Transplant News and Research

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First general selection criteria for lung transplantation in Covid-19 patients

In May 2020, a team led by thoracic surgeon Konrad Hoetzenecker of the Department of Surgery of MedUni Vienna and Vienna General Hospital performed a lung transplant on a 44-year-old patient who had been seriously ill with Covid-19, making her the first patient in Europe to receive a lung transplant for this indication.

2 Apr 2021

Researchers offer large-scale screening of potential broad-spectrum SARS-CoV-2 antivirals

A new study describes the identification of new compounds from a library, with inhibitory activity against several coronaviruses. This study shows the utility of this method, besides identifying compounds that not only inhibit viral shedding in SARS-CoV-2 cultures, but have an immunomodulatory effect that may be useful in mitigating the damaging cytokine storm typical of severe or critical COVID-19.

2 Apr 2021

Unique approach to heart-liver transplant offers new hope for highly sensitized patients

All too often, patients with high levels of antibodies face major challenges getting a transplant. These highly sensitized patients have a much higher risk of death while waiting for suitable organs they are less likely to reject.

1 Apr 2021

Stem cell transplants offer long-term benefits for pediatric cancer patients receiving immunotherapy

Children and young adults who receive CAR T-cell therapy for the most common childhood cancer - acute lymphoblastic leukemia - suffer remarkably fewer relapses and are far more likely to survive when the treatment is paired with a subsequent stem cell transplant, a new study finds.

1 Apr 2021

Infliximab may hinder the effectiveness of some COVID-19 vaccines

A new study reports reduced vaccine efficacy following the use of a single COVID-19 vaccine dose in people who are on the immunosuppressive monoclonal antibody Infliximab.

31 Mar 2021

Scientists launch clinical trial of CRISPR gene correction therapy in patients with sickle cell disease

Scientists at UC San Francisco, UC Berkeley and UCLA have received U.S. Food and Drug Administration approval to jointly launch an early phase, first-in-human clinical trial of a CRISPR gene correction therapy in patients with sickle cell disease using the patient's own blood-forming stem cells.

30 Mar 2021

Research consortium identifies cell stress mechanisms for chronic inflammatory liver disease

Primary sclerosing cholangitis (PSC) is a rare, chronic, inflammatory disease of the bile ducts and is difficult to treat, since its causes have not yet been adequately researched.

30 Mar 2021

Simple, no-cost intervention can increase the number of prospective donors

Researchers from Queens University, Boston University, University of Toronto, University of Rochester, and Treasury Board Secretariat, Government of Canada published a new paper in the Journal of Marketing that tests a simple, no-cost intervention that can double registration rates, thus helping communities gradually increase the number of prospective donors.

26 Mar 2021

Moffitt researchers use mathematical modeling to help explain outcomes of CAR T-cell therapy

Chimeric antigen receptor T-cell therapy, or CAR T, is a relatively new type of therapy approved to treat several types of aggressive B cell leukemias and lymphomas.

25 Mar 2021

Blood type-incompatible pediatric heart transplant shown to be as effective as the traditional approach

A pediatric heart transplant procedure pioneered by Canadian doctors--once deemed impossible--has been shown to be at least as effective as the traditional approach, according to newly published research in The Lancet Child & Adolescent Health.

25 Mar 2021

COVID vaccines have only 17% detectable antibodies against SARS-CoV-2 virus

When clinical trials were conducted to determine the immunogenicity -- the ability to elicit an immune response -- for the first two vaccines marshaled against SARS-CoV-2the virus that causes COVID-19, one group was not among those included: people who have received solid organ transplants and others (such as those with autoimmune disorders) who are immunocompromised.

25 Mar 2021

Researchers develop innovative biosensor that can detect and quantitate SARS-CoV-2 infection

Researchers have generated protease-activatable fluorescent and luminescent biosensors for SARS-CoV-2 MPro (main protease) and PLPro (papain-like protease) activity, one based on “flip” GFP (FlipGFP), and the other based on circularly permuted firefly luciferase (FFluc).

