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DNA, or deoxyribonucleic acid, is the hereditary material in humans and almost all other organisms. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).

Additional preclinical data on DelMar’s VAL-083 to treat temozolomide-resistant GBM presented at AACR

DelMar Pharmaceuticals, Inc., a biopharmaceutical company focused on developing and commercializing proven cancer therapies in new orphan drug indications, presented additional preclinical data at the American Association of Cancer Research (AACR) Advances in Brain Cancer Research Conference on the potential for its lead product candidate VAL-083 (dianhydrogalactitol) to treat patients with temozolomide-resistant glioblastoma multiforme (GBM).

1 Jun 2015

New clinical studies on Myriad Genetics myChoice HRD companion diagnostic test presented at ASCO 2015

Myriad Genetics, Inc. today announced new clinical studies on its myChoice HRD companion diagnostic test at the 2015 American Society of Clinical Oncology annual meeting being held in Chicago, Ill.

1 Jun 2015

Precision medicine helps improve patient health and reduces risk of side effects, says Penn Medical School dean

The rapidly emerging field of precision medicine is a "disruptive innovation" that offers the possibility of remarkably fine-tuned remedies to improve patient health while minimizing the risk of harmful side effects, says J. Larry Jameson, MD, PhD, dean of the Perelman School of Medicine and executive vice president of the University of Pennsylvania for the Health System, in this week's issue of the New England Journal of Medicine.

1 Jun 2015

Mistakes in mismatch repair genes may accurately predict response to certain immunotherapy drugs

In a report of a proof-of-principle study of patients with colon and other cancers for whom standard therapies failed, researchers at the Johns Hopkins Kimmel Cancer Center say that mistakes in so-called mismatch repair genes, first identified by Johns Hopkins and other scientists two decades ago, may accurately predict who will respond to certain immunotherapy drugs known as PD-1 inhibitors. Such drugs aim to disarm systems developed by cancer cells to evade detection and destruction by immune system cells.

30 May 2015

Researchers uncover critical role for two proteins in chromatin structure

A team of researchers at the IRCM led by François Robert, PhD, uncovered a critical role for two proteins in chromatin structure. Their breakthrough, recently published in the scientific journal Molecular Cell, helps explain how DNA is organized in our cells. This discovery could lead to a better understanding of what causes certain types of cancer, such as lymphoma.

30 May 2015

Researchers awarded $3.86 million NIH grant to tackle the issue of 'mosaicism' in schizophrenia

Why does schizophrenia happen, and how can we improve treatment for it? These basic questions persist despite years of research on one of the most puzzling, and debilitating, mental illnesses. Now, a University of Michigan Medical School team and their colleagues will take a new approach to addressing these questions by searching for genetic clues in postmortem brain tissues of people with and without schizophrenia.

30 May 2015

Myriad Genetics to highlight new clinical studies on myRisk Hereditary Cancer test at ASCO 2015

Myriad Genetics, Inc. today announced it will highlight several new clinical studies on its myRisk Hereditary Cancer molecular diagnostic test at the 2015 American Society of Clinical Oncology annual meeting being held in Chicago, Ill.

30 May 2015

Myriad Genetics announces new clinical studies on myChoice HRD companion diagnostic test at ASCO 2015

Myriad Genetics, Inc. today announced new clinical studies on its myChoice HRD companion diagnostic test at the 2015 American Society of Clinical Oncology annual meeting being held in Chicago, Ill.

30 May 2015

SNPs predict sunitinib outcome in mRCC

Research has confirmed that single nucleotide polymorphisms in genes related to the processing of sunitinib influence the outcome of treatment for metastatic renal cell carcinoma.

29 May 2015

Study expands understanding of the production of ET-743 compound

For decades, scientists have known that ET-743, a compound extracted from a marine invertebrate called a mangrove tunicate, can kill cancer cells. The drug has been approved for use in patients in Europe and is in clinical trials in the U.S.

29 May 2015

DNA analysis reveals how ovarian cancer takes genetic twists and turns to outsmart chemotherapy

The largest complete DNA analysis of ovarian cancer in the world, published overnight in Nature, has revealed unprecedented new insight into the genetic twists and turns a deadly form of the disease takes to outsmart chemotherapy, potentially changing treatment approaches for women around the world.

29 May 2015

Study reveals new molecular mechanism that helps protect genome from harmful effect of UV radiations

Researchers have uncovered a new molecular mechanism whereby human cells protect their genome from the detrimental effect of UV radiation and govern DNA replication in cellular mitosis, which, when it malfunctions, leads to harmful results.

