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Study: Purines fend off damage during anesthesia

Anesthesia is quite safe these days. But sometimes putting a patient under to fix one problem, such as heart damage, can harm a different organ, such as a kidney.

19 Dec 2012

EMD Serono's L-BLP25 Phase III NSCLC trial does not meet primary endpoint

EMD Serono, a subsidiary of Merck KGaA, Darmstadt, Germany, announced today that the Phase III STARTa trial of its investigational product L-BLP25 (formerly referred to as Stimuvax) in patients with unresectable, locally advanced stage IIIA or IIIB non-small cell lung cancer (NSCLC) did not meet its primary endpoint to demonstrate a statistically significant improvement in overall survival (OS).

19 Dec 2012

Arthritis, rheumatism and total joint arthroplasty: an interview with Dr Ravi and Dr Hawker

Arthritis translates to “joint inflammation.” The most common form of arthritis is osteoarthritis (OA), which affects 12-15% of North Americans over the age of 60, and will increase in prevalence as our population ages.

19 Dec 2012

Jagaricin and antifungal drugs: an interview with Prof Christian Hertweck

Most people have already experienced a fungal infection (mycosis) of the outer layer of the skin, athlete’s foot or ringworm. Whereas such infections may be cumbersome and often difficult to cure, usually they are not dangerous. However, in cases where a fungus causes a systemic infection, this is, it infects internal organs such as lungs or brain, the infection may turn into a life-threatening disease. Of course, only pathogenic fungi cause problems and the degree of virulence varies.

18 Dec 2012

New once-daily dual bronchodilator effective in COPD

A once-daily, inhaled, fixed-dose dual bronchodilator combination has greater efficacy than twice-daily salmeterol plus fluticasone for the treatment of chronic obstructive pulmonary disease, results of the phase III ILLUMINATE trial show.

18 Dec 2012

Journal of American College Health releases Tobacco Issue

Routledge is pleased to announce the publication of Volume 60, Issue 7, 2012 - the Tobacco Issue -- from Journal of American College Health (JACH).

18 Dec 2012

Scientists decode VEGF/Ang1/Syx pathway that regulates leakiness of blood vessels

A research team led by scientists at Mayo Clinic in Florida have decoded the entire pathway that regulates leakiness of blood vessels — a condition that promotes a wide number of disorders, such as heart disease, cancer growth and spread, inflammation and respiratory distress.

18 Dec 2012

BubR1 and its associated regulators promising targets for aging disorders and cancer

A new series of studies in mouse models by Mayo Clinic researchers uncovered that the aging process is characterized by high rates of whole-chromosome losses and gains in various organs, including heart, muscle, kidney and eye, and demonstrate that reducing these rates slows age-related tissue deterioration and promotes a healthier life span. The findings appear in today's online issue of Nature Cell Biology.

18 Dec 2012

Children in asthma hotspots more likely to experience exercise-induced wheeze

Asthmatic children in New York City neighborhoods with high rates of asthma make many more visits to the emergency room (ER) than those who live in other parts of the city. While socioeconomic factors such as lack of adequate preventive care are part of the equation (high-asthma neighborhoods tend to be lower income), new research points to a possible biological basis for the disparity.

18 Dec 2012

New report provides snapshot of Canada's cancer system

A comprehensive report released today by the Canadian Partnership Against Cancer provides a snapshot of how Canada's cancer system is performing in key areas from prevention through to patient experience and outcomes.

17 Dec 2012

UMCG enrolls and treats first patients in RENEW pivotal trial to evaluate RePneu LVRC

PneumRx, Inc., a leader in interventional pulmonology, announced today that University Medical Center Groningen has enrolled and treated the first patients in the FDA-approved RENEW pivotal trial to evaluate the RePneu Lung Volume Reduction Coil.

17 Dec 2012

GTx achieves enrollment goal for pivotal Phase III clinical studies of enobosarm

GTx, Inc. today announced that it has attained its enrollment goal for both of its pivotal Phase III clinical studies of enobosarm to prevent and treat muscle wasting in non-small cell lung cancer patients.

