Immune System News and Research

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Protein "on/off switch" controls breast cancer spread and immunotherapy response

Despite their promise, immunotherapies fail to treat many cancers, including over 80% of some of the most advanced breast cancers.

20 Dec 2023

Brazilian researchers create cutting-edge nanoparticle weapon against tuberculosis

A low-cost technology involving nanoparticles loaded with antibiotics and other antimicrobial compounds that can be used in multiple attacks on infections by the bacterium responsible for most cases of tuberculosis has been developed by researchers at São Paulo State University (UNESP) in Brazil and is reported in an article published in the journal Carbohydrate Polymers.

20 Dec 2023

OSU study pinpoints early muscle loss mechanism in acute spinal cord injury

Acute spinal cord injury (SCI) patients lose body weight and muscle mass, despite being on a high-calorie diet while in the intensive care unit.

20 Dec 2023

Gamma stimulation may improve memory and cognition in people with Alzheimer's disease

A surprising MIT study published in Nature at the end of 2016 helped to spur interest in the possibility that light flickering at the frequency of a particular gamma-band brain rhythm could produce meaningful therapeutic effects for people with Alzheimer's disease.

20 Dec 2023

New vaccine design targets universal immunity with "chef"-inspired tool

Vaccine development aims at protecting as many people as possible from infections. Short protein fragments of pathogens, so-called epitopes, are seen as a promising new approach for vaccine development.

20 Dec 2023

A new test could save arthritis patients time, money, and pain. But will it be used?

Erinn Maury knew Remicade wasn't the right drug for Patti Schulte, a rheumatoid arthritis patient the physician saw at her Millersville, Maryland, practice. Schulte's swollen, painful joints hadn't responded to Enbrel or Humira, two drugs in the same class.

20 Dec 2023

Embryonic immune sensor could key to creating patient-derived blood stem cells

A microbial sensor that helps identify and fight bacterial infections also plays a key role in the development of blood stem cells, valuable new insight in the effort to create patient-derived blood stem cells that could eliminate the need for bone marrow transplants.

19 Dec 2023

Endometrial cancer rates rising alarmingly, particularly among Black women

The numbers are stark and deeply troubling. Endometrial cancer -; which develops in the lining of the uterus (womb) and is sometimes called uterine cancer -; is on the rise in the U.S. In 1987, there were 35,000 cases annually.

19 Dec 2023

Novel adaptations and functions of human LINE-1 revealed by structural analysis and inhibition

Martin Taylor, MD, PhD, a physician investigator in the Department of Pathology at Massachusetts General Hospital and an instructor in Pathology at Harvard Medical School, is the lead corresponding author of a new study in Nature, Structural Analysis and Inhibition of Human LINE-1 ORF2 Protein Reveals Novel Adaptations and Functions.

19 Dec 2023

NEMO protein's crucial role in Parkinson's defense revealed

Researchers have identified a mechanism that promotes the breakdown of harmful protein deposits. If it malfunctions, it can lead to Parkinson’s disease.

19 Dec 2023

New vaccine could offer affordable hope for millions with high cholesterol

Nearly two in five U.S. adults have high cholesterol, according to the Centers for Disease Control and Prevention (CDC). Untreated, high cholesterol can lead to heart disease and stroke, which are two of the top causes of death in the U.S. Worldwide;, cardiovascular diseases claim nearly 18 million lives every year, according to the World Health Organization.

19 Dec 2023

UCL scientists receive £997,000 from the Type 1 Diabetes Grand Challenge

Scientists at the UCL Institute of Immunity & Transplantation (IIT) are part of a team to receive £997,000 from the Type 1 Diabetes Grand Challenge, a new partnership involving The Steve Morgan Foundation, Diabetes UK and JDRF.

19 Dec 2023

Mice with humanized immune systems test new cancer therapeutic approach that blindfolds immune cells to the body’s self-recognition system

Researchers investigated the anticancer effects of drugs targeting human tumor-associated macrophages (TAMs) in vivo. In humanized murine models, they tested the effectiveness of an antibody to human signal regulatory protein alpha (SIRPα) for cancer immunotherapy.

19 Dec 2023

New study challenges "gold standard" opioid treatment for cancer pain

Researchers examining the data on opioids for pain caused by cancer have found surprisingly large gaps in evidence regarding the true benefits of these medicines for cancer pain.

18 Dec 2023

T-cells step up to offer protection against COVID-19 in B-cell deficient patients

B cell deficiency is a common condition that can result either from immunosuppressant drugs used to treat autoimmune disease or certain cancers -; such as rituximab (RTX) -; or from natural immune deficiency.

18 Dec 2023

Maternal microbiome's pivotal role in shaping fetal and neonatal immune systems during pregnancy

Review in Nature Reviews Gastroenterology and Hepatology explores how the maternal microbiome during pregnancy influences the immune systems of the mother, fetus, and neonate, highlighting its impact on long-term health outcomes and the development of pregnancy complications.

18 Dec 2023

New study casts doubt on effectiveness of opioids for cancer pain

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Immune System News and Research

Protein "on/off switch" controls breast cancer spread and immunotherapy response

Brazilian researchers create cutting-edge nanoparticle weapon against tuberculosis

OSU study pinpoints early muscle loss mechanism in acute spinal cord injury

Gamma stimulation may improve memory and cognition in people with Alzheimer's disease

New vaccine design targets universal immunity with "chef"-inspired tool

A new test could save arthritis patients time, money, and pain. But will it be used?

Embryonic immune sensor could key to creating patient-derived blood stem cells

Endometrial cancer rates rising alarmingly, particularly among Black women

Novel adaptations and functions of human LINE-1 revealed by structural analysis and inhibition

NEMO protein's crucial role in Parkinson's defense revealed

New vaccine could offer affordable hope for millions with high cholesterol

UCL scientists receive £997,000 from the Type 1 Diabetes Grand Challenge

Mice with humanized immune systems test new cancer therapeutic approach that blindfolds immune cells to the body’s self-recognition system

New study challenges "gold standard" opioid treatment for cancer pain

T-cells step up to offer protection against COVID-19 in B-cell deficient patients

Maternal microbiome's pivotal role in shaping fetal and neonatal immune systems during pregnancy

New study casts doubt on effectiveness of opioids for cancer pain

From diabetes drug to anti-inflammation powerhouse: The unexpected evolution of GLP-1

Daily toothbrushing may lower hospital-acquired pneumonia rates

UVA biomedical engineer unveils hidden immune symphony during pregnancy

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