29 May 2015

Investigating epigenetic marks in ancient DNA could help understand health of ancient populations

A new study by anthropologists from The University of Texas at Austin shows for the first time that epigenetic marks on DNA can be detected in a large number of ancient human remains, which may lead to further understanding about the effects of famine and disease in the ancient world.

29 May 2015

Penn State to receive $1.84 million over five years to explore craniosynostosis

Penn State will receive $1.84 million over five years as a subcontract on a National Institutes of Health grant through the Icahn School of Medicine at Mount Sinai Hospital, New York, N.Y., to explore craniosynostosis, a birth defect that includes facial and cranial dysmorphology.

28 May 2015

Panorama SNP-based non-invasive prenatal test can detect complete molar pregnancy

Natera, Inc., a leader in non-invasive genetic testing, today announced a study published in Ultrasound in Obstetrics & Gynecology demonstrating that the Panorama single-nucleotide polymorphism (SNP)-based non-invasive prenatal test (NIPT) can identify a complete molar pregnancy in the first trimester.

From Natera 28 May 2015

IDT to host instructive talk on accelerating synthetic biology at ASM General Meeting

Integrated DNA Technologies will host an instructive talk on accelerating synthetic biology at the American Society for Microbiology General Meeting in New Orleans, Louisiana on Sunday May 31, 2015 at 11am CDT.

From Integrated DNA Technologies 28 May 2015

EKF Diagnostics highlighting cancer molecular diagnostics products at ASCO 2015

EKF subsidiary, Selah Genomics’ newly introduced PrecisionPath™ next generation sequencing (NGS) technology cancer test will be a key focus on Booth #19141...

From EKF Diagnostics 28 May 2015

Congress needs to act to incentivize development of genomic data systems

The latest generation of genomic testing offers a chance for significant improvements in patient care, disease prevention, and possibly even the cost-effectiveness of healthcare, but Congress needs to act to incentivize the development of the massive data systems that doctors and regulators will need in order to make these tests safe and effective for patients.

28 May 2015

Six research teams awarded grant to accelerate discovery of new drugs for brain, nervous system disorders

CQDM, Brain Canada and the Ontario Brain Institute award close to $8.5M to six (6) multi-disciplinary and multi-provincial research teams across Canada to address unmet needs in neuroscience within their Focus on Brain strategic initiative. To this amount, $1.5M is added from the various research entities involved as in-kind contributions.

27 May 2015

Quicker, more effective, and more reliable protocols for RNA extractions

Ask any molecular plant biologist about RNA extractions and you might just open up the floodgates to the woes of troubleshooting. RNA extraction is a notoriously tricky and sensitive lab procedure. New protocols out of the University of Florida are quicker, more effective, and more reliable than previous methods.

27 May 2015

DNA News and Research

Further Reading

Additional preclinical data on DelMar’s VAL-083 to treat temozolomide-resistant GBM presented at AACR

New clinical studies on Myriad Genetics myChoice HRD companion diagnostic test presented at ASCO 2015

Precision medicine helps improve patient health and reduces risk of side effects, says Penn Medical School dean

Mistakes in mismatch repair genes may accurately predict response to certain immunotherapy drugs

Researchers uncover critical role for two proteins in chromatin structure

Researchers awarded $3.86 million NIH grant to tackle the issue of 'mosaicism' in schizophrenia

Myriad Genetics to highlight new clinical studies on myRisk Hereditary Cancer test at ASCO 2015

Myriad Genetics announces new clinical studies on myChoice HRD companion diagnostic test at ASCO 2015

SNPs predict sunitinib outcome in mRCC

Study expands understanding of the production of ET-743 compound

DNA analysis reveals how ovarian cancer takes genetic twists and turns to outsmart chemotherapy

Study reveals new molecular mechanism that helps protect genome from harmful effect of UV radiations

Investigating epigenetic marks in ancient DNA could help understand health of ancient populations

Penn State to receive $1.84 million over five years to explore craniosynostosis

Panorama SNP-based non-invasive prenatal test can detect complete molar pregnancy

IDT to host instructive talk on accelerating synthetic biology at ASM General Meeting

EKF Diagnostics highlighting cancer molecular diagnostics products at ASCO 2015

Congress needs to act to incentivize development of genomic data systems

Six research teams awarded grant to accelerate discovery of new drugs for brain, nervous system disorders

Quicker, more effective, and more reliable protocols for RNA extractions

eBook: A guide to RNA sequencing eBook

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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