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Risk for childhood cancer moderately increased among adolescents with major birth defects

A multistate study led by researchers at the University of Utah has revealed that the risk for childhood cancer is moderately increased among children and young adolescents with certain types of major birth defects.

12 Aug 2013

Study: Immune-regulating molecules can trigger lymphomas

A small group of immune-regulating molecules, when overproduced even moderately, can trigger the blood cancers known as lymphomas, according to a new study led by scientists from The Scripps Research Institute (TSRI).

9 Aug 2013

Researchers unveil comprehensive portrait of the genome of world's first immortal cell line

A team from the University of Washington has unveiled a comprehensive portrait of the genome of the world's first immortal cell line, known as HeLa. The cell line was derived in 1951 from an aggressive cervical cancer that killed Henrietta Lacks, a 31-year-old African-American tobacco farmer and mother of five - the subject of the 2010 New York Times bestseller, The Immortal Life of Henrietta Lacks.

8 Aug 2013

Research findings may give scientists a way to destroy cancerous cells

Researchers at Warwick Medical School have identified the key role played by a team of proteins in the process of mitosis. Working out how to control them may give scientists a way to destroy cancerous cells.

8 Aug 2013

Cancer-linked mitosis: an interview with Professor Scott Kern, Johns Hopkins University School of Medicine

Mitosis is the process by which a cell gives rise to two daughter cells. It’s the basis behind the growth of the human body, the renewal of the human body as it ages, and unfortunately, the growth of cancers.

7 Aug 2013

Scientists reveal biochemical pathway responsible for manufacturing glycoalkaloids

In 1924, Science magazine reported on a fatal case of potato poisoning: James B. Matheney of Vandalia, Illinois, had gathered about one and a half bushels of tubers, which had turned green due to sunlight exposure.

1 Aug 2013

Researchers identify stem cells in urine can be directed to become multiple cell types

Could harvesting stem cells for therapy one day be as simple as asking patients for a urine sample? Researchers at Wake Forest Baptist Medical Center's Institute for Regenerative Medicine and colleagues have identified stem cells in urine that can be directed to become multiple cell types.

31 Jul 2013

Researchers study how human herpes virus packages genetic information during infection

An international collaboration of researchers including Felicia Goodrum of the University of Arizona's immunobiology department has studied how a human herpes virus carried by the majority of the population packages its genetic information during infection.

31 Jul 2013

Inhalable gene therapy may restore function of crucial enzyme to reverse deadly PAH

The deadly condition known as pulmonary arterial hypertension (PAH), which afflicts up to 150,000 Americans each year, may be reversible by using an inhalable gene therapy, report an international team of researchers led by investigators at the Cardiovascular Research Center at Icahn School of Medicine at Mount Sinai.

31 Jul 2013

Researchers to study knowledge and satisfaction of women who choose DNA prenatal screening test

A recently available DNA-based prenatal blood test used to screen pregnancies for Down syndrome and similar chromosome abnormalities in high-risk women is moving a step closer to use in the general pregnancy population.

From Natera 25 Jul 2013

Study results suggest reexamination of biological, medical importance of X chromosome

Painstaking new analysis of the genetic sequence of the X chromosome—long perceived as the "female" counterpart to the male-associated Y chromosome—reveals that large portions of the X have evolved to play a specialized role in sperm production.

24 Jul 2013

International Consortium receives grant to examine genetic reasons of schizophrenia in deletion syndrome patients

Today, the Royal College of Surgeons in Ireland (RCSI) will host a two day International Brain and Behaviour Consortium meeting on Chromosome 22q11.2 Deletion Syndrome (22q11.2DS).

24 Jul 2013

CLAMP: A newly discovered protein that regulates genes

They say a good man is hard to find. Were it not for a newly discovered protein, the X chromosome of a male fruit fly could never be found by a gene-regulating complex that male flies need to develop and survive. And that case is just one example of what the new finding means. More generally, the research provides biologists with a model of how proteins that govern gene transcription find their targets on chromosomes, a process that's essential to healthy cell function and sometimes implicated in disease.

