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Fast track approval process for “breakthrough” drugs proposed in the U.S.

Some experimental drugs that show a big effect early in development for treating serious or life-threatening diseases could soon get a faster and cheaper path to U.S. approval, under a proposal likely to become law this year.

10 May 2012

African Americans have more severe complications from scleroderma

African Americans have more severe complications from systemic sclerosis, also known as scleroderma, than Caucasians. Findings published today in, Arthritis & Rheumatism, a journal of the American College of Rheumatology (ACR), show that compared with Caucasians, African-American patients were more likely to have antibodies that increased frequency and severity of pulmonary fibrosis, which is associated with decreased survival.

10 May 2012

Discovery Labs reports data from SURFAXIN preclinical study on RDS

Discovery Laboratories, Inc., a specialty biotechnology company dedicated to advancing a new standard in respiratory critical care, reported that data from a preclinical study of SURFAXIN LS (lyophilized KL4 surfactant) was recently published in the May issue of Pediatric Research.

10 May 2012

Janssen submits XARELTO sNDA with FDA to reduce risk of stent thrombosis in ACS patients

Janssen Research & Development, LLC announced today that it has submitted a supplemental New Drug Application (sNDA) to the U.S. Food and Drug Administration (FDA) seeking approval for the use of XARELTO, an oral anticoagulant, to reduce the risk of stent thrombosis in patients with Acute Coronary Syndrome.

10 May 2012

Botanical formula inhibits breast to lung cancer metastasis in mice

Scientists at Indiana University Health's Cancer Research Laboratory have found that a sophisticated botanical formula slows human breast cancer growth and inhibits breast to lung metastasis in mice. The formula contains extracts from medicinal mushrooms, medicinal herbs and purified nutritional compounds, and showed no toxic side-effects.

9 May 2012

Sildenafil may improve cardiac function in children, young adults with single ventricle defects

Sildenafil, also known as the erectile dysfunction drug Viagra, may give a boost to underdeveloped hearts in children and young adults with congenital heart defects. Researchers from The Children's Hospital of Philadelphia report that sildenafil significantly improved echocardiographic measures of heart function in children and young adult survivors of single ventricle heart disease palliation.

9 May 2012

BioDiem announces new vaccine research collaboration with French-based VIVALIS

Australian vaccine development company BioDiem Ltd (ASX: BDM) today announced that it has begun a research collaboration with France-based VIVALIS (Euronext code: VLS), a biopharmaceutical company with expertise in vaccine production technologies.

9 May 2012

Screening younger men at risk of prostate cancer can reduce metastatic cancer and deaths

Screening younger men and men at risk of prostate cancer can be beneficial in reducing metastatic cancer and deaths and should not be abandoned, states an article published in CMAJ (Canadian Medical Association Journal).

8 May 2012

Research reveals possible strategy to reverse fibrosis in liver and other organs

An international team of scientists, led by researchers at the University of California, San Diego School of Medicine, report that significant numbers of myofibroblasts - cells that produce the fibrous scarring in chronic liver injury - revert to an inactive phenotype as the liver heals. The discovery in mouse models could ultimately help lead to new human therapies for reversing fibrosis in the liver, and in other organs like the lungs and kidneys.

8 May 2012

Many unaware that persistent cough could be a warning for lung cancer

Most people are aware that that a lump in the breast is a warning sign of breast cancer and bleeding could indicate bowel, kidney or bladder cancer. However, only one in ten people knows that a persistent cough could point to lung cancer.

8 May 2012

Campaign announces search for Arizona teens to participate in Addicteen

Arizona's anti-smoking youth campaign, Venomocity Brought to You by Addiction announces a search for Arizona teens to participate in Addicteen, a documentary about addiction. The film will examine activities which teenagers have defined as being addictive including, texting, social media and the use of tobacco. Filmmakers seek to draw out the similarities, differences and impacts of these behaviors on the lives of today's youth.

8 May 2012

T2M cells play a crucial role in treatment-resistant asthma

For most people with asthma, a couple of puffs from an inhaler filled with steroids makes breathing easy. But if their lungs become resistant to the calming effect of that medicine, they live in fear of severe asthma attacks that could send them to the hospital - or worse. Now, new research from the University of Michigan Health System may help explain what's going on in the lungs of these steroid-resistant individuals. The findings could aid the development of new treatment options, and of better ways to identify people at risk of becoming steroid-resistant.

