Adenosine Triphosphate (ATP) News and Research

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Mitochondrial stress can trigger tumor-related metabolic shifts, study finds

Cancerous tumors must be fed. Their unregulated growth requires a steady stream of blood flow and nutrients. Thus, one way that researchers have tried to wipe out cancer is to target cells undergoing the metabolic shifts that enable a tumor's rapid growth.

7 Jul 2016

Scientists provide new insights into role of star-shaped brain cells in memory, learning

A molecule that enables strong communication between our brain and muscles appears to also aid essential communication between our neurons, scientists report.

23 Jun 2016

Mice study highlights vital role of liver in balancing fats and sugars

Sugar in the form of blood glucose provides essential energy for cells. When its usual dietary source — carbohydrates — is scarce, the liver can produce it with the aid of fat.

17 Jun 2016

Boosting mitochondria transport may facilitate neuronal regeneration

Researchers at the National Institute of Neurological Disorders and Stroke have discovered that boosting the transport of mitochondria along neuronal axons enhances the ability of mouse nerve cells to repair themselves after injury.

8 Jun 2016

UT Southwestern study offers more insight into cholesterol transporter

Using X-ray crystallography, UT Southwestern Medical Center researchers have determined the 3-D atomic structure of a human sterol transporter that helps maintain cholesterol balance.

27 May 2016

Researchers partially restore lost function of isolated cystic fibrosis lung cells

In experiments with isolated cystic fibrosis lung cells, University of Alabama at Birmingham researchers and colleagues from two other institutions have partially restored the lost function of those cells.

26 May 2016

Single enzyme doing the work of a trio could offer precise way to treat diseases

Researchers identified a single enzyme doing the work of a trio thought necessary to control a common cellular signaling process being pursued as a therapeutic target.

24 May 2016

Rapamycin drug could target neural damage linked to Leigh syndrome

Salk Institute scientists showed how an FDA-approved drug boosts the health of brain cells by limiting their energy use. Like removing unnecessary lighting from a financially strapped household to save on electricity bills, the drug--called rapamycin--prolongs the survival of diseased neurons by forcing them to reduce protein production to conserve cellular energy.

27 Apr 2016

Researchers reach milestone in developing non-hormonal approach to male contraception

Researchers studying strategies to develop a non-hormonal approach to male contraception have reached an important milestone in their work, discovering a way to produce a key enzyme found only in sperm in sufficient quantities that they can begin designing drugs to stop the sperm from swimming to the egg.

13 Apr 2016

Researchers identify vital inflammatory mechanisms in type 1 diabetes, obesity-related kidney dysfunction

In a new study, published in the online edition of the journal EBioMedicine, a multi-disciplinary team led by researchers at University of California, San Diego School of Medicine has identified key inflammatory mechanisms underlying type 1 diabetes and obesity-related kidney dysfunction.

11 Apr 2016

University of Copenhagen researchers discover Achilles heel of bacteria

Drug resistant bacteria are fast becoming one of the big worries of the 21 century. Now researchers at the University of Copenhagen have discovered a previously unknown weakness; an "Achilles heel", of bacteria. Their discovery, a crucial step in bacteria's energy metabolism, may be the first step in developing an entirely novel form of antibiotics

22 Mar 2016

Manipulation of NAD could lead to potential therapy for acute kidney injury

Approximately one out of five hospitalized adults and one out of three hospitalized children worldwide experience acute kidney injury, the sudden loss of kidney function. Many different factors, including surgery, chemotherapy or shock, can lead to acute kidney injury, but exactly why the kidneys are so vulnerable to these and other stressors has not been well understood.

19 Mar 2016

Research could pave way for new generation of anti-cancer drugs

New research has identified a first step in the design of a new generation of anti-cancer drugs that include an agent to inhibit resistance to their effectiveness.

9 Mar 2016

Inhibition of mitochondrial calcium uptake specifically toxic to cancer cells

Inhibiting the transfer of calcium ions into the cell's powerhouse is specifically toxic to cancer cells, according to an article published this week in Cell Reports by researchers from the Perelman School of Medicine at the University of Pennsylvania.

4 Mar 2016

Over-expression of heme oxygenase-1 enzyme protects the heart from doxorubicin damage

Life-threatening heart damage is an adverse side effect of the cancer drug doxorubicin, damage that also limits the use of newer chemotherapeutic agents such as trastuzumab and imatinib. The ability to protect the heart from these side effects would benefit patients, including cancer survivors who are at risk of developing heart damage years later, and it also could allow safer use of these drugs at higher doses.

26 Feb 2016

CPMC study discovers six genes that affect sleep duration

The Coriell Personalized Medicine Collaborative, a research initiative exploring the utility of genetic information in the clinical setting, has published a study and identified six noteworthy genes that affect human sleep duration.

13 Jan 2016

Researchers reveal specific enzyme responsible for sensing energy source that fuels growth of cancer cells

An international research team formed by a University of Cincinnati cancer researcher has shown for the first time that a specific enzyme is responsible for sensing the available supply of GTP, an energy source that fuels the uncontrolled growth of cancer cells. The research underscores the enzyme's potential to become a therapeutic target for future cancer drugs.

11 Jan 2016

Study on myosins may lead to therapies for muscle diseases, cancers

Understanding how tiny molecular motors called myosins use energy to fuel biological tasks like contracting muscles could lead to therapies for muscle diseases and cancers, says a team of researchers led by Penn State College of Medicine scientists.

22 Dec 2015

Scientists outline molecular blueprints of tiny cellular 'nanomachine'

Scientists have drawn up molecular blueprints of a tiny cellular ‘nanomachine’, whose evolution is an extraordinary feat of nature, by using one of the brightest X-ray sources on Earth.

21 Dec 2015

Scientists reveal major players in severe muscle damage caused by sepsis

Scientists from the Institut Pasteur, Paris Descartes University, Sainte-Anne Hospital and the CNRS have recently published a paper in Nature Communications in which they reveal major players in the severe muscle damage caused by sepsis, or septicemia, which explains why many patients suffer debilitating muscle impairment long-term after recovery.

17 Dec 2015