Lungs News and Research

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Bexarotene and erlotinib drugs effective in treating advanced lung cancer

Scientists have identified a drug combination, when used in advanced lung cancer patients, shows a survival advantage in patients who no longer respond to existing therapies.

3 Jun 2011

Lung-sparing surgery, photodynamic therapy improve survival of mesothelioma patients

Pleural mesothelioma patients who undergo lung-sparing surgery in combination with photodynamic therapy (PDT) show superior overall survival than patient treated using the conventional therapy of extrapleural pneumonectomy (EPP) with PDT, indicates new research from the Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania.

3 Jun 2011

Stereotactic body radiation therapy effective for patients with low-risk prostate cancer

In a multicenter clinical trial, UT Southwestern Medical Center researchers have found that higher doses of stereotactic radiation therapy requiring fewer treatments are safe and effective for patients with low-to-intermediate-risk prostate cancer.

3 Jun 2011

Syndax receives U.S. patent for entinostat to treat metastatic cancers

Syndax Pharmaceuticals, a clinical-stage epigenetics oncology company, today announced allowance by the United States Patent and Trademark Office of Patent Application Serial No. 12/549458 entitled: " N-(2-AMINOPHENYL)-4[N-(PYRIDINE-3-YL)- METHOXYCARBONYL—AMINOMETHYL]-BENZAMINE (MS-275) POLYMORPH B."

3 Jun 2011

Scientists discover new compound that inhibits bitterness

Although bitterness can sometimes be desirable - such as in the taste of coffee or chocolate - more often bitter taste causes rejection that can interfere with food selection, nutrition and therapeutic compliance. This is especially true for children. Now, scientists from the Monell Center and Integral Molecular describe the discovery of a compound that inhibits bitterness by acting directly on a subset of bitter taste receptors.

3 Jun 2011

Johns Hopkins researchers solve mystery of Warburg effect

It’s long been known that cancer cells eat a lot of sugar to stay alive. In fact, where normal, noncancerous cells generate energy from using some sugar and a lot of oxygen, cancerous cells use virtually no oxygen and a lot of sugar. Many genes have been implicated in this process and now, reporting in the May 27 issue of Cell, researchers at the Johns Hopkins University School of Medicine have discovered that this so-called Warburg effect is controlled.

2 Jun 2011

Clovis Oncology, Roche partner to develop in vitro PCR-based diagnostic test for NSCLC

Clovis Oncology, Inc. and Roche, announced today that they have entered into an agreement to develop an in vitro PCR based companion diagnostic test.

2 Jun 2011

AVEO’s ficlatuzumab-gefitinib Phase 1b/2 trial data against NSCLC to be presented at ASCO 2011

AVEO Pharmaceuticals, Inc. today announced results from the Phase 1b portion of its Phase 1b/2 clinical study of ficlatuzumab in combination with gefitinib in Asian subjects with non-small cell lung cancer.

2 Jun 2011

Patients with advanced NSCLC can benefit from less toxic combination of erlotinib, bevacizumab

The standard treatment for patients with advanced non-small cell lung cancer is a combination of two old-fashioned cytotoxic chemotherapy drugs. The combination, however, comes with substantial toxicity.

2 Jun 2011

Five organizations receive IASLC travel awards to attend 14th World Conference on Lung Cancer

Five advocacy organizations from India, Australia and the United States have been granted travel awards by the International Association for the Study of Lung Cancer (IASLC) to send representatives to the 14th World Conference on Lung Cancer, July 3-7 in Amsterdam.

2 Jun 2011

Niiki Pharma to present NKP-1339 Phase I trial against metastatic cancer at ASCO 2011

Niiki Pharma announced today that it will present interim data from the ongoing Phase I clinical study for its lead product, NKP-1339, at the 2011 American Society for Clinical Oncology meeting in Chicago, IL.

2 Jun 2011

Plasma resuscitation restores damage to endothelial glycocalyx after hemorrhagic shock

Using plasma rather than standard resuscitation fluids seems to improve survival in trauma patients with massive blood loss. Now a new study in animals suggests that this benefit may result from plasma's ability to restore the "endothelial glycocalyx," a special layer lining the blood vessels, reports the June issue of Anesthesia & Analgesia, official journal of the International Anesthesia Research Society.

