Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

EIT Health highlights the urgent need for harnessing data and AI to fight against Alzheimer’s disease

To coincide with World Alzheimer’s Month, EIT Health, an EU-backed network of best-in-class health innovators, has highlighted the urgent need to focus on implementing bolder approaches to the treatment of Alzheimer’s Disease post-pandemic.

20 Sep 2021

Scientists identify new approach to overcome resistance to cancer immunotherapy

Hokkaido University scientists and colleagues in Japan have found a way that could help some patients overcome resistance to immunotherapy treatment for cancer. The approach, proven in mice experiments, was reported in the Journal for Immunotherapy of Cancer.

17 Sep 2021

Study discovers biological mechanism linking long-term arsenic exposure to cancer, diabetes

A University of Arizona Health Sciences study has identified the biological mechanism linking long-term arsenic exposure to diseases such as cancer and Type 2 diabetes.

15 Sep 2021

Study pinpoints a potential pathway for treating epileptic seizures in patients with autism

Autism affects about 2% of children in the United States, and about 30% of these children have seizures. Recent large-scale genetic studies revealed that genetic variants in a sodium channel, called voltage-gated sodium channel Nav1.2, is a leading cause of autism.

15 Sep 2021

Optibrium Releases 3D Ligand-based Design Module for StarDrop Drug Discovery Software

Optibrium Ltd today announced the release of the latest version of StarDrop™, its comprehensive software platform for small molecule design.

From Optibrium Ltd. 9 Sep 2021

Breakthrough discovery could pave the way for new non-opioid painkillers to treat neuropathic pain

Monash University researchers have made a breakthrough discovery that could pave the way for the development of novel non-opioid painkillers to safely and effectively treat neuropathic pain.

8 Sep 2021

Potential pancoronavirus fusion inhibitors that are effective against SARS-CoV-2 variants

A new study successfully identifies a series of inhibitors that possesses pancoronavirus activity against SARS-CoV, SARS-CoV-2, and MERS-CoV.

7 Sep 2021

Impact of colloidal aggregation in COVID-19 drug repurposing screens

A recent study investigated the influence of colloidal aggregation on early drug development in repurposing screens

3 Sep 2021

UTSA receives $3.2 million CPRIT grant for developing new approach to fight against cancer

The University of Texas at San Antonio has been awarded a five-year $3.2 million grant from the Cancer Prevention & Research Institute of Texas.

2 Sep 2021

Baylor researchers use a faster, more cost-effective technology to discover SARS-CoV-2 inhibitor

Much progress has been made on the development of vaccines aiming at triggering human immunity to SARS-CoV-2, the virus that causes COVID-19. In addition, researchers at Baylor College of Medicine are involved in the development of antiviral drugs to treat infected individuals.

1 Sep 2021

Innovative AI and simulation tools used to reveal the inner workings of Sar-CoV-2 virus

Argonne, industry and academia collaborate to bring innovative AI and simulation tools to the COVID-19 battlefront.

1 Sep 2021

Researchers develop adult lung organoids that represent all cell types

Since the COVID-19 pandemic reached the United States in early 2020, scientists have struggled to find laboratory models of SARS-CoV-2 infection, the respiratory virus that causes COVID-19. Animal models fell short; attempts to grow adult human lungs have historically failed because not all of the cell types survived.

31 Aug 2021

Study identifies actionable genes and candidate drugs in biliary tract cancer using a knowledgebase

Oncotarget published "Actionability evaluation of biliary tract cancer by genome transcriptome analysis and Asian cancer knowledgebase" which reported that it is necessary to investigate actionable genes and candidate drugs using a sophisticated knowledgebase and characterize BTCs immunologically for evaluating the actionability of molecular and immune therapies.

31 Aug 2021

New machine learning method enhances computational prediction of RNA structures

Researchers present ARES (Atomic Rotationally Equivariant Scorer) – a machine learning method that significantly improves the computational prediction of RNA structures over previous approaches. Like proteins, RNA molecules twist and fold into intricate three-dimensional shapes that are crucial to their function.

27 Aug 2021

New discovery may lead to more effective treatments for osteoarthritis, other cartilage diseases

New information from a study reported on in STEM CELLS might result in more effective treatments for osteoarthritis and other cartilage diseases, as well as hereditary disorders affecting cartilage development.

25 Aug 2021

Researchers find clues to how lung damage develops in the aftermath of a respiratory infection

The deadliest time in a viral respiratory illness sometimes is actually after the virus is cleared from the body. Destructive processes that are set in motion during an infection crest in the weeks after the virus is defeated, leading to organ damage that can cause chronic illness or even death.

24 Aug 2021

Heidelberg researchers focus on developing drugs against flavi- and coronaviruses

New drugs are intended to help stop viral zoonoses - infections that jump from animals to humans. To study suitable inhibitors, Prof. Dr Christian Klein from the Institute of Pharmacy and Molecular Biotechnology of Heidelberg University is receiving funding in the amount of 450,000 euros from the Volkswagen Foundation.

20 Aug 2021

Drug Discovery News and Research

Further Reading

EIT Health highlights the urgent need for harnessing data and AI to fight against Alzheimer’s disease

Scientists identify new approach to overcome resistance to cancer immunotherapy

Study discovers biological mechanism linking long-term arsenic exposure to cancer, diabetes

Study pinpoints a potential pathway for treating epileptic seizures in patients with autism

Optibrium Releases 3D Ligand-based Design Module for StarDrop Drug Discovery Software

Breakthrough discovery could pave the way for new non-opioid painkillers to treat neuropathic pain

Potential pancoronavirus fusion inhibitors that are effective against SARS-CoV-2 variants

Impact of colloidal aggregation in COVID-19 drug repurposing screens

UTSA receives $3.2 million CPRIT grant for developing new approach to fight against cancer

Baylor researchers use a faster, more cost-effective technology to discover SARS-CoV-2 inhibitor

Innovative AI and simulation tools used to reveal the inner workings of Sar-CoV-2 virus

Researchers develop adult lung organoids that represent all cell types

Study identifies actionable genes and candidate drugs in biliary tract cancer using a knowledgebase

New machine learning method enhances computational prediction of RNA structures

New discovery may lead to more effective treatments for osteoarthritis, other cartilage diseases

Researchers find clues to how lung damage develops in the aftermath of a respiratory infection

Heidelberg researchers focus on developing drugs against flavi- and coronaviruses

Studies shed light on the versatility, precision, and sensitivity of quantitative analytical tools

Scientists identify the main components driving amyloid beta-associated synapse degeneration

ELRIG UK Announces Drug Discovery 2021 Event to Host SLAS’s Innovation AveNEW

eBook: Essential guide to organoids in drug discovery eBook

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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