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Gene partnership may be fueling cancer spread in as much as 20% of cancers

A key cancer-causing gene, responsible for up to 20 percent of cancers, may have a weak spot in its armor, according to new research from the Masonic Cancer Center, University of Minnesota.

25 Jun 2014

Study: Cohesin mutations are common in melanoma and bladder cancer

Massive sequencing of cancer genomes brings to light new genes every day that could be involved in the process of tumour formation.

25 Jun 2014

Pew, Stewart Trust announce new scholars program for cancer research

The Pew Charitable Trusts and the Alexander and Margaret Stewart Trust announced the inaugural class of Pew-Stewart Scholars for Cancer Research. Five promising early-career scientists will receive funding for research aimed at finding cures for cancer using approaches that include genetics, pharmacology, and structural biology.

24 Jun 2014

UK scientists unlock untapped genetic information to better understand Intellectual Disability in children

Teams of leading UK scientists have joined forces to unlock an untapped source of genetic information in a bid to better understand and treat children with Intellectual Disability. Experts from Cambridge, Cardiff, and UCL (University College London) will be given unprecedented access to genetic information on intellectual disability from NHS Regional Genetics Centres across the UK as part of a first phase study funded by the Medical Research Council and Medical Research Foundation.

24 Jun 2014

Researchers identify two oncogenes that drive the development of medulloblastoma

A new collaborative study carried out by researchers at Sanford-Burnham Medical Research Institute, UC San Diego, the German Cancer Research Center, the University of Heidelberg (Germany), and 33 other research institutions has identified two oncogenes, called GFI1 and GFI1B, that drive the development of medulloblastoma, the most common malignant brain tumor in children.

23 Jun 2014

Fragile Y hypothesis explains the factors behind chromosome loss

A UT Arlington research team says their study of genetic information from more than 4,000 beetle species has yielded a new theory about why some species lose their Y chromosome and others, such as humans, hang on to it.

18 Jun 2014

Entomologists develop chromosome map to find ways to prevent dengue fever, yellow fever

Virginia Tech entomologists have developed a chromosome map for about half of the genome of the mosquito Aedes agypti, the major carrier of dengue fever and yellow fever.

18 Jun 2014

Genomic study reveals striking contrasts that may aid disease prevention

Virginia Tech entomologists have developed a chromosome map for about half of the genome of the mosquito Aedes agypti, the major carrier of dengue fever and yellow fever.

17 Jun 2014

Modified mosquitoes produce sperm that only creates males

Scientists have modified mosquitoes to produce sperm that will only create males, pioneering a fresh approach to eradicating malaria.

11 Jun 2014

Gene variants that lead to longer telomeres boost brain cancer risk

New genomic research led by UC San Francisco scientists reveals that two common gene variants that lead to longer telomeres, the caps on chromosome ends thought by many scientists to confer health by protecting cells from aging, also significantly increase the risk of developing the deadly brain cancers known as gliomas.

9 Jun 2014

Brain circuit problem may contribute to auditory hallucinations of schizophrenia

St. Jude Children's Research Hospital scientists have identified problems in a connection between brain structures that may predispose individuals to hearing the "voices" that are a common symptom of schizophrenia. The work appears in the June 6 issue of the journal Science.

6 Jun 2014

Scientists reproduce chromosomal modifications in human cells that cause certain cancer

Scientists at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) and the Centro Nacional de Investigaciones Oncol-gicas (CNIO) have succeeded in reproducing, in human cells, the chromosomal translocations that cause two types of cancer: acute myeloid leukemia and Ewing's sarcoma.

5 Jun 2014

Researchers reproduce tumor chromosomal translocations in human cells

Scientists from the Spanish National Cancer Research Centre and the Spanish National Cardiovascular Research Centre have been able to reproduce, for the first time in human cells, chromosomal translocations associated with two types of cancer: acute myeloid leukaemia and Ewing's sarcoma.

4 Jun 2014

Study suggests new targets for treating rare genetic disorder and cancer

The combined action of two enzymes, Srs2 and Exo1, prevents and repairs common genetic mutations in growing yeast cells, according to a new study led by scientists at NYU Langone Medical Center.

2 Jun 2014

Scientists define genetic cause for two types of birth defects in newborn boys

Baylor College of Medicine scientists defined a previously unrecognized genetic cause for two types of birth defects found in newborn boys, described in a report published today in the journal Nature Medicine.

2 Jun 2014

New cancer panel holds promise in detection of previously undetected viral, cancer mutations

Researchers from Sanford Health and Chronix Biomedical today announced that results from a pilot study demonstrating the utility of a new cancer panel to detect previously undetected viral and cancer mutations are to be reported in a poster presentation titled "Detection of novel HPV mutations and chromosomal number imbalance (CNI) in oropharyngeal and laryngeal cancer using next-generation sequencing (NGS)" (Abstract #6072) at the American Society of Clinical Oncology Annual Meeting (ASCO 2014) being held from May 30 through June 3, 2014 in Chicago.

31 May 2014

Scientists collect new data on how "tumor suppressor" gene works

Scientists armed with a supercomputer and a vast trove of newly collected data on the body's most potent "tumor suppressor" gene have created the best map yet of how the gene works, an accomplishment that could lead to new techniques for fighting cancers, which are adept at disabling the gene in order to thrive.

28 May 2014

Study provides insight into genetic causes of cleft lip and cleft palate

Scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, have identified how a specific stretch of DNA controls far-off genes to influence the formation of the face.

28 May 2014

Scientists find interplay between two specific proteins crucial for flawless repair of crosslink damage

Environmental influences such as ionizing radiation, intense heat or various chemical substances damage the DNA constantly.

27 May 2014

Analysis of key cellular protein demonstrates the effectiveness of Taxol anti-cancer drug

A pathway to the design of even more effective versions of the powerful anti-cancer drug Taxol has been opened with the most detailed look ever at the assembly and disassembly of microtubules, tiny fibers of tubulin protein that form the cytoskeletons of living cells and play a crucial role in mitosis.

23 May 2014