Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

Major antioxidant in green tea may increase levels of natural anti-cancer protein

An antioxidant found in green tea may increase levels of p53, a natural anti-cancer protein, known as the "guardian of the genome" for its ability to repair DNA damage or destroy cancerous cells.

13 Feb 2021

Study identifies a new factor that increases risk of Alzheimer's disease

People who have a gene variant associated with an increased risk of developing Alzheimer's disease also tend to have changes in the fluid around their brain and spinal cord that are detectable years before symptoms arise, according to new research from Duke Health.

12 Feb 2021

Scientists present new outlook on latest trends in peptide drug discovery and development

Currently there are more than 80 peptide drugs on the global market and about twice as many in clinical development.

10 Feb 2021

Taking Advantage of Measuring Molecular Collisional Cross-Sections in Pharma

News-Medical talks to Mike Greig, Director of Pharma at Bruker, about why measuring collisional cross-sections is beneficial to developing new drugs.

From Bruker Life Sciences Mass Spectrometry 10 Feb 2021

Optibrium Raises Investment to Advance Computer-Aided Drug Discovery

Optibrium™ today announced it has raised significant investment from Kester Capital.

From Optibrium Ltd. 10 Feb 2021

Researchers create bone replicas using a hot nano-chisel

A holy grail for orthopedic research is a method for not only creating artificial bone tissue that precisely matches the real thing, but does so in such microscopic detail that it includes tiny structures potentially important for stem cell differentiation, which is key to bone regeneration.

9 Feb 2021

People with dementia found to have significantly increased risk for COVID-19

A study led by Case Western Reserve University researchers found that patients with dementia were at a significantly increased risk for COVID-19-;and the risk was higher still for African Americans with dementia.

9 Feb 2021

New platform could help advance genomic medicine research, drug discovery

A Cleveland Clinic-led team of researchers has developed a personalized genomic medicine platform that will help advance accelerate genomic medicine research and genome-informed drug discovery, according to new study results published recently in Genome Biology.

8 Feb 2021

New drug candidate to be trialed for most lethal form of brain cancer

A new drug candidate has been discovered by the University of South Australia to treat the most lethal form of brain cancer - glioblastoma - which kills 95 per cent of patients within five years.

4 Feb 2021

NeuroVision Imaging receives ADDF funding to develop biomarker tests for Alzheimer's disease

NeuroVision Imaging Inc., announced today it has received an investment from the Alzheimer's Drug Discovery Foundation to support developing reliable, affordable biomarker tests for Alzheimer's disease and other forms of dementia and neurodegenerative disorders.

3 Feb 2021

Phase 1 clinical trial of novel HIV vaccine approach shows promising results

A phase 1 clinical trial testing a novel vaccine approach to prevent HIV has produced promising results, IAVI and Scripps Research announced today.

3 Feb 2021

Advances in tumor models could expand effectiveness of cancer immunotherapy

Scientists are hoping advances in cancer research could lead to a day when a patient's own immune system could be used to fight and destroy a wide range of tumors.

3 Feb 2021

New process separates beneficial glucocorticoids from unwanted side-effects

A collaboration led by Scripps Research has developed a way to separate the beneficial anti-inflammatory properties of a group of steroids called glucocorticoids from some of their unwanted side-effects, through an optimization process they named "ligand class analysis."

3 Feb 2021

Zinc supplementation bolsters repurposed antivirals against SARS-CoV-2

A new preprint reports the efficacy of two repurposed drugs that could be useful against SARS-CoV-2 when supplemented with zinc.

2 Feb 2021

Harnessing the natural potential of venom with the VOYAGER pipette

Venom, found in numerous species of reptiles, can cause intense pain and even paralysis but, paradoxically, can be used as medication to actually reduce pain.

From INTEGRA Biosciences 1 Feb 2021

New automated measurement system to assess healthy lifespans using nematodes

A research group from Kumamoto University (Japan) has developed an automated measurement system to assess healthy lifespans using nematodes (C. elegans).

27 Jan 2021

Cleveland Clinic receives two grants to study therapeutic potential of anti-cancer drug in Alzheimer's

The National Institute of Aging, part of the National Institutes of Health, and the Alzheimer's Drug Discovery Foundation awarded five-year grants of $3.2 million and $1.4 million, respectively, to scientists from Cleveland Clinic Lou Ruvo Center for Brain Health to study the therapeutic potential of the anti-cancer drug lenalidomide in early-stage Alzheimer's disease, known as mild cognitive impairment.

27 Jan 2021

Study shows how aneuploidy could become a weak point for cancer cells

What makes cancer cells different from ordinary cells in our bodies? Can these differences be used to strike at them and paralyze their activity? This basic question has bothered cancer researchers since the mid-19th century.

27 Jan 2021

New partnership to develop test for predicting disease course in pediatric Crohn's patients

The Crohn's & Colitis Foundation, the leading non-profit organization focused on both research and patient support for inflammatory bowel disease (IBD), has entered into a partnership with LifeArc, an independent medical research charity that advances translation of early science into health care treatments or diagnostics, to potentially develop the first clinical lab test to predict disease course in pediatric patients with Crohn's disease and response to treatment.

25 Jan 2021

Stem cell based cell culture model to recapitulate important aspects of NAFLD

Nonalcoholic fatty liver disease (NAFLD) is a widespread condition in the Western World. Around 30% of the population have lipid droplets stored in their liver which diminish its function in the long term.

25 Jan 2021