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Researchers discover new active substance effective against gram negative bacteria

More and more bacterial pathogens of infectious diseases become resistant to customary antibiotics. Typical hospital germs such as Escherichia coli and Klebsiella pneumoniae have become resistant to the most - and in some cases even all - currently available antibiotics. Their additional external membrane makes these bacteria difficult to attack.

21 Nov 2019

Extra DNA scooped up alongside cancer-causing genes helps drive tumor growth

One of the ways a cancer-causing gene works up enough power to turn a normal cell into a cancer cell is by copying itself over and over, like a Xerox machine.

21 Nov 2019

Frailty: An important predictor of worse outcome after traumatic spinal cord injury

A new study has shown that frailty is an important predictor of worse outcome after traumatic spinal cord injury in patients less than 75 years of age. In patients younger than 75 years, frailty was a predictor of adverse events, acute length of stay, and in-hospital mortality, as reported in an article published in Journal of Neurotrauma, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.

21 Nov 2019

Kessler Foundation to study use of minimally invasive treatment for meniscal tears

Kessler Foundation received a $590,000 award from The Geneva Foundation for a three-year study of the use of a an experimental minimally invasive treatment for meniscal tears--the injection of autologous micro-fragmented adipose tissue into the knee joint.

21 Nov 2019

Gene linked to Alzheimer’s plays indirect role in increasing delirium risk

Marked by acute temporary confusion, disorientation and/or agitation, postoperative delirium is the most common post-surgical complication in older adults, striking as many as half of adults older than 65 who undergo high-risk procedures such as cardiac surgery or hip replacements.

21 Nov 2019

Researchers investigate a hospital outbreak in real time using high-resolution technique

On the European Antibiotic Awareness Day, researchers announce the results of a pilot study completed in record time. The initiative opens new perspectives for the control of bacterial infections in Portuguese hospitals.

21 Nov 2019

Graphene-based nanoplatforms for synergistic tumor therapy and bio-imaging

In a paper to be published in the forthcoming issue in NANO, researchers from Harbin Institute of Technology, China have systematically discussed the recent progresses, current challenges and future perspectives of smart graphene-based nanoplatforms for synergistic tumor therapy and bio-imaging.

21 Nov 2019

Sphingolipids associated with heart disease in African Americans with lupus

When it comes to cholesterol, we've come to accept a simple narrative. Our risk of heart disease is lower when we have more "good cholesterol," or high-density lipoproteins (HDL), and less "bad cholesterol," or low-density lipoproteins (LDL) and triglycerides.

21 Nov 2019

Doughnut-shaped circles of ecDNA provide tumor cells with a malignant twist

Deoxyribonucleic acid or DNA encodes information, not only in its sequence but also in its shape.

21 Nov 2019

Researchers develop breakthrough in marine sponge cell culture

Vertebrate, insect, and plant cell lines are important tools for research in many disciplines, including human health, evolutionary and developmental biology, agriculture and toxicology. Cell lines have been established for many organisms, including freshwater and terrestrial invertebrates.

21 Nov 2019

Experimental vaccine elicits antibodies that can neutralize multiple HIV strains

An experimental HIV vaccine developed by scientists at Scripps Research and the nonprofit vaccine research organization IAVI has reached an important milestone by eliciting antibodies that can neutralize a wide variety of HIV strains.

21 Nov 2019

Research team publishes findings from study of TAF1 syndrome

An international, multidisciplinary research team from more than 50 institutions, led by geneticist and psychiatrist Gholson Lyon, MD, PhD, of the New York State Office for People With Developmental Disabilities' Institute for Basic Research in Developmental Disabilities, today announced publication of findings from its study of the rare disease TAF1 syndrome.

21 Nov 2019

Recently discovered protein may play key role in obesity and metabolic disease

With unexpected findings about a protein that's highly expressed in fat tissue, scientists at Scripps Research have opened the door to critical new understandings about obesity and metabolism.

21 Nov 2019

What causes harsher parenting by alcoholic women?

A new study tells us more about what presses the trigger when it comes to harsh parenting by alcohol-dependent mothers.

21 Nov 2019

Machine learning successfully replicates cell architecture

A new study reports the use of machine learning to help form complex cell architectures from pluripotent stem cells.

21 Nov 2019

Researchers identify a promising drug pair to attack deadly childhood brain cancers

Researchers have devised a new plan of attack against a group of deadly childhood brain cancers collectively called diffuse midline gliomas, including diffuse intrinsic pontine glioma, thalamic glioma and spinal cord glioma.

20 Nov 2019

Traditional ways of learning anatomy remain superior than virtual and mixed reality models

A study from McMaster University has shown that traditional ways of learning anatomy remain superior to those that rely on digital media.

20 Nov 2019

Novel microscope optimizes illumination to improve diagnosis

Engineers at Duke University have developed a microscope that adapts its lighting angles, colors and patterns while teaching itself the optimal settings needed to complete a given diagnostic task.

20 Nov 2019

Newly developed ChiTaRS database can collect cases of druggable fusion targets

When sections from two separate genes merge due to various factors, such as translocation or splicing, the hybrid that is formed is called a gene fusion. In recent years, it has been discovered that these fusion events play a vital role in the development of cancers and other complex diseases.

20 Nov 2019

Fosun Pharma, MimiVax to jointly develop and commercialize SurVaxM therapy in U.S.

The inventors of a new and unique cancer immunotherapy developed at Roswell Park Comprehensive Cancer Center have announced a major step forward with that therapy, known as SurVaxM. MimiVax LLC principals Robert Fenstermaker, MD, and Michael Ciesielski, PhD, have announced that the company, spun off from Roswell Park in 2012, has entered into a China-exclusive licensing agreement for SurVaxM with Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd., a wholly-owned subsidiary of Shanghai Fosun Pharmaceutical Co. Ltd. based in Shanghai, China.

20 Nov 2019

Laboratory News and Research

Researchers discover new active substance effective against gram negative bacteria

Extra DNA scooped up alongside cancer-causing genes helps drive tumor growth

Frailty: An important predictor of worse outcome after traumatic spinal cord injury

Kessler Foundation to study use of minimally invasive treatment for meniscal tears

Gene linked to Alzheimer’s plays indirect role in increasing delirium risk

Researchers investigate a hospital outbreak in real time using high-resolution technique

Graphene-based nanoplatforms for synergistic tumor therapy and bio-imaging

Sphingolipids associated with heart disease in African Americans with lupus

Doughnut-shaped circles of ecDNA provide tumor cells with a malignant twist

Researchers develop breakthrough in marine sponge cell culture

Experimental vaccine elicits antibodies that can neutralize multiple HIV strains

Research team publishes findings from study of TAF1 syndrome

Recently discovered protein may play key role in obesity and metabolic disease

What causes harsher parenting by alcoholic women?

Machine learning successfully replicates cell architecture

Researchers identify a promising drug pair to attack deadly childhood brain cancers

Traditional ways of learning anatomy remain superior than virtual and mixed reality models

Novel microscope optimizes illumination to improve diagnosis

Newly developed ChiTaRS database can collect cases of druggable fusion targets

Fosun Pharma, MimiVax to jointly develop and commercialize SurVaxM therapy in U.S.

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