1 Jun 2011

Nighttime heart and lung transplants do not affect patient survival

Despite concerns that surgeon fatigue is leading to dangerous complications for patients and data showing worse outcomes for many patients who undergo surgery at night, new Johns Hopkins research suggests that — in the case of heart and lung transplants — time of day has no affect on patient survival.

1 Jun 2011

Ontario's doctors urge people to quit smoking on ‘World No Tobacco Day’

Today is World No Tobacco Day and Ontario's doctors are taking the opportunity to remind people about the dangers of smoking and are urging smokers to talk to their doctor about how they can quit for good.

1 Jun 2011

Birth control pill safety issues raised

The U.S. Food and Drug Administration (FDA) has announced that it is looking at results from two studies that showed there is a higher risk of blood clots in women taking new birth control pills containing the compound drospirenone. Some brand names include Yaz, Yasmin, Beyaz, Ocella, Loryna, Gianvi, Safyral, Syeda and Zarah.

1 Jun 2011

Latest Breast cancer screening guidelines deemed unsafe by 80% women

Nearly 80 percent of women feel the new guidelines against breast cancer are unsafe as they stated that screening for those under 50 is not mandatory. The controversy over screening mammography flared up in late 2009, when a government-funded group of independent experts decided to change its recommendations. Instead of advising annual mammograms in all women age 40 and above, the U.S. Preventive Services Task Force (USPSTF) said women shouldn't routinely get screened until they hit 50, and those between 50 and 74 should only have mammograms every two years. But most of the women also seriously overestimate their risk of developing the disease, researchers from the University of Massachusetts Medical School in Worcester found.

31 May 2011

Spectranetics to showcase new advanced peripheral atherectomy simulation system at New Cardiovascular Horizons

Spectranetics Corporation today announced it will showcase a new advanced peripheral atherectomy simulation system at the New Cardiovascular Horizons meeting in New Orleans.

31 May 2011

YM announces updates on nimotuzumab clinical development program

YM BioSciences Inc., today provided an update on the development program for nimotuzumab, including its North American clinical program for nimotuzumab, manufacturing scale-up activities, and data presentations anticipated for nimotuzumab at the 2011 Annual Meeting of the American Society of Clinical Oncology.

31 May 2011

Study: E-waste linked to adverse effects on human health

In addition to its damaging effect on the environment and its illegal smuggling into developing countries, researchers have now linked e-waste to adverse effects on human health, such as inflammation and oxidative stress - precursors to cardiovascular disease, DNA damage and possibly cancer.

31 May 2011

Study suggests new therapeutic targets for virally-induced asthma attacks

When children with asthma get the flu, they often land in the hospital gasping for air. Researchers at Children's Hospital Boston have found a previously unknown biological pathway explaining why influenza induces asthma attacks.

30 May 2011

Lungs News and Research

Bexarotene and erlotinib drugs effective in treating advanced lung cancer

Lung-sparing surgery, photodynamic therapy improve survival of mesothelioma patients

Stereotactic body radiation therapy effective for patients with low-risk prostate cancer

Syndax receives U.S. patent for entinostat to treat metastatic cancers

Scientists discover new compound that inhibits bitterness

Johns Hopkins researchers solve mystery of Warburg effect

Clovis Oncology, Roche partner to develop in vitro PCR-based diagnostic test for NSCLC

AVEO’s ficlatuzumab-gefitinib Phase 1b/2 trial data against NSCLC to be presented at ASCO 2011

Patients with advanced NSCLC can benefit from less toxic combination of erlotinib, bevacizumab

Five organizations receive IASLC travel awards to attend 14th World Conference on Lung Cancer

Niiki Pharma to present NKP-1339 Phase I trial against metastatic cancer at ASCO 2011

Plasma resuscitation restores damage to endothelial glycocalyx after hemorrhagic shock

Nighttime heart and lung transplants do not affect patient survival

Ontario's doctors urge people to quit smoking on ‘World No Tobacco Day’

Birth control pill safety issues raised

Latest Breast cancer screening guidelines deemed unsafe by 80% women

Spectranetics to showcase new advanced peripheral atherectomy simulation system at New Cardiovascular Horizons

YM announces updates on nimotuzumab clinical development program

Study: E-waste linked to adverse effects on human health

Study suggests new therapeutic targets for virally-induced asthma attacks

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Automating research - solutions and best practices

How can microdialysis benefit drug development

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