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DNA, or deoxyribonucleic acid, is the hereditary material in humans and almost all other organisms. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).

Selfish mutant mtDNA exploits cellular defenses to cause many diseases

Mitochondrial disorders are a chameleon-like set of diseases that take many different forms and vary widely from individual to individual.

12 Jul 2016

Chromatrap reports benefits of ChIP technology in ground breaking research

Chromatrap reports on 3 further customer papers published in different prestigious peer reviewed journals, which cite how its proprietary solid state Chromatin Immunoprecipitation (ChIP) technology has enabled ground breaking research.

From Chromatrap® - Porvair Sciences Ltd 12 Jul 2016

CNIO study shows proinflammatory molecule IL-17A can be key factor in development of NASH and HCC

Non-alcoholic steatohepatitis (NASH) is a serious hepatic condition that precedes hepatocellular carcinoma (HCC) and is currently untreatable.

12 Jul 2016

Metallic molecule offers real-time monitoring of amyloid plaques in patients with Alzheimer's

A metallic molecule being studied at Rice University begins to glow when bound to amyloid protein fibrils of the sort implicated in Alzheimer's disease. When triggered with ultraviolet light, the molecule glows much brighter, which enables real-time monitoring of amyloid fibrils as they aggregate in lab experiments.

11 Jul 2016

Recellularized colon model helps identify cancer driver genes involved in CRC progression

Genetic mutations are a major cause of cancer, and tracking the role of each gene in cancer pathogenesis has long been an important tool in the fight against a disease that is expected to kill more than 1.6 million people this year.

11 Jul 2016

Researchers receive $9 million grant to develop novel platform to quickly identify new antibiotics

In September 2014, President Obama issued an executive order for "Combating Antibiotic- Resistant Bacteria." Why the urgency? The Centers for Disease Control and Prevention, the order noted, "estimates that annually at least 2 million illnesses and 23,000 deaths are caused by antibiotic- resistant bacteria in the United States alone."

11 Jul 2016

JAX researchers find precise, reliable way to identify leukemia cells of origin

Every cancer starts with a single cell, and Jackson Laboratory researchers have found a precise and reliable way -- whole-genome profiling of open chromatin -- to identify the kind of cell that leads to a given case of leukemia, a valuable key to cancer prognosis and outcome.

11 Jul 2016

NIH selects VUMC to play foundational role in PMI Cohort Program

Vanderbilt University Medical Center has been chosen by the National Institutes of Health to be the Data and Research Support Center for the Precision Medicine Initiative Cohort Program, a landmark study of genetic, environmental and lifestyle factors affecting the health of a million or more people, federal officials have announced.

11 Jul 2016

Mussels inspire scientists to attach biologically active molecule to titanium surface

Titanium is used medically in applications such as artificial joints and dental implants. While it is strong and is not harmful to tissues, the metal lacks some of the beneficial biological properties of natural tissues such as bones and natural teeth.

11 Jul 2016

Scientists detect first cell from which tumour grows in skin cancers

Scientists have identified for the first time the 'cell of origin' - in other words, the first cell from which the cancer grows - in basal cell carcinoma, the most common form of skin cancer, and followed the chain of events that lead to the growth of these invasive tumours.

11 Jul 2016

Scientists identify epigenetic alterations involved in autoinflammatory diseases

Researchers from the Chromatin and Disease group of the Bellvitge Biomedical Research Institute, led by Dr. Esteban Ballestar, have identified for the first time epigenetic alterations in autoinflammatory diseases, particularly in cryopyrin-associated periodic syndromes (CAPS).

8 Jul 2016

New diagnostic blood test may offer hope for transplant recipients through analysis of cfDNA

When cells die, whether through apoptosis or necrosis, the DNA and other molecules found in those cells don't just disappear. They wind up in the blood stream, where degraded bits and pieces can be extracted.

8 Jul 2016

Moffitt researchers discover novel way to control SETDB1 protein upregulated in cancer

Cancer is a group of more than 100 different diseases. All are driven by cells and genes that escape the normal process of division and begin their own plan to replicate in the body.

