhibitor in phase 2 trial

MK-0616, an experimental oral proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor, met its primary endpoint and substantially reduced levels of low-density lipoprotein (LDL) cholesterol in people with high cholesterol and/or heart disease related to clogged arteries, in a study being presented at the American College of Cardiology's Annual Scientific Session Together With the World Congress of Cardiology.

6 Mar 2023

Non-critically ill hospitalized Covid-19 patients could substantially benefit from a higher dose of blood-thinners

Giving noncritically ill patients hospitalized for COVID-19 a higher dose of blood-thinning medication than usual did not significantly reduce the combined risk of death from any cause, need for treatment in an intensive-care unit, a confirmed blood clot or a stroke at 30 days, according to the results of the FREEDOM-COVID trial presented at the American College of Cardiology's Annual Scientific Session Together With the World Congress of Cardiology.

6 Mar 2023

Addition of sotatercept to existing therapy shows promise for the treatment of pulmonary arterial hypertension

Patients with pulmonary arterial hypertension (PAH), a severe, progressive condition that affects the heart and lungs, who were treated with the novel first-in-class medication sotatercept on top of existing therapy experienced significant improvements in walking distance via a six-minute walking test—the study's primary endpoint and a validated surrogate for functional improvement and reduced symptom burden.

6 Mar 2023

Vigorous exercise does not increase risk of serious cardiac events in people with hypertrophic cardiomyopathy

People with the inherited heart condition hypertrophic cardiomyopathy (HCM) who exercised vigorously did not have an increased incidence of serious cardiac events during three years of follow-up compared with people who exercised moderately or were inactive, according to a study being presented at the American College of Cardiology's Annual Scientific Session Together With the World Congress of Cardiology.

6 Mar 2023

Clinical trial shows safety and immunogenicity of temperature-stable experimental TB vaccine

A clinical trial testing a freeze-dried, temperature-stable experimental tuberculosis (TB) vaccine in healthy adults found that it was safe and stimulated both antibodies and responses from the cellular arm of the immune system.

6 Mar 2023

Researchers show how CBD can reduce seizures in treatment-resistant forms of childhood epilepsy

Researchers at Aston University have contributed to the discovery of a previously unknown way in which cannabidiol (CBD), a non-psychoactive component of cannabis, can reduce seizures in many treatment-resistant forms of childhood epilepsy.

6 Mar 2023

Study: More than 25% of parents misrepresented their children's COVID-19 status

More than 25% of parents surveyed report that they were less than truthful about their children's COVID-19 status or that they didn't follow the disease's preventive guidelines during the pandemic for their offspring, according to a nationwide study led in part by University of Utah scientists.

6 Mar 2023

Stick-on sensor alerts clinicians about heart failure complications

People with heart failure were 38% less likely to be readmitted to the hospital for heart failure complications within 90 days if they wore a stick-on sensor that alerted their clinician about fluid buildup in the lungs, according to a study presented at the American College of Cardiology's Annual Scientific Session Together With the World Congress of Cardiology.

6 Mar 2023

Fixed-dose combination therapy provides better results than monotherapy for pulmonary hypertension

Patients with pulmonary arterial hypertension (high blood pressure in the arteries that supply the lungs, also called PAH) had approximately double the reduction in pulmonary vascular resistance (PVR) if they took the PAH medications macitentan (10 mg) and tadalafil (40 mg) together in a single tablet rather than either drug alone, according to research being presented at the American College of Cardiology's Annual Scientific Session Together With the World Congress of Cardiology.

6 Mar 2023

Coordinated, multifaceted intervention can improve preventive care for diabetes, heart disease

A multifaceted intervention to improve prescribing practices increased the likelihood that patients with Type 2 diabetes and heart disease would be prescribed three classes of guideline-recommended medications by more than fourfold, according to research being presented at the American College of Cardiology's Annual Scientific Session Together With the World Congress of Cardiology.

6 Mar 2023

What is the impact of oral cannabidiol on simulated driving?

Researchers assessed the impact of cannabidiol on the driving performance of humans.

6 Mar 2023

Struggling to survive, the first rural hospitals line up for new federal lifeline

Just off the historic U.S. Route 66 in eastern New Mexico, a 10-bed hospital has for decades provided emergency care for a steady flow of people injured in car crashes and ranching accidents.

6 Mar 2023

Despite pharma claims, illicit drug shipments to us aren’t full of opioids. It’s generic Viagra.

For years, the FDA has defended its efforts to intercept prescription drugs coming from abroad by mail as necessary to keep out dangerous opioids, including fentanyl.

6 Mar 2023

Women with schizophrenia have threefold risk of interpersonal violence during and after pregnancy

Pregnant and postpartum people with schizophrenia have a more than threefold increase in the risk of an emergency department visit for interpersonal violence, compared with those without schizophrenia, according to a new study in CMAJ.

6 Mar 2023

Even small bouts of exercise protective against heart disease, cancer

In a recent article published in the British Journal of Sports Medicine, researchers explored the relationship between non-occupational physical activity (PA) levels and poor cardiovascular diseases (CVDs) and cancer outcomes, including mortality.

5 Mar 2023

Automated reminders improve guideline-based statin prescribing practices

Patients with cardiovascular disease, such as heart disease, stroke or peripheral arterial disease, were significantly more likely to be prescribed guideline-recommended high-intensity statin therapy if their clinician was sent an automated reminder with information about their cardiovascular disease history, prior statin use and history of statin associated side effects, according to research being presented at the American College of Cardiology's Annual Scientific Session Together With the World Congress of Cardiology.

5 Mar 2023

Medicine News and Research

Study highlights the need to offer genetic testing as standard of care for people with cerebral palsy

New research pinpoints key culprit behind brain cancer metastasis in children

Study identifies genetic variants influencing human fertility

Erratic sleep patterns may increase blood pressure among teens who have more abdominal fat

LDL cholesterol levels reduced by oral PCSK9 inhibitor in phase 2 trial

Non-critically ill hospitalized Covid-19 patients could substantially benefit from a higher dose of blood-thinners

Addition of sotatercept to existing therapy shows promise for the treatment of pulmonary arterial hypertension

Vigorous exercise does not increase risk of serious cardiac events in people with hypertrophic cardiomyopathy

Clinical trial shows safety and immunogenicity of temperature-stable experimental TB vaccine

Researchers show how CBD can reduce seizures in treatment-resistant forms of childhood epilepsy

Study: More than 25% of parents misrepresented their children's COVID-19 status

Stick-on sensor alerts clinicians about heart failure complications

Fixed-dose combination therapy provides better results than monotherapy for pulmonary hypertension

Coordinated, multifaceted intervention can improve preventive care for diabetes, heart disease

What is the impact of oral cannabidiol on simulated driving?

Struggling to survive, the first rural hospitals line up for new federal lifeline

Despite pharma claims, illicit drug shipments to us aren’t full of opioids. It’s generic Viagra.

Women with schizophrenia have threefold risk of interpersonal violence during and after pregnancy

Even small bouts of exercise protective against heart disease, cancer

Automated reminders improve guideline-based statin prescribing practices

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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