17 Dec 2012

Immunohistochemistry reliable in identifying ALK rearrangement: Study

Favorable results have led to crizotinib gaining approval for the treatment of advanced stage ALK-positive non-small cell lung cancer (NSCLC) in Japan, the United States, Canada, and several other countries in Europe and Asia.

17 Dec 2012

Strong unadjusted relationship between COPD, pneumonia and lung cancer

Chronic obstructive pulmonary disease (COPD) and lung cancer are two of the most important smoking-related diseases worldwide, with a huge combined mortality bur-den. Many consider the presence of COPD itself to be an independent risk factor for lung cancer. Others argue that smoking contributes to both COPD and lung cancer.

17 Dec 2012

American Thoracic Society, IASLC and ERS propose new sub-classification of lung adenocarcinomas

The International Association for the Study of Lung Cancer (IASLC), the American Thoracic Society (ATS), and the European Respiratory Society (ERS), have proposed a new sub-classification of lung adenocarcinomas.

16 Dec 2012

Endocyte picks Medidata Solutions cloud-based platform to support clinical trials

Biopharmaceutical company Endocyte has selected the Medidata Solutions cloud-based platform to support the execution of multiple ongoing clinical trials focused on the development of targeted therapies for cancer and other serious diseases.

15 Dec 2012

Study describes new, paradoxical characteristics of HER2-negative breast cancer

A multicenter study led by researchers at UC Davis describes new, paradoxical characteristics of the most common type of breast cancer. The findings shed light on how the disease can evade treatment and could improve diagnosis and treatment of breast cancer.

15 Dec 2012

Scientists discover how Yersinia pestis avoids setting off immune system's early infection-alarm

The plague-causing bacteria Yersinia pestis evades detection and establishes a stronghold without setting off the body's early alarms.

14 Dec 2012

Low-wage workers vulnerable to financial hits that can result from on-the-job injuries and illnesses

Low-wage workers, who make up a large and growing share of the U.S. workforce, are especially vulnerable to financial hits that can result from on-the-job injuries and illnesses, according to a policy brief released today by researchers at the George Washington University School of Public Health and Health Services (SPHHS).

14 Dec 2012

Novel antibodies can aid in early diagnosis of Sjogren's Syndrome

Patients suffering from the painful autoimmune disease, Sjogren's Syndrome, will soon be able to be properly diagnosed much earlier, thanks to the discovery of novel antibodies by researchers at the University at Buffalo and Immco Diagnostics, Inc. The breakthrough, described in a paper in the December issue of Clinical Immunology, will allow patients to be treated sooner when they are much more likely to benefit.

14 Dec 2012

Lungs News and Research

Study: Purines fend off damage during anesthesia

EMD Serono's L-BLP25 Phase III NSCLC trial does not meet primary endpoint

Arthritis, rheumatism and total joint arthroplasty: an interview with Dr Ravi and Dr Hawker

Jagaricin and antifungal drugs: an interview with Prof Christian Hertweck

New once-daily dual bronchodilator effective in COPD

Journal of American College Health releases Tobacco Issue

Scientists decode VEGF/Ang1/Syx pathway that regulates leakiness of blood vessels

BubR1 and its associated regulators promising targets for aging disorders and cancer

Children in asthma hotspots more likely to experience exercise-induced wheeze

New report provides snapshot of Canada's cancer system

UMCG enrolls and treats first patients in RENEW pivotal trial to evaluate RePneu LVRC

GTx achieves enrollment goal for pivotal Phase III clinical studies of enobosarm

Immunohistochemistry reliable in identifying ALK rearrangement: Study

Strong unadjusted relationship between COPD, pneumonia and lung cancer

American Thoracic Society, IASLC and ERS propose new sub-classification of lung adenocarcinomas

Endocyte picks Medidata Solutions cloud-based platform to support clinical trials

Study describes new, paradoxical characteristics of HER2-negative breast cancer

Scientists discover how Yersinia pestis avoids setting off immune system's early infection-alarm

Low-wage workers vulnerable to financial hits that can result from on-the-job injuries and illnesses

Novel antibodies can aid in early diagnosis of Sjogren's Syndrome

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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