Bioinformatics News and Research

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Bioinformatics is the application of information techniques for the storage, retrieval, and analysis of large quantities of biological data.

Study shows how glucocorticoid hormones control sugar and fat levels over the course of 24 hours

For the first time, a study led by researchers at Helmholtz Zentrum München and the German Center for Diabetes Research shows how glucocorticoid hormones, such as cortisol, control sugar and fat levels differently during day and night, feeding and fasting, rest and activity, over the course of 24 hours.

10 Nov 2019

San Diego-based Predictive Science releases first forecast for influenza season

San Diego-based Predictive Science, Inc. this week released their first forecast for the 2019-2020 influenza season, which typically runs from November through March.

4 Nov 2019

New, open-source database improves genomics research collaboration

Sharing datasets that reveal the function of genomic variants in health and disease has become easier, with the launch of a new, open-source database developed by Australian and North American researchers.

3 Nov 2019

Discovery of human cell signaling systems using bioinformatics

There are many and various receptors on the surface of each human cell, which bind to specific molecules called ligands, to set off signals that modulate cell activity accordingly. These pathways are exploited by therapeutic drugs. In fact, one in three drugs makes use of receptors belonging to a single very large family – the GPCR (G protein receptor coupled receptor) family.

1 Nov 2019

Study identifies a kinase as potential target to treat heart failure

An unexplored kinase in heart muscle cells may be a good target to treat heart failure, a disease that is only incrementally delayed by existing therapies.

31 Oct 2019

New software helps assess interoperability and reusability of biomedical digital research objects

Mount Sinai investigators, together with an international consortium of colleagues, have developed a new toolbox to allow scientists to assess how easily the digital objects they generate as a result of their research projects can be used by other research teams.

31 Oct 2019

Polygenic scoring system shows promise to predict depression risk and resilience under stress

Depression doesn't come from one gene, one life event, or one personality trait. That's what makes it so hard to predict, prevent or treat effectively.

29 Oct 2019

New method can indicate prognosis of aggressive breast cancer

Aggressive forms of breast cancer often manipulate the immune response in their favor. This manipulation is revealed in humans by the same immunological "signature" as in mice. This is shown by a study carried out by scientists from the University of Bonn together with Dutch colleagues.

29 Oct 2019

Researchers develop new genomic analysis method for identifying Yersinia strains

The Yersinia genus covers a vast range of bacteria that are distinguished by criteria such as whether or not they are able to cause disease (their pathogenicity).

29 Oct 2019

Researchers reconstruct the evolutionary history of metabolism

By analyzing how metabolic enzymes are built and organized, researchers have reconstructed the evolutionary history of metabolism. Their study shows how metabolic networks - which drive every cellular process from protein building to DNA repair - became less random, more modular and more hierarchical over time, the researchers say.

29 Oct 2019

Dartmouth scientist awarded grant to build new AI technologies for lung cancer management

Lung cancer is the second most common type of cancer and leading cause of cancer death in men and women, with non-small cell lung cancer (NSCLC) accounting for up to 90% of cases. Somatic mutations heavily impact the sensitivity of NSCLC patients to various drug treatments, and are critical for choosing the most effective targeted therapies for this cancer.

23 Oct 2019

New study on zebrafish may have possible relevance for heart regeneration in humans

In mammals, including humans, the heart muscle has a very limited capacity to recover after injury. After an acute myocardial infarction, millions of cardiac muscle cells, named cardiomyocytes, die, and are replaced by a scar.

23 Oct 2019

Researchers identify cancer symptom clusters using EHR data

Patients with chronic diseases such as breast cancer or colorectal cancer often experience fatigue, pain, depression and other symptoms which can lead to distress and functional impairment if left untreated.

22 Oct 2019

Antibiotic treatment can cause transient and long-term disruption of gut microbes

Trillions of microbes in the intestine aid human health, including digestion of breast milk, breaking down fiber and helping control the immune system.

22 Oct 2019

Dual action of genes and RNA influences aggressive triple-negative breast cancer

Women with an aggressive, less-common type of breast cancer, known as triple-negative, versus a more common form of the disease, could be differentiated from each other by a panel of 17 small RNA molecules that are directly influenced by genetic alterations typically found in cancer cells.

22 Oct 2019

Patterns unique to the striatum observed in people with Huntington's disease

The part of the brain that selectively degenerates in people with Huntington's disease (HD), called the striatum, is almost entirely destroyed in the late stages of the disease. Brain samples from mutant HD gene positive individuals who had not yet developed symptoms by time of death are extremely rare. As a consequence, very little is known about the active disease process that causes the devastating symptoms of HD.

21 Oct 2019

Study shows link between high-fat diet and earlier appearance of Alzheimer's markers in the brain

Once it begins, Alzheimer's disease progresses systematically and aggressively, attacking victims on multiple fronts. But scientists studying the disease operate the same way - like Kent State University's own Gemma Casadesus Smith, Ph.D.

17 Oct 2019

NIH awards new contract to integrate pathogen and vector genomics database

A team led by scientists at the University of Pennsylvania and University of Georgia provides thousands of researchers around the world with access to the Eukaryotic Pathogen Genomics Database (EuPathDB.org), a collection of resources for analyzing large-scale datasets associated with microbial pathogens.

16 Oct 2019

Insilico Medicine presents experimentally validated model for drug discovery at NeurIPS 2019

Insilico Medicine, a biotechnology company developing an end-to-end drug discovery pipeline utilizing next-generation artificial intelligence, is proud to present its paper "A Prior of a Googol Gaussians: a Tensor Ring Induced Prior for Generative Models" at the 33rd Conference on Neural Information Processing Systems (NeurIPS).

16 Oct 2019

Researchers reveal mechanism involved in altering DNA methylation in cancer

Understanding the mechanisms that mediate widespread DNA damage in the cancer genome is of great interest to cancer physicians and scientists because it may lead to improved treatments and diagnosis. In this study, a multi-institutional team led by researchers at Baylor College of Medicine has brought attention to genomic structural variation as a previously unappreciated mechanism involved in altering DNA methylation, a form of gene control, in human cancers.

15 Oct 2019

Bioinformatics News and Research

Further Reading

Study shows how glucocorticoid hormones control sugar and fat levels over the course of 24 hours

San Diego-based Predictive Science releases first forecast for influenza season

New, open-source database improves genomics research collaboration

Discovery of human cell signaling systems using bioinformatics

Study identifies a kinase as potential target to treat heart failure

New software helps assess interoperability and reusability of biomedical digital research objects

Polygenic scoring system shows promise to predict depression risk and resilience under stress

New method can indicate prognosis of aggressive breast cancer

Researchers develop new genomic analysis method for identifying Yersinia strains

Researchers reconstruct the evolutionary history of metabolism

Dartmouth scientist awarded grant to build new AI technologies for lung cancer management

New study on zebrafish may have possible relevance for heart regeneration in humans

Researchers identify cancer symptom clusters using EHR data

Antibiotic treatment can cause transient and long-term disruption of gut microbes

Dual action of genes and RNA influences aggressive triple-negative breast cancer

Patterns unique to the striatum observed in people with Huntington's disease

Study shows link between high-fat diet and earlier appearance of Alzheimer's markers in the brain

NIH awards new contract to integrate pathogen and vector genomics database

Insilico Medicine presents experimentally validated model for drug discovery at NeurIPS 2019

Researchers reveal mechanism involved in altering DNA methylation in cancer

eBook: A guide to RNA sequencing eBook

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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