Drug Discovery News and Research

RSS

The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

Newly developed fusion protein could improve COVID-19 research

Researchers at the Paul Scherrer Institute in Switzerland have developed a high-quality recombinant virus protein that could be applied in the development of vaccines against the 2019 novel coronavirus (2019-nCoV) and in the detection of novel viruses or antibodies.

30 Sep 2020

Researchers identify a new method to produce miniaturized antibodies

Researchers at the University of Bath in the UK and biopharma company UCB have found a way to produce miniaturized antibodies, opening the way for a potential new class of treatments for diseases.

30 Sep 2020

Phase 1 trial of new class of drugs shows promise in range of advanced cancers

A new precision drug which stops cancer from repairing its DNA has shown promise in an early-stage clinical trial - highlighting the potential of a new class of drugs known as ATR inhibitors.

29 Sep 2020

A special issue on the emerging COVID-19 infection

Acta Pharmaceutica Sinica B publishes special issue on 'Research on Emerging COVID-19 (Target, Mechanism, and Therapeutics)' edited by Hai-Bin Luo, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China; Shilin Chen, Institute of Chinese Materia Medica, Beijing, China and Peiqing Liu, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China.

29 Sep 2020

Blocking nuclear pore complex formation can help selectively kill cancer cells

Scientists at Sanford Burnham Prebys Medical Discovery Institute have shown that blocking the construction of nuclear pores complexes--large channels that control the flow of materials in and out of the cell nucleus--shrank aggressive tumors in mice while leaving healthy cells unharmed.

28 Sep 2020

AXT add Vieworks bio-imaging solutions to their preclinical imaging portfolio

AXT is excited to add the Vieworks range of bio-imaging systems to their preclinical imaging product portfolio. Their in-vivo imaging systems provide outstanding performance in bioluminescent and fluorescent imaging and represents excellent value.

From AXT Pty Ltd 26 Sep 2020

Researchers advance novel compounds to help treat C. difficile infection

Clostridioides difficile, or C. diff, is the leading cause of health care-associated infection in the U.S.

25 Sep 2020

New strategic collaboration to accelerate treatments for unmet medical needs in oncology

The University of Texas MD Anderson Cancer Center and Taiho Pharmaceutical Co., Ltd., today announced a three-year strategic collaboration to accelerate the development of treatments for significant unmet medical needs in oncology, including patients with brain metastases and those with cancers refractory to available therapies.

25 Sep 2020

Researchers use natural pigment for screening cell viability

Synthetic dyes are commonly used to assess the toxicity of chemical compounds in cell cultures. However, these dyes damage cells, rendering the cultures useless for long-term experiments.

25 Sep 2020

Gruthan Bioscience to develop new class of cholesterol-lowering drugs

Gruthan Bioscience, LLC, a Medical University of South Carolina startup based in Charleston, South Carolina, received a Small Business technology Transfer (STTR) award from the National Heart, Blood and Lung Institute in August to take the next step in developing a novel class of cholesterol-lowering drugs to treat familial hypercholesterolemia.

24 Sep 2020

Researchers identify a potential drug candidate for hand, foot and mouth disease

A study appearing next week in the journal Nature Communications offers some good news in the search for antiviral drugs for hard-to-treat diseases. Researchers have identified a potential new drug candidate against enterovirus 71, a common cause of hand, foot and mouth disease in infants and young children

22 Sep 2020

Drug used to treat breast and ovarian cancer can transform treatment for prostate cancer

A drug used to treat breast and ovarian cancer can extend the lives of some men with prostate cancer and should become a new standard treatment for the disease, concludes a major trial which is set to change clinical practice.

21 Sep 2020

Molecular imaging probe reveals Alzheimer's-related γ-secretase in rodents, macaques

Scientists at the Massachusetts General Hospital (MGH) have developed a molecular imaging probe to reveal Alzheimer's disease (AD)-related γ-secretase in rodents and macaques with translational potentials in humans.

18 Sep 2020

Scientists investigate how psychedelic drugs interact with brain cells at the molecular level

Psychedelic drugs such as LSD, psilocybin, and mescaline cause severe and often long-lasting hallucinations, but they show great potential in treating serious psychiatric conditions, such as major depressive disorder.

18 Sep 2020

Azelastine antihistamine inhibits SARS-CoV-2 infection in nasal tissue in vitro

In a study published on the bioRxiv preprint server, researchers from the University of Pécs, University of Vienna, and CEBINA GmbH, Vienna, show the ability of the antihistamine azelastine to inhibit SARS-CoV-2 infection in human nasal tissue in vitro.

16 Sep 2020

Curi Bio Announces Mantarray™ Platform for Analysis of 3D Engineered Muscle Tissues for Discovery of New Therapeutics

Curi Bio today announced the Mantarray™ platform for human-relevant 3D engineered muscle tissue (EMT) analysis.

From Curi Bio 16 Sep 2020

Study uncovers a promising new therapeutic approach for Duchenne muscular dystrophy

Scientists at Sanford Burnham Prebys Medical Discovery Institute, Fondazione Santa Lucia IRCCS, and Università Cattolica del Sacro Cuore in Rome have shown that pharmacological (drug) correction of the content of extracellular vesicles released within dystrophic muscles can restore their ability to regenerate muscle and prevent muscle scarring (fibrosis).

15 Sep 2020

Drug Discovery News and Research

Further Reading

Newly developed fusion protein could improve COVID-19 research

Researchers identify a new method to produce miniaturized antibodies

Phase 1 trial of new class of drugs shows promise in range of advanced cancers

A special issue on the emerging COVID-19 infection

Blocking nuclear pore complex formation can help selectively kill cancer cells

AXT add Vieworks bio-imaging solutions to their preclinical imaging portfolio

Researchers advance novel compounds to help treat C. difficile infection

New strategic collaboration to accelerate treatments for unmet medical needs in oncology

Researchers use natural pigment for screening cell viability

Gruthan Bioscience to develop new class of cholesterol-lowering drugs

Researchers identify a potential drug candidate for hand, foot and mouth disease

Drug used to treat breast and ovarian cancer can transform treatment for prostate cancer

Molecular imaging probe reveals Alzheimer's-related γ-secretase in rodents, macaques

Scientists investigate how psychedelic drugs interact with brain cells at the molecular level

Azelastine antihistamine inhibits SARS-CoV-2 infection in nasal tissue in vitro

Curi Bio Announces Mantarray™ Platform for Analysis of 3D Engineered Muscle Tissues for Discovery of New Therapeutics

Study uncovers a promising new therapeutic approach for Duchenne muscular dystrophy

New clinical trial shows combination of two innovative precision medicines could treat multiple cancers

Aigenpulse launches data analysis suite to automate flow cytometry

Evonetix partners with Analog Devices to fast track the development of DNA desktop writer

eBook: Essential guide to organoids in drug discovery eBook

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

Latest Life Science News