Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

New genetically encoded sensor helps detect drugs of abuse

A genetically encoded sensor to detect hallucinogenic compounds has been developed by researchers at the University of California, Davis. Named psychLight, the sensor could be used in discovering new treatments for mental illness, in neuroscience research and to detect drugs of abuse. The work is published April 28 in the journal Cell.

29 Apr 2021

Placental-derived stem cell therapy shows promise to heal intestinal disease in premature babies

An intestinal bowel disease that affects up to 10 percent of premature infants at a very vulnerable and developmentally crucial time can lead to serious infection and death.

27 Apr 2021

Aigenpulse Launches CytoML 5.2: Automated Flow Cytometry With Unbiased Analysis

Aigenpulse has rolled out an update to its CytoML Experiment Suite – its automated, end-to-end, machine learning solution specifically aimed at streamlining and automating cytometry analysis at scale and replacing manual gating processes.

27 Apr 2021

Study may provide a basis for oral insulin development using DNP peptides

Researchers from Kumamoto University, Japan have found that DNP peptide, a small intestine-permeable cyclic peptide originally used as an insulin additive to improve absorption into the small intestinal, lowers blood glucose levels in mice.

26 Apr 2021

Celastrol shows potential anti-SARS-CoV-2 activity

A new study published on the bioRxiv* preprint server focuses on the in-silico predictions to repurpose existing drug compounds, that may have the ability to reverse the SARS-CoV-2 gene expression induced in host cells.

23 Apr 2021

Drug-discovery collaboration finds potential new antimalarial drug candidates

Potential new antimalarial drug candidates are being developed through an extended drug-discovery collaboration between Australian medical research institute WEHI and Janssen Pharmaceutica NV. The collaboration was facilitated by Johnson & Johnson Innovation.

22 Apr 2021

Experts to present latest research on aging and longevity at the 8th Aging Research & Drug Discovery Meeting

Scheibye-Knudsen Lab, University of Copenhagen and Deep Longevity are excited to reveal the speakers for the 8th Aging Research & Drug Discovery Meeting, the largest scientific academic, and industry conference that will transpire on August 31 - September 3, 2021, on-site at the Ceremonial Hall, University of Copenhagen, and online.

22 Apr 2021

Numerous agents with anti-SARS-CoV-2 potential discovered with crystallographic screening

An international team of researchers focused on the macrodomain part of the non-structural protein 3 (Nsp3) gene product that SARS-CoV-2 uses to overturn the host cell’s natural antiviral response. The team provided a template that can help develop novel antivirals that are direct-acting and can combat the current pandemic.

16 Apr 2021

Biognosys announces strategic agreement with Siemens Healthineers

Biognosys announces today that it has established a strategic agreement with Siemens Healthineers through its clinical laboratory in Berkeley, California.

From Biognosys 14 Apr 2021

Study of antiviral nutraceutical phenolics against SARS-CoV-2 main protease

To address this issue, a team of researchers led by Professor Mohamed El Raey of the National Research Centre, Dokki, Cairo, Egypt, looked at phytopharmaceuticals and nutraceuticals as potential antivirals against SARS-CoV-2.

13 Apr 2021

Previously approved drugs starting points for COVID-19 therapeutics

Researchers in the United States have identified several clinically approved compounds that could be repurposed for the treatment and prevention of coronavirus disease 2019 (COVID-19).

11 Apr 2021

Researchers use genetics to identify potential drugs for early management of COVID-19

A new study using human genetics suggests researchers should prioritize clinical trials of drugs that target two proteins to manage COVID-19 in its early stages.

9 Apr 2021

Study reveals molecular mechanisms of drug resistance in Mycobacterium tuberculosis

A consortium of researchers from Russia, Belarus, Japan, Germany and France led by a Skoltech scientist have uncovered the way in which Mycobacterium tuberculosis survives in iron-deficient conditions by utilizing rubredoxin B, a protein from a rubredoxin family that play an important role in adaptation to changing environmental conditions.

9 Apr 2021

New time-lapse system helps measure membrane tension

Ion channels play an indispensable role in cellular physiology, and understanding the physical features that affect ion channel functions is a matter of considerable interest to biologists.

9 Apr 2021

Solvation cages may lead to more efficient operation of high-voltage battery cells

Membranes that allow certain molecules to quickly pass through while blocking others are key enablers for energy technologies from batteries and fuel cells to resource refinement and water purification.

8 Apr 2021

First-of-its-kind study identifies 13 new Alzheimer’s disease genes

In the first study to use whole genome sequencing (WGS) to discover rare genomic variants associated with Alzheimer's disease (AD), researchers have identified 13 such variants (or mutations).

3 Apr 2021

SwiftScale Biologics: Cell-Free Synthesis of Biologics

In this interview, News-Medical talks to David Mace, CEO at SwiftScale Biologics, about the work they do in cell-free synthesis, their partnership with Sartorius and the biologics field as a whole.

From Sartorius 30 Mar 2021

Linear epitope mapping of the SARS-CoV-2 spike protein

The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been the primary target of many drug discovery efforts and is similarly utilized in each of the approved COVID-19 vaccines to elicit the generation of anti-spike protein antibodies, thereby granting immunity.

28 Mar 2021

Boerhavia diffusa possess potential therapeutic properties against COVID-19

Several companies and research groups have been searching for suitably docking ligands that inhibit the function of this protein. In a research paper recently published to the Springer journal VirusDisease by Surya & Praveen (March 6th, 2021) in silico docking simulations towards 3CLpro have been performed, focusing in particular on natural products obtained from the plant Boerhavia diffusa.

28 Mar 2021

Using molecular ‘cookie cutters’ to isolate first ever COVID-19 encounter complex

University of Birmingham researchers are working to isolate and extract the COVID-19 encounter complex in a form that is stable enough for identification of target sites for future anti-viral drugs.

27 Mar 2021

Drug Discovery News and Research

Further Reading

New genetically encoded sensor helps detect drugs of abuse

Placental-derived stem cell therapy shows promise to heal intestinal disease in premature babies

Aigenpulse Launches CytoML 5.2: Automated Flow Cytometry With Unbiased Analysis

Study may provide a basis for oral insulin development using DNP peptides

Celastrol shows potential anti-SARS-CoV-2 activity

Drug-discovery collaboration finds potential new antimalarial drug candidates

Experts to present latest research on aging and longevity at the 8th Aging Research & Drug Discovery Meeting

Numerous agents with anti-SARS-CoV-2 potential discovered with crystallographic screening

Biognosys announces strategic agreement with Siemens Healthineers

Study of antiviral nutraceutical phenolics against SARS-CoV-2 main protease

Previously approved drugs starting points for COVID-19 therapeutics

Researchers use genetics to identify potential drugs for early management of COVID-19

Study reveals molecular mechanisms of drug resistance in Mycobacterium tuberculosis

New time-lapse system helps measure membrane tension

Solvation cages may lead to more efficient operation of high-voltage battery cells

First-of-its-kind study identifies 13 new Alzheimer’s disease genes

SwiftScale Biologics: Cell-Free Synthesis of Biologics

Linear epitope mapping of the SARS-CoV-2 spike protein

Boerhavia diffusa possess potential therapeutic properties against COVID-19

Using molecular ‘cookie cutters’ to isolate first ever COVID-19 encounter complex

eBook: Advancing neurodegenerative research with iPSC-derived microglia models eBook

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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