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New approach could improve immune checkpoint inhibitor response in MTAP-deficient tumors

Loss of the "housekeeping" gene methylthioadenosine phosphorylase, or MTAP, is a common event in cancer.

28 Sep 2023

SARS-CoV-2 virus can trigger dangerous immune response in artery-clogging plaques

In some patients, infection with the pandemic virus SARS-CoV-2 can trigger a dangerous immune response in hardened fatty deposits (plaques) lining the heart's largest blood vessels, a new study shows.

28 Sep 2023

SARS-CoV-2 infects coronary vessels, inducing plaque inflammation

SARS-CoV-2, the virus that causes COVID-19, can directly infect the arteries of the heart and cause the fatty plaque inside arteries to become highly inflamed, increasing the risk of heart attack and stroke, according to a study funded by the National Institutes of Health.

28 Sep 2023

Study uncovers previously unknown compensatory mechanism in liver disease

A team of researchers has uncovered a previously unknown compensatory mechanism found in liver disease.

28 Sep 2023

Internet-delivered CBT may help reduce depressive symptoms in patients with multiple sclerosis

Major depressive disorder affects up to 50% of all individuals with multiple sclerosis (MS) at some point during their lifetime and can lead to lower quality of life, greater disease progression and higher mortality.

27 Sep 2023

HMS researcher to lead $104 million effort to study bacteria and antibiotic resistance

Harvard Medical School researcher Johan Paulsson will lead a multi-institutional $104 million effort to study bacteria and antibiotic resistance, the U.S. Department of Health and Human Services announced today.

27 Sep 2023

Study details the key role played by neutrophils in ensuring survival of brain cancers

A Ludwig Cancer Research study has for the first time exhaustively analyzed immune cells known as neutrophils that reside in brain tumors, including gliomas, which develop in the brain itself, and cancers that spread there from the lung, breast and skin.

27 Sep 2023

Mutations on a key SARS-CoV-2 viral protein linked to extreme immune responses

Mutations on a key SARS-CoV-2 viral protein are linked to extreme immune responses and could offer a novel vaccine target.

27 Sep 2023

As covid infections rise, nursing homes are still waiting for vaccines

"Covid is not pretty in a nursing home," said Deb Wityk, a 70-year-old retired massage therapist who lives in one called Spurgeon Manor, in rural Iowa. She twice contracted the disease and is eager to get the newly approved vaccine because she has chronic lymphocytic leukemia, which weakens her immune system.

27 Sep 2023

Promising potential of probiotics and their byproducts for targeting antibiotic-resistant bacteria

The use of probiotics and antimicrobial peptides (AMPs) against multi-drug-resistant (MDR) bacteria.

27 Sep 2023

Senescent macrophages in the lung promote tumor growth, study finds

Macrophages are a type of white blood cell that are among the body's first line of defense against infection. In addition to killing harmful microorganisms, macrophages typically can initiate a response against tumors.

25 Sep 2023

Radiation therapy combined with two types of immunotherapy could be effective against cold tumors

Researchers at Weill Cornell Medicine have discovered that radiation therapy combined with two types of immunotherapy-;one that boosts T cells, and another that boosts dendritic cells-;can control tumors in preclinical models of triple negative breast cancer, a cancer type that's typically resistant to immunotherapy alone.

25 Sep 2023

Engineered mice reveal how Omicron subvariant BA.5 is more virulent

New research used engineered mice to compare SARS-COV-2 omicron subvariants and found one of them – BA.5 – was more virulent likely due to its ability to rapidly replicate early during infection.

25 Sep 2023

COVID drug molnupiravir appears to be driving SARS-CoV-2 to mutate and evolve

Molnupiravir, an antiviral drug used to treat patients with COVID-19, appears to be driving SARS-CoV-2 to mutate and evolve, with some of these new viruses being transmitted onwards, a new study has shown. It is not clear, however, whether these mutated viruses pose an increased risk to patients or are able to evade the vaccine.

25 Sep 2023

Future-proof vaccine candidate protects against wide range of coronaviruses

Studies of a 'future-proof' vaccine candidate have shown that just one antigen can be modified to provide a broadly protective immune response in animals.

25 Sep 2023

Long COVID patients exhibit different immune and hormonal responses to the virus, study shows

People who have experienced brain fog, confusion, pain, and extreme fatigue for months or longer after being infected with the COVID-19 virus exhibit different immune and hormonal responses to the virus than those not diagnosed with long COVID, according to a new study by researchers at Yale School of Medicine and Icahn School of Medicine at Mount Sinai.

25 Sep 2023

Killer T cells in older adults resemble those found in newborns, but fall short in virus detection

A world-first discovery has revealed special immune cells called 'killer T cells' in older adults, directed against influenza viruses, closely resemble those found in newborns and children, but struggle to recognize infected cells – a finding that unlocks the potential for the development of better vaccines and therapies tailored to different age groups.

25 Sep 2023

UMMC transplant team performs second pig heart transplant on patient with end-stage heart disease

After world's first successful transplant in 2022, also performed at the University of Maryland Medical Center (UMMC), this groundbreaking transplant team performed second pig heart transplant on patient deemed ineligible for traditional heart transplant.

25 Sep 2023

Scientists decode the marker protein that can be used to ‘‘see’’ neuroinflammation

Inflammation is the sign that our body is defending itself against an aggression. But when this response escalates, for example in the brain, it can lead to serious neurological or psychiatric diseases.

25 Sep 2023

The power of nanobodies: How they impact COVID-19 immune response

The structures of 340 antibodies (Abs) and 83 nanobodies.

25 Sep 2023

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Immune System News and Research

New approach could improve immune checkpoint inhibitor response in MTAP-deficient tumors

SARS-CoV-2 virus can trigger dangerous immune response in artery-clogging plaques

SARS-CoV-2 infects coronary vessels, inducing plaque inflammation

Study uncovers previously unknown compensatory mechanism in liver disease

Internet-delivered CBT may help reduce depressive symptoms in patients with multiple sclerosis

HMS researcher to lead $104 million effort to study bacteria and antibiotic resistance

Study details the key role played by neutrophils in ensuring survival of brain cancers

Mutations on a key SARS-CoV-2 viral protein linked to extreme immune responses

As covid infections rise, nursing homes are still waiting for vaccines

Promising potential of probiotics and their byproducts for targeting antibiotic-resistant bacteria

Senescent macrophages in the lung promote tumor growth, study finds

Radiation therapy combined with two types of immunotherapy could be effective against cold tumors

Engineered mice reveal how Omicron subvariant BA.5 is more virulent

COVID drug molnupiravir appears to be driving SARS-CoV-2 to mutate and evolve

Future-proof vaccine candidate protects against wide range of coronaviruses

Long COVID patients exhibit different immune and hormonal responses to the virus, study shows

Killer T cells in older adults resemble those found in newborns, but fall short in virus detection

UMMC transplant team performs second pig heart transplant on patient with end-stage heart disease

Scientists decode the marker protein that can be used to ‘‘see’’ neuroinflammation

The power of nanobodies: How they impact COVID-19 immune response

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