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DNA, or deoxyribonucleic acid, is the hereditary material in humans and almost all other organisms. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).

Molecular classifications of low-grade gliomas proposed

Two research teams have independently proposed molecular classification systems for grade II and III glioma based on three tumour markers, with each category displaying distinct clinical features and outcomes.

12 Jun 2015

Scientists identify gene mutation linked to anaplastic oligodendroglioma

Scientists have identified a gene mutation linked to the development of an aggressive form of brain cancer. Researchers found that errors in a gene known as TCF12 - which plays a key role in the formation of the embryonic brain are associated with more aggressive forms of a disease called anaplastic oligodendroglioma.

12 Jun 2015

Certain ARID1a mutations sensitize some tumors to PARP inhibitor drugs

Mutations in ARID1a, which are common in many cancer types, disrupt DNA damage repair in cancer cells, allowing the cancer to progress. This gene may also be an Achilles' heel when treating certain tumors, according to a team of researchers at The University of Texas MD Anderson Cancer Center.

12 Jun 2015

New gene mutations in ADAMTS family may contribute to outcomes in ovarian cancer

There is the Addams Family. And then there is the ADAMTS family. While one is mindless entertainment, the latter may prove to be a new genetic avenue for designing ovarian cancer treatment.

11 Jun 2015

Synthetic Genomics, Gen9 sign strategic licensing agreement for Febit intellectual property estate

Synthetic Genomics, Inc., a synthetic biology company advancing and innovating genomic science and technologies for transformative products and solutions, and Gen9 Inc., a pioneer in synthetic biology and leader in the development of scalable technologies for synthesizing and assembling DNA, today announced a strategic licensing agreement to leverage their respective strengths in synthetic biology technology development and commercialization.

11 Jun 2015

NeoGenomics announces launch of new NeoLAB assays to diagnose hematologic diseases

NeoGenomics, Inc., a leading provider of cancer-focused genetic testing services, announced today the launch of its first twelve tests in a new line of "liquid biopsy" or NeoLAB assays using next generation sequencing and other advanced molecular technologies.

11 Jun 2015

PGDx launches LungSelect product to identify genetic alterations in the plasma of NSCLC patients

Personal Genome Diagnostics, Inc., a provider of advanced cancer genome analysis and testing services, today announced the launch of its LungSelect product that identifies the most common, clinically actionable genetic alterations in the plasma of non-small cell lung cancer (NSCLC) patients.

11 Jun 2015

SQUIRE phase III study shows necitumumab improves median overall survival in squamous NSCLC patients

This week, Lancet Oncology reports results of a 1,093-person phase III clinical trial of the drug necitumumab (IMC-11F8) combined with chemotherapies gemcitabine and cisplatin against stage IV squamous non-small cell lung cancer. With addition of necitumumab, median overall survival was 11.5 months compared with median survival of 9.9 months with the two chemotherapies alone.

11 Jun 2015

New approach to classifying brain tumors could lead to significant improvements in diagnosis, treatment

A Case Comprehensive Cancer Center brain surgeon and neurosurgery professor is among the primary authors of a new approach to classifying tumors that could lead to significant improvements in their diagnosis and treatment. The research and recommendations appear online June 10 in The New England Journal of Medicine.

11 Jun 2015

Findings point to new therapy against prostate and other cancers

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have found that a drug candidate with anticancer potential can be activated by one of the body's natural responses to cellular stress. Once activated, the agent can kill prostate cancer cells.

11 Jun 2015

New study links sleep deprivation to etiology of biological aging in older adults

A new study suggests that one night of partial sleep deprivation promotes biological aging in older adults. Results show that one night of partial sleep deprivation activates gene expression patterns in peripheral blood mononuclear cells (PBMCs) consistent with increasing accumulation of damage that initiates cell cycle arrest and increases susceptibility to senescence.

11 Jun 2015

Creative Diagnostics announces launch of antibody generation service based on DNA immunization technology

Creative Diagnostics, the global diagnostics service and product supplier, is pleased to announce its launch of custom antibody production service based on DNA immunization technology. This DNA immunization technology allows high success rate in generation of high-affinity antibodies recognizing difficult-to-express proteins in their native confirmation, such as GPCRs, ion channels and other multiple membrane spanning proteins.

