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Decade-long search in one-celled, fresh water dwelling organism solves puzzle involved in gene regulation

After an intrepid, decade-long search, Johns Hopkins Medicine scientists say they have found a new role for a pair of enzymes that regulate genome function and, when missing or mutated, are linked to diseases such as brain tumors, blood cancers and Kleefstra syndrome -; a rare genetic, neurocognitive disorder.

22 Dec 2022

Phase I clinical trial of PAC-1 in patients with end-stage cancers shows promising results

A phase I clinical trial of PAC-1, a drug that spurs programmed cell death in cancer cells, found only minor side effects in patients with end-stage cancers.

22 Dec 2022

Extracellular vesicles enhance cancer immunotherapy

Nano-sized membrane bubbles known as extracellular vesicles activate the immune system in mice and seem to render their tumors sensitive to a type of immunotherapy drug called a checkpoint inhibitor.

22 Dec 2022

Study could pave the way for new drug to treat hand osteoarthritis

A new study, published in Science Translational Medicine by researchers at the University of Oxford has identified that Talarozole, a drug that is known to increase retinoic acid, was able to prevent osteoarthritis (OA) in disease models.

22 Dec 2022

3D neutron tomography reveals water diffusion across the bone material

What keeps bones able to remodel themselves and stay healthy? A team from Charité Berlin has discovered clues to the key function of non-collagen protein compounds and how they help bone cells react to external load.

22 Dec 2022

‘Caged … for no fault of your own’: Detainees dread covid while awaiting immigration hearings

In October, Yibran Ramirez-Cecena didn't alert the staff at Stewart Detention Center to his cough and runny nose.

22 Dec 2022

ER doctors call private equity staffing practices illegal and seek to ban them

A group of emergency physicians and consumer advocates in multiple states are pushing for stiffer enforcement of decades-old statutes that prohibit the ownership of medical practices by corporations not owned by licensed doctors.

22 Dec 2022

Study helps understand why some people have persistent smell loss after COVID-19 infection

The reason some people fail to recover their sense of smell after COVID-19 is linked to an ongoing immune assault on olfactory nerve cells and an associated decline in the number of those cells, a team of scientists led by Duke Health report.

21 Dec 2022

Sotorasib achieves meaningful anticancer activity in patients with KRAS G12C-mutated metastatic pancreatic cancer

In the Phase I/II CodeBreaK 100 trial, the KRAS G12C inhibitor sotorasib achieved meaningful anticancer activity with an acceptable safety profile in heavily pretreated patients with KRAS G12C-mutated metastatic pancreatic cancer, according to researchers at The University of Texas MD Anderson Cancer Center.

21 Dec 2022

Analysis highlights substantial cost savings by reducing sedation for pediatric brain MRI examinations

Findings from an accepted manuscript published in ARRS' American Journal of Roentgenology have highlighted potentially substantial cost savings by reducing the use of sedation for pediatric brain MRI examinations.

21 Dec 2022

New methods can advance the development of rapid diagnostics for many infectious diseases

Two companion studies report new artificial intelligence approaches for identification of molecular "fingerprints" for specific infections. The methods, used here to derive a fingerprint for COVID-19, can advance the development of rapid diagnostics for many infectious diseases.

21 Dec 2022

Mutations responsible for common inherited heart condition corrected using CRISPR-Cas9 therapy

Using the CRISPR-Cas9 gene editing system, UT Southwestern researchers corrected mutations responsible for a common inherited heart condition called dilated cardiomyopathy (DCM) in human cells and a mouse model of the disease.

21 Dec 2022

UMass Amherst microbiologist receives NIH grant to develop more effective treatments for tuberculosis

A microbiologist at the University of Massachusetts Amherst has received a National Institutes of Health grant to support research aimed ultimately at developing new, more effective treatments for tuberculosis (TB).

21 Dec 2022

Women who have cluster headache are more affected in their daily lives, shows study

Cluster headache, sometimes known as "suicide headache", have been described as a predominantly male disease.

21 Dec 2022

Black patients do not have the same level of access to new, safer heart procedures as white people

Traditional heart surgery, which involves fully opening the chest and cutting through the breastbone, comes with a high risk of complications and a long recovery time.

21 Dec 2022

Study: Long COVID has four major subtypes defined by different clusters of symptoms

The post-COVID syndrome known as long COVID has four major subtypes defined by different clusters of symptoms, according to a study led by researchers at Weill Cornell Medicine.

21 Dec 2022

Research links mutation that causes Huntington's disease to developmental deficits in the brain's oligodendrocyte cells

A research team led by the University of California, Irvine has linked the mutation that causes Huntington's disease to developmental deficits in the brain's oligodendrocyte cells that are caused by changes in metabolism.

21 Dec 2022

Improving neuroplasticity hastens hearing among cochlear implant recipients

Kick-starting the brain's natural ability to adjust to new circumstances, known as neuroplasticity, improves how effectively a cochlear implant can restore hearing loss, a new study in deaf rats shows.

21 Dec 2022

Study provides insights into the coordinated dance of nerve and vascular cells

Nerve cells need a lot of energy and oxygen. They receive both through the blood. This is why nerve tissue is usually crisscrossed by a large number of blood vessels.

21 Dec 2022

Comprehensive lung cell atlas offers insights into an unexpected immune niche in the airways

The most comprehensive lung cell atlas to date, from the Wellcome Sanger Institute and collaborators, has revealed 11 new lung cell types and offers detailed insight into an immune process involved in fighting lung infections.

21 Dec 2022

Medicine News and Research

Decade-long search in one-celled, fresh water dwelling organism solves puzzle involved in gene regulation

Phase I clinical trial of PAC-1 in patients with end-stage cancers shows promising results

Extracellular vesicles enhance cancer immunotherapy

Study could pave the way for new drug to treat hand osteoarthritis

3D neutron tomography reveals water diffusion across the bone material

‘Caged … for no fault of your own’: Detainees dread covid while awaiting immigration hearings

ER doctors call private equity staffing practices illegal and seek to ban them

Study helps understand why some people have persistent smell loss after COVID-19 infection

Sotorasib achieves meaningful anticancer activity in patients with KRAS G12C-mutated metastatic pancreatic cancer

Analysis highlights substantial cost savings by reducing sedation for pediatric brain MRI examinations

New methods can advance the development of rapid diagnostics for many infectious diseases

Mutations responsible for common inherited heart condition corrected using CRISPR-Cas9 therapy

UMass Amherst microbiologist receives NIH grant to develop more effective treatments for tuberculosis

Women who have cluster headache are more affected in their daily lives, shows study

Black patients do not have the same level of access to new, safer heart procedures as white people

Study: Long COVID has four major subtypes defined by different clusters of symptoms

Research links mutation that causes Huntington's disease to developmental deficits in the brain's oligodendrocyte cells

Improving neuroplasticity hastens hearing among cochlear implant recipients

Study provides insights into the coordinated dance of nerve and vascular cells

Comprehensive lung cell atlas offers insights into an unexpected immune niche in the airways

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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