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Pairing statins with cyclin-dependent kinase inhibitors might effectively treat melanomas

A novel approach to identifying potential anticancer drug combinations revealed that pairing cholesterol-reducing drugs called statins with cyclin-dependent kinase inhibitors might provide an effective approach to treating intractable melanomas driven by mutations in the NRAS and KRAS gene.

14 Dec 2012

Lyncean Technologies announces first sale of Compact Light Source

Palo Alto-based Lyncean Technologies, Inc., today announced its first sale of a Compact Light Source, a miniature synchrotron X-ray source employing state-of-the-art laser-beam and electron-beam technology.

14 Dec 2012

SLU researchers to study physiological and biochemical functions in lupus

Two researchers at Saint Louis University's division of rheumatology in the department of internal medicine have been awarded a $1.8 million NIH grant to study the physiological and biochemical functions in lupus, an autoimmune disease, and develop possible new medications for its treatment.

14 Dec 2012

At-home exercise regimen sufficient to increase cancer patients' mobility and reduce fatigue

It has been known for some time that exercise is important for cancer patients, but few studies have looked at the practicality of exercise programs and whether even a minimal workout can help.

14 Dec 2012

Scientists identify new mutation in a gene that causes Alpha-1 Antitrypsin Deficiency

Scientists have identified a new mutation in the gene that causes the inherited disease known as Alpha-1 Antitrypsin Deficiency (Alpha-1), which affects roughly one in 2,500 people of European descent.

14 Dec 2012

Opioids already in the body can enhance malignant tendencies of human cancer cells

A study led by University of Chicago researcher Patrick A. Singleton, Ph.D. and published in the journal Anesthesiology has shown that, even without the addition of further opioids such as morphine, opioids already in the body can enhance the malignant tendencies of human cancer cells.

13 Dec 2012

Ceramic cookstoves may not reduce risk of pneumonia in young rural Kenyan children

Inexpensive, locally-produced ceramic cookstoves may produce less smoke than traditional indoor 3-stone firepits, but they don't significantly reduce indoor air pollution or the risk of pneumonia in young children, according to results from a small, year-long observational study by researchers working in rural Kenya.

13 Dec 2012

New diagnostic assay for screening ALK fusions in non-small cell lung carcinoma

Approximately one in 20 patients with non-small cell lung carcinoma (NSCLC) has chromosomal aberrations targeting the anaplastic lymphoma kinase (ALK) gene. This has considerable implications for treatment because these patients are highly responsive to ALK-specific kinase inhibitors such as crizotinib.

From NanoString Technologies 13 Dec 2012

Review describes current state of lung cancer care

A review in the December issue of the journal Archives of Pathology & Laboratory Medicine by Paul Bunn Jr, MD, University of Colorado Cancer Center investigator and past president of ASCO, IASLC and AACI describes the current state of lung cancer care.

12 Dec 2012

Spotlight on acute respiratory distress syndrome in low-risk surgery

Postoperative acute respiratory distress syndrome is rare in patients undergoing low-risk surgery, but still carries a very high mortality rate, a large study shows.

12 Dec 2012

Benzodiazepines associated with fatal pneumonia

Benzodiazepines are associated with an increased risk for developing pneumonia, as well as an increased risk for dying from pneumonia, research shows.

12 Dec 2012

Tiotropium benefits patients with chronic obstructive pulmonary disease

In order to widen the narrowed airways in patients with chronic obstructive pulmonary disease (COPD), tiotropium bromide (tiotropium in brief) is one of the drugs available that can be prescribed for inhalation. The German Institute for Quality and Efficiency in Health Care (IQWiG) has examined whether tiotropium offers a perceptible advantage to patients compared to a dummy medication (placebo) and to other COPD drugs.

12 Dec 2012

High-altitude treatment may help severe asthma patients

Individuals with severe refractory asthma may benefit from high-altitude treatment, irrespective of their sensitivity to airborne allergens, suggest findings from a study conducted in the Swiss Alps.

11 Dec 2012

Ultrasonography effective for diagnosing childhood pneumonia

Point-of-care ultrasound scanning can be used to diagnose pneumonia accurately in children and young people, show study findings.

11 Dec 2012

Studies examine current treatment standards for patients with clotting disorders

Studies presented today at the 54th Annual Meeting of the American Society of Hematology (ASH) examine current treatment standards for patients with clotting disorders in an effort to improve outcomes.

11 Dec 2012

New approach can reduce occupational health hazard risks in construction workers

"Some of the most pressing occupational health hazard risks in construction" are associated with masonry operations, asphalt roofing, and welding, wrote Deborah Young-Corbett in an article recently accepted by the Journal of Civil Engineering and Management.

11 Dec 2012

New coronavirus can infect cells from humans and bats alike

The SARS epidemic of 2002-2003 was short-lived, but a novel type of human coronavirus that is alarming public health authorities can infect cells from humans and bats alike, a fact that could make the animals a continuing source of infection, according to a study to be published in in mBio-, the online open-access journal of the American Society for Microbiology, on December 11.

11 Dec 2012

Pfizer's PD0325901 experimental drug blocks untreatable NF1 tumors

Researchers conducting a preclinical study in mice successfully used targeted molecular therapy to block mostly untreatable nerve tumors that develop in people with the genetic disorder Neurofibromatosis 1 (NF1).

11 Dec 2012

GSK, Fred Hutch to develop therapeutics against facioscapulohumeral muscular dystrophy

Fred Hutchinson Cancer Research Center and GlaxoSmithKline PLC (GSK) today announced a partnership to develop therapeutics to treat an inherited form of muscular dystrophy.

11 Dec 2012

Infinity announces new data from IPI-145 Phase 1 trial on advanced hematologic malignancies

Infinity Pharmaceuticals, Inc. today announced new data from its ongoing Phase 1, open-label, dose-escalation trial of IPI-145, the company's potent, oral inhibitor of phosphoinositide-3-kinase (PI3K)-delta and PI3K-gamma, in patients with advanced hematologic malignancies.

11 Dec 2012

Lungs News and Research

Pairing statins with cyclin-dependent kinase inhibitors might effectively treat melanomas

Lyncean Technologies announces first sale of Compact Light Source

SLU researchers to study physiological and biochemical functions in lupus

At-home exercise regimen sufficient to increase cancer patients' mobility and reduce fatigue

Scientists identify new mutation in a gene that causes Alpha-1 Antitrypsin Deficiency

Opioids already in the body can enhance malignant tendencies of human cancer cells

Ceramic cookstoves may not reduce risk of pneumonia in young rural Kenyan children

New diagnostic assay for screening ALK fusions in non-small cell lung carcinoma

Review describes current state of lung cancer care

Spotlight on acute respiratory distress syndrome in low-risk surgery

Benzodiazepines associated with fatal pneumonia

Tiotropium benefits patients with chronic obstructive pulmonary disease

High-altitude treatment may help severe asthma patients

Ultrasonography effective for diagnosing childhood pneumonia

Studies examine current treatment standards for patients with clotting disorders

New approach can reduce occupational health hazard risks in construction workers

New coronavirus can infect cells from humans and bats alike

Pfizer's PD0325901 experimental drug blocks untreatable NF1 tumors

GSK, Fred Hutch to develop therapeutics against facioscapulohumeral muscular dystrophy

Infinity announces new data from IPI-145 Phase 1 trial on advanced hematologic malignancies

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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