8 May 2012

Zinc oxide could increase risk of skin cancer

As vacationers prepare to spend time outdoors this summer, many of them will pack plenty of sunscreen in hopes it will protect their bodies from overexposure, and possibly from skin cancer. But researchers at Missouri University of Science and Technology are discovering that sunscreen may not be so safe after all.

8 May 2012

Various combinations of biomarkers are required to unequivocally diagnose specific disease

With a range of diseases, doctors need unique features which they can use to unequivocally identify a patient's illness for an appropriate diagnosis. Scientists therefore search for the biomarkers for an illness or a combination of biomarkers, known as biosignatures, which are as easy as possible to measure.

7 May 2012

Vertex reports interim data from VX-809 and KALYDECO combination Phase 2 study for cystic fibrosis

Vertex Pharmaceuticals Incorporated announced today an interim analysis of data from an ongoing Phase 2 study of VX-809 and KALYDECO (ivacaftor) that showed significant improvements in lung function (FEV1) among adults with cystic fibrosis (CF) who have two copies.

7 May 2012

Galleon GAL-021 safe and well-tolerated in Phase I respiratory depression clinical study

Galleon Pharmaceuticals, a leader in the development of novel medicines to treat breathing disorders, today announced that its investigational drug GAL-021 appeared to be safe and well-tolerated and demonstrated dose-proportional pharmacokinetic effects on respiration in a Phase I clinical study of 30 healthy adults.

7 May 2012

Researchers identify new mechanism that causes choroidal neovascularization

Sloppy shipping of a donated human retina to an Indiana University researcher studying a leading cause of vision loss has inadvertently helped uncover a previously undetected mechanism causing the disease. The discovery has led researchers to urge review of how millions of dollars are spent investigating the cause of a type of age-related macular degeneration called choroidal neovascularization.

5 May 2012

PDE4 enzyme regulates division of tumour cells and blood vessel growth in cancer tissue

Lung cancer is the leading cause of cancer death throughout the world. Standard treatment methods do not usually result in long-term recovery. In addition to the proliferation of the tumour cells, the growth of blood vessels controls tumors development. The blood vessel growth is controlled by several signalling molecules. Scientists from the Max Planck Institute for Heart and Lung Research in Bad Nauheim and Justus Liebig University Giessen have discovered a molecule that plays a key role in this process. They succeeded in reducing tumour growth in their experiments by blocking the phosphodiesterase PDE4.

5 May 2012

TCFC completes two in-utero fetal cardiac interventions to treat HLHS

The team at Texas Children's Fetal Center, a national leader for treating fetal anomalies, has successfully completed two in-utero fetal cardiac interventions to treat hypoplastic left heart syndrome (HLHS), a congenital heart defect that is one of the most complex heart defects to treat.

5 May 2012

U.N.-sponsored report finds 1 in 10 infants born prematurely worldwide

Fifteen million infants, or nearly one in 10 worldwide, "are born premature every year, and 1.1 million of those infants die, according to a U.N.-sponsored report released Wednesday," Agence France-Presse reports.

4 May 2012

Lungs News and Research

Fast track approval process for “breakthrough” drugs proposed in the U.S.

African Americans have more severe complications from scleroderma

Discovery Labs reports data from SURFAXIN preclinical study on RDS

Janssen submits XARELTO sNDA with FDA to reduce risk of stent thrombosis in ACS patients

Botanical formula inhibits breast to lung cancer metastasis in mice

Sildenafil may improve cardiac function in children, young adults with single ventricle defects

BioDiem announces new vaccine research collaboration with French-based VIVALIS

Screening younger men at risk of prostate cancer can reduce metastatic cancer and deaths

Research reveals possible strategy to reverse fibrosis in liver and other organs

Many unaware that persistent cough could be a warning for lung cancer

Campaign announces search for Arizona teens to participate in Addicteen

T2M cells play a crucial role in treatment-resistant asthma

Zinc oxide could increase risk of skin cancer

Various combinations of biomarkers are required to unequivocally diagnose specific disease

Vertex reports interim data from VX-809 and KALYDECO combination Phase 2 study for cystic fibrosis

Galleon GAL-021 safe and well-tolerated in Phase I respiratory depression clinical study

Researchers identify new mechanism that causes choroidal neovascularization

PDE4 enzyme regulates division of tumour cells and blood vessel growth in cancer tissue

TCFC completes two in-utero fetal cardiac interventions to treat HLHS

U.N.-sponsored report finds 1 in 10 infants born prematurely worldwide

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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