10 Jun 2015

EU research project to study how social inequalities influence healthy ageing

The Lifepath project, involving 15 institutions in Europe, the US and Australia, has been supported by a six million euro grant from the EU's Horizon 2020 programme...

10 Jun 2015

Study on how maternal proteins help regulate initial cell divisions during early development

Researchers in the University of Georgia's Regenerative Bioscience Center are visually capturing the first process of chromosome alignment and separation at the beginning of mouse development. The findings could lead to answers to questions concerning the mechanisms leading to birth defects and chromosome instability in cancer cells.

10 Jun 2015

MIPT researchers develop ultrasensitive nanomechanical sensor to identify tumor markers

Two young researchers working at the MIPT Laboratory of Nanooptics and Plasmonics, Dmitry Fedyanin and Yury Stebunov, have developed an ultracompact highly sensitive nanomechanical sensor for analyzing the chemical composition of substances and detecting biological objects, such as viral disease markers, which appear when the immune system responds to incurable or hard-to-cure diseases, including HIV, hepatitis, herpes, and many others.

10 Jun 2015

Manchester first to implement Congenica's Sapientia technology to provide fast, accurate diagnosis for genetic diseases

10,000 new patients a year are treated by the Manchester Centre for Genomic Medicine (MCGM) for a range of rare diseases including cancers, developmental disorders and disabilities including hearing and vision loss - diagnosis can be time-consuming and invasive.

10 Jun 2015

Massey researchers aim to develop models that can predict complications from stem cell transplantation

Researchers at VCU Massey Cancer Center's Bone Marrow Transplant Program have recently published findings from a phase 2 clinical trial that demonstrate lymphocyte recovery in related and unrelated stem cell transplant recipients generally falls into three patterns that are significantly associated with survival.

10 Jun 2015

OncoSec Medical reports net loss of $14.7 million for FY 2015

OncoSec Medical Inc., a company developing DNA-based intratumoral cancer immunotherapies, today announced financial results for the nine months ended April 30, 2015.

9 Jun 2015

Whole genome sequencing can help implement rapid-response infection control protocols

Whole genome sequencing can quickly isolate the specific strain of bacteria causing an outbreak, identify the source of contamination, and enable rapid infection prevention to stop the spread of infection, according to a study published today.

9 Jun 2015

Cell fusion triggers multiple genetic changes that convert normal cells to cancer cells

Although there is no one established universal cause of cancer, genetic changes are central to its development. The accumulation of spontaneous genetic changes, or mutations, that occur when cells divide can be hastened by exposure to carcinogens such as cigarette smoke (lung cancer) and infectious agents such as the papillomavirus (cervical cancer).

9 Jun 2015

DNA News and Research

Further Reading

Molecular classifications of low-grade gliomas proposed

Scientists identify gene mutation linked to anaplastic oligodendroglioma

Certain ARID1a mutations sensitize some tumors to PARP inhibitor drugs

New gene mutations in ADAMTS family may contribute to outcomes in ovarian cancer

Synthetic Genomics, Gen9 sign strategic licensing agreement for Febit intellectual property estate

NeoGenomics announces launch of new NeoLAB assays to diagnose hematologic diseases

PGDx launches LungSelect product to identify genetic alterations in the plasma of NSCLC patients

SQUIRE phase III study shows necitumumab improves median overall survival in squamous NSCLC patients

New approach to classifying brain tumors could lead to significant improvements in diagnosis, treatment

Findings point to new therapy against prostate and other cancers

New study links sleep deprivation to etiology of biological aging in older adults

Creative Diagnostics announces launch of antibody generation service based on DNA immunization technology

EU research project to study how social inequalities influence healthy ageing

Study on how maternal proteins help regulate initial cell divisions during early development

MIPT researchers develop ultrasensitive nanomechanical sensor to identify tumor markers

Manchester first to implement Congenica's Sapientia technology to provide fast, accurate diagnosis for genetic diseases

Massey researchers aim to develop models that can predict complications from stem cell transplantation

OncoSec Medical reports net loss of $14.7 million for FY 2015

Whole genome sequencing can help implement rapid-response infection control protocols

Cell fusion triggers multiple genetic changes that convert normal cells to cancer cells

eBook: Exploring the Cell Cycle and DNA Damage and Repair eBook

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Automating research - solutions and best practices

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