8 Jul 2016

Research opens up new ways to detect, inhibit cancer spread

Clusters of circulating cells commonly found in the blood of cancer patients have long been the subject of research on cancer. These clusters have been regarded for more than 50 years as malignant cells that have broken off from the primary tumor, spreading cancer to other parts of the body.

8 Jul 2016

Molecule thought to indicate good cancer prognosis can have dark side, research shows

A molecule which, for the last 20 years has been believed to be an indicator of good prognosis in tumours has been shown to have a dark side by new research from The Universities of Manchester, Athens and collaborators, recently published in Nature Cell Biology.

8 Jul 2016

Microbes detected in Boston subway system have low pathogenic potential, study shows

Boston's subway system, known as the T, might be just as bacteria-laden as you'd expect but organisms found there are largely from normal human skin and incapable of causing disease, according to a study published June 28 in mSystems, an open access journal of the American Society for Microbiology.

8 Jul 2016

Scientists identify set of genes that could predict clinical outcomes in patients with FLT3-ITD AML

Researchers from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore have identified a set of genes, including DNMT3A, that could potentially be used to predict clinical outcomes of patients who suffer from a type of Acute Myeloid Leukemia (AML) associated with an FLT3 internal tandem duplication (FLT3-ITD) mutation.

8 Jul 2016

Germline genetic testing necessary for men with metastatic prostate cancer

Men with metastatic prostate cancer should be considered for germline genetic testing of DNA repair genes, regardless of age or family history, according to a team of researchers from Memorial Sloan Kettering Cancer Center, Fred Hutchinson Cancer Research Center, Dana-Farber Cancer Institute, University of Washington School of Medicine, University of Michigan, and the Institute of Cancer Research Royal Marsden Hospital.

8 Jul 2016

Researchers develop DNA-based nanomachine to detect variety of substances

Researchers at McMaster University have established a way to harness DNA as the engine of a microscopic "machine" they can turn on to detect trace amounts of substances that range from viruses and bacteria to cocaine and metals.

8 Jul 2016

Researchers discover mechanism of gene silencing in hormone-dependent breast cancer cells

Sometimes, the silencing of a gene is as important as its activation. Nonetheless, up to now, most studies on hormone-mediated gene regulation have focused on researching the factors that influence the activation of certain genes. Little attention has been paid to gene silencing.

8 Jul 2016

DNA News and Research

Further Reading

Selfish mutant mtDNA exploits cellular defenses to cause many diseases

Chromatrap reports benefits of ChIP technology in ground breaking research

CNIO study shows proinflammatory molecule IL-17A can be key factor in development of NASH and HCC

Metallic molecule offers real-time monitoring of amyloid plaques in patients with Alzheimer's

Recellularized colon model helps identify cancer driver genes involved in CRC progression

Researchers receive $9 million grant to develop novel platform to quickly identify new antibiotics

JAX researchers find precise, reliable way to identify leukemia cells of origin

NIH selects VUMC to play foundational role in PMI Cohort Program

Mussels inspire scientists to attach biologically active molecule to titanium surface

Scientists detect first cell from which tumour grows in skin cancers

Scientists identify epigenetic alterations involved in autoinflammatory diseases

New diagnostic blood test may offer hope for transplant recipients through analysis of cfDNA

Moffitt researchers discover novel way to control SETDB1 protein upregulated in cancer

Research opens up new ways to detect, inhibit cancer spread

Molecule thought to indicate good cancer prognosis can have dark side, research shows

Microbes detected in Boston subway system have low pathogenic potential, study shows

Scientists identify set of genes that could predict clinical outcomes in patients with FLT3-ITD AML

Germline genetic testing necessary for men with metastatic prostate cancer

Researchers develop DNA-based nanomachine to detect variety of substances

Researchers discover mechanism of gene silencing in hormone-dependent breast cancer cells

eBook: A guide to RNA sequencing eBook

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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