24 Mar 2021

New technique traces genetic and epigenetic origins of DNA to reveal hidden cancers

A new technique that can trace which tissues and organs the DNA in our blood comes from has been reported today in the open-access eLife journal.

24 Mar 2021

Study finds two drugs capable of slowing bone marrow cancer progression

Primary myelofibrosis (PMF), a relatively rare but painful type of bone marrow cancer, disrupts the body's normal production of blood cells by causing extensive scarring in the bone marrow.

22 Mar 2021

Virtual reality experiences can be used to train professionals in organ donation and transplants

The Donation and Transplantation Institute and Immersium Studio, a UOC spin-off, have developed virtual reality experiences that can be used to train health professionals in the area of organ and tissue donation and transplantation.

18 Mar 2021

Progesterone therapy may improve clinical outcomes for male COVID-19 patients

COVID-19 disproportionately affects men compared with women, raising the possibility that a hormone like progesterone may improve clinical outcomes for certain hospitalized men with the disease.

18 Mar 2021

Long noncoding RNA plays a vital role in mobilizing immune response after organ transplantation

A long noncoding RNA whose function was previously unknown turns out to play a vital role in mobilizing the immune response following a bone marrow transplant or solid organ transplantation.

17 Mar 2021

Beneficial effects of gene therapy can be seen in SCID-X1 patients decades after treatment

An international collaboration between Great Ormond Street Hospital, the UCL GOS Institute for Child Health and Harvard Medical School has shown that the beneficial effects of gene therapy can be seen decades after the transplanted blood stem cells has been cleared by the body.

17 Mar 2021

People with high BMI may now receive their COVID-19 vaccine in California

Now, California state allows individuals with one of ten comorbidities to get their COVID-19 jabs. This comes after obesity being tagged as COVID-19 vaccine eligibility.

16 Mar 2021

Researchers uncover potential new target for anti-COVID-19 therapies

Researchers from Cleveland Clinic's Florida Research and Innovation Center have identified a potential new target for anti-COVID-19 therapies.

16 Mar 2021

Transplant News and Research

First general selection criteria for lung transplantation in Covid-19 patients

Researchers offer large-scale screening of potential broad-spectrum SARS-CoV-2 antivirals

Unique approach to heart-liver transplant offers new hope for highly sensitized patients

Stem cell transplants offer long-term benefits for pediatric cancer patients receiving immunotherapy

Infliximab may hinder the effectiveness of some COVID-19 vaccines

Scientists launch clinical trial of CRISPR gene correction therapy in patients with sickle cell disease

Research consortium identifies cell stress mechanisms for chronic inflammatory liver disease

Simple, no-cost intervention can increase the number of prospective donors

Moffitt researchers use mathematical modeling to help explain outcomes of CAR T-cell therapy

Blood type-incompatible pediatric heart transplant shown to be as effective as the traditional approach

COVID vaccines have only 17% detectable antibodies against SARS-CoV-2 virus

Researchers develop innovative biosensor that can detect and quantitate SARS-CoV-2 infection

New technique traces genetic and epigenetic origins of DNA to reveal hidden cancers

Study finds two drugs capable of slowing bone marrow cancer progression

Virtual reality experiences can be used to train professionals in organ donation and transplants

Progesterone therapy may improve clinical outcomes for male COVID-19 patients

Long noncoding RNA plays a vital role in mobilizing immune response after organ transplantation

Beneficial effects of gene therapy can be seen in SCID-X1 patients decades after treatment

People with high BMI may now receive their COVID-19 vaccine in California

Researchers uncover potential new target for anti-COVID-19 therapies

Decoding Cannabis: Differentiating Hemp and Marijuana

Deciphering the Microbiome with The Microsetta Initiative

Leveraging the power of automation to boost research

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