22 Jul 2013

NKX2-8 mutation in dogs may be a risk factor for human neural tube defects, say researchers

A gene related to neural tube defects in dogs has for the first time been identified by researchers at the University of California, Davis, and University of Iowa.

20 Jul 2013

C. difficile bacteriophage provides new weapon to battle against superbugs

IFR microbiologists are reinvigorating a way of battling C. difficile infections that they hope will help overcome the growing problem of antibiotic resistant superbugs in hospitals.

19 Jul 2013

Discovery provides evidence that genetic defect responsible for Down syndrome can be suppressed

Scientists at the University of Massachusetts Medical School are the first to establish that a naturally occurring X chromosome "off switch" can be rerouted to neutralize the extra chromosome responsible for trisomy 21, also known as Down syndrome, a genetic disorder characterized by cognitive impairment.

18 Jul 2013

Spectrum Pharmaceuticals enters into agreement to acquire Talon Therapeutics

Spectrum Pharmaceuticals, Inc., a biotechnology company with fully-integrated commercial and drug development operations with a primary focus in hematology and oncology, today announced that, through a wholly-owned subsidiary, the company entered into an agreement to acquire Talon Therapeutics, Inc., a biopharmaceutical company based in South San Francisco, California, and expects to complete the acquisition within one day.

17 Jul 2013

Proteins involved in immunity produce cancer-causing DNA mutations, study finds

A set of proteins involved in the body's natural defenses produces a large number of mutations in human DNA, according to a study led by researchers at the National Institutes of Health. The findings suggest that these naturally produced mutations are just as powerful as known cancer-causing agents in producing tumors.

15 Jul 2013

Advanced genetics technologies may help predict patient outcomes in people with ALL

New evidence suggests that using advanced genetics technologies to monitor for remaining cancer cells after treatment may soon become an effective tool to inform treatment decisions and ultimately predict patient outcomes for patients with a particularly aggressive form of acute lymphocytic leukemia (ALL).

10 Jul 2013

Pharmacyclics submits ibrutinib NDA to FDA for two B-cell malignancies

Pharmacyclics, Inc. today announced that it has submitted a New Drug Application to the U.S. Food and Drug Administration for the investigational oral Bruton's tyrosine kinase inhibitor, ibrutinib, for two relapsed/refractory B-cell malignancy indications: mantle cell lymphoma and chronic lymphocytic leukemia/small lymphocytic lymphoma.

10 Jul 2013

X chromosome News and Research

Risk for childhood cancer moderately increased among adolescents with major birth defects

Study: Immune-regulating molecules can trigger lymphomas

Researchers unveil comprehensive portrait of the genome of world's first immortal cell line

Research findings may give scientists a way to destroy cancerous cells

Cancer-linked mitosis: an interview with Professor Scott Kern, Johns Hopkins University School of Medicine

Scientists reveal biochemical pathway responsible for manufacturing glycoalkaloids

Researchers identify stem cells in urine can be directed to become multiple cell types

Researchers study how human herpes virus packages genetic information during infection

Inhalable gene therapy may restore function of crucial enzyme to reverse deadly PAH

Researchers to study knowledge and satisfaction of women who choose DNA prenatal screening test

Study results suggest reexamination of biological, medical importance of X chromosome

International Consortium receives grant to examine genetic reasons of schizophrenia in deletion syndrome patients

CLAMP: A newly discovered protein that regulates genes

NKX2-8 mutation in dogs may be a risk factor for human neural tube defects, say researchers

C. difficile bacteriophage provides new weapon to battle against superbugs

Discovery provides evidence that genetic defect responsible for Down syndrome can be suppressed

Spectrum Pharmaceuticals enters into agreement to acquire Talon Therapeutics

Proteins involved in immunity produce cancer-causing DNA mutations, study finds

Advanced genetics technologies may help predict patient outcomes in people with ALL

Pharmacyclics submits ibrutinib NDA to FDA for two B-cell malignancies

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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