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Novel brain-permeable Cdk5 inhibitor alters neurobehavior in mice

James Bibb, Ph.D., and colleagues have described a novel preclinical drug that could have the potential to combat depression, brain injury and diseases that impair cognition. The drug, which notably is brain-permeable, acts to inhibit the kinase enzyme Cdk5.

20 May 2022

Study outlines risk factors for autoimmune hepatitis after liver transplant

A multicenter study performed by a large international consortium that includes UT Southwestern has outlined a set of risk factors and outcomes for patients with autoimmune hepatitis (AIH) that recurs after liver transplantation.

20 May 2022

Blood-based biomarker can predict the benefit of immunotherapy to lung cancer patients

A blood-based tumor biomarker can predict the benefit of immunotherapy to patients with non-small cell lung cancer, according to a study published in Nature Medicine.

20 May 2022

Study demonstrates that ATV006 is orally bioavailable and has potent efficacy against SARS-CoV-2

A new study has revealed that ATV006, which is a 5′-hydroxyl-isobutyryl prodrug, possesses extraordinary oral pharmaco-kinetic (PK) profiles in rats and cynomolgus monkeys and exhibited significant antiviral activity against ancestral SARS-COV-2 strain as well as VOCs.

20 May 2022

Hyperinsulinemic patients with breast cancer may be responsive to metabolism-targeting treatments

Scientists at Yale Cancer Center have found that patients with breast cancer and high levels of insulin in the blood may be responsive to metabolism-targeting treatments, which in turn may improve the effectiveness of subsequent chemotherapy treatments.

20 May 2022

Multi-center trial shows promising results for implant-free interatrial shunt device to treat heart failure patients

Results from early clinical evaluation of the Alleviant System to treat heart failure patients with preserved and reduced ejection fraction (HFpEF and HFrEF) was presented today as late-breaking clinical research at the Society for Cardiovascular Angiography & Interventions (SCAI) 2022 Scientific Sessions.

20 May 2022

Clopidogrel monotherapy linked with reduced risk of net adverse clinical events, study finds

Results from a real-world study investigating safety and effectiveness of clopidogrel versus aspirin monotherapy beyond 12 months after PCI in high-risk patients during the chronic maintenance period.

20 May 2022

Household contact management could help avert 20% of the multi-drug resistant TB cases in children

One in five multi-drug resistant (MDR) tuberculosis (TB) cases in children under the age of 15 could be averted every year by household contact management, according to a new modeling study published in The Lancet Global Health.

20 May 2022

Probiotic supplements accelerate the maturation of microbiome in extremely preterm infants

University of Calgary researchers have shown probiotic supplements can help form a healthy microbiome in the gut of the tiniest infants who are born without a fully formed gut microbiome.

20 May 2022

‘Watch and wait’ approach may improve outcomes for very frail patients than emergency surgery

New research published in Anaesthesia (a journal of the Association of Anaesthetists) shows that for patients who are very frail, it may be better to adopt a 'watch and wait' approach rather than proceeding to emergency surgery for five common medical emergencies.

20 May 2022

Existing drug may reduce damage after spinal cord injury, research shows

Scientists from the University of Birmingham have shown an existing drug may reduce damage after spinal cord injury, by blocking the inflammatory response in the spinal cord.

20 May 2022

A step-by-step plan to create a digital twin of the human immune system

An article published May 20 in Nature Digital Medicine provides a step-by-step plan for an international effort to create a digital twin of the human immune system.

20 May 2022

The enigma of post-acute infection syndromes

In a recent review published in the journal Nature Medicine, researchers summarized known literature findings of the unexplained post-acute infection syndromes (PAISs).

20 May 2022

Study validates long-term safety and efficacy of Harmony transcatheter pulmonary valve implant

A study of one year outcomes in the largest cohort to date of Harmony transcatheter pulmonary valve (TPV) patients with congenital heart disease (CHD) and severe pulmonary regurgitation (PR) was presented today as late-breaking clinical research at the Society for Cardiovascular Angiography & Interventions 2022 Scientific Sessions.

19 May 2022

Genetic variants may help explain the variability in COVID-19 severity, study suggests

Though underlying medical conditions play an important role, many aspects of why COVID-19 severity can differ vastly from one to another has remained unclear.

19 May 2022

Facebook posts may help identify people at risk for hazardous drinking habits

Alcoholism can be a difficult condition to diagnose, especially in cases where individuals' drinking habits are not noticed and physical symptoms have not yet manifested.

19 May 2022

‘Sting’ protein’s response to clean up damaged brain cells may accelerate Parkinson’s disease progression

In studies with mouse and human tissue, as well as live mice, Johns Hopkins Medicine researchers report that a snag in the normal process of cleaning up broken DNA in brain cells may hasten the progression of Parkinson's disease.

19 May 2022

Physician mistreatment and discrimination can have a ripple effect on the health care system

In a recent survey of more than 6,500 physicians from across the United States representing a broad spectrum of racial and ethnic diversity, nearly 30% of respondents reported experiencing discrimination and mistreatment from patients or patients' family members or visitors.

19 May 2022

Molecular profiling of diseased joints could transform treatment for rheumatoid arthritis patients

New research from Queen Mary University of London, published in Nature Medicine, has shown that molecular profiling of the diseased joint tissue can significantly impact whether specific drug treatments will work to treat rheumatoid arthritis (RA) patients.

19 May 2022

Study estimates the global RSV disease burden in children under five in 2019

A new study published in The Lancet estimates that RSV-attributable acute lower respiratory infection was responsible for more than 100,000 deaths in children under five across the globe in 2019.

19 May 2022

Medicine News and Research

Novel brain-permeable Cdk5 inhibitor alters neurobehavior in mice

Study outlines risk factors for autoimmune hepatitis after liver transplant

Blood-based biomarker can predict the benefit of immunotherapy to lung cancer patients

Study demonstrates that ATV006 is orally bioavailable and has potent efficacy against SARS-CoV-2

Hyperinsulinemic patients with breast cancer may be responsive to metabolism-targeting treatments

Multi-center trial shows promising results for implant-free interatrial shunt device to treat heart failure patients

Clopidogrel monotherapy linked with reduced risk of net adverse clinical events, study finds

Household contact management could help avert 20% of the multi-drug resistant TB cases in children

Probiotic supplements accelerate the maturation of microbiome in extremely preterm infants

‘Watch and wait’ approach may improve outcomes for very frail patients than emergency surgery

Existing drug may reduce damage after spinal cord injury, research shows

A step-by-step plan to create a digital twin of the human immune system

The enigma of post-acute infection syndromes

Study validates long-term safety and efficacy of Harmony transcatheter pulmonary valve implant

Genetic variants may help explain the variability in COVID-19 severity, study suggests

Facebook posts may help identify people at risk for hazardous drinking habits

‘Sting’ protein’s response to clean up damaged brain cells may accelerate Parkinson’s disease progression

Physician mistreatment and discrimination can have a ripple effect on the health care system

Molecular profiling of diseased joints could transform treatment for rheumatoid arthritis patients

Study estimates the global RSV disease burden in children under five in 2019

Decoding Cannabis: Differentiating Hemp and Marijuana

Deciphering the Microbiome with The Microsetta Initiative

Leveraging the power of automation to boost research

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