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Receptos begins RPC1063 Phase 1 clinical study in patients with multiple sclerosis

Receptos, announced today that their highly selective sphingosine-1-phosphate receptor 1 agonist, RPC1063, has been administered to the first subject in a single-ascending and multiple-ascending dose design Phase 1 clinical safety study.

28 Jan 2011

Iniparib Phase III study in metastatic triple-negative breast cancer does not meet primary goal

Sanofi-aventis and its subsidiary, BiPar Sciences, today announced that a randomized Phase III trial evaluating iniparib (BSI-201) in patients with metastatic triple-negative breast cancer (mTNBC) did not meet the pre-specified criteria for significance for co-primary endpoints of overall survival and progression-free survival

28 Jan 2011

Provectus announces completion of PV-10 Phase 1 trial in patients with liver cancer

Provectus Pharmaceuticals, a development-stage oncology and dermatology biopharmaceutical company, has completed patient accrual and treatment of all subjects in its Phase 1 clinical trial of PV-10 for liver cancer.

27 Jan 2011

NHS reforms & proposed spending questioned

According to John Appleby, Chief Economist at the King’s Fund, deaths from heart attacks and cancer in the UK are falling despite lower spending on health than in countries such as France. This, he said calls attention to the Government’s claim that poor outcomes justify a £1.4 billion restructuring of the NHS that will pass control of budgets from managers to GPs. He said, “Comparing health outcomes across countries is complex and not simply down to healthcare spending, but these trends must challenge one of the government’s key justifications for reforming the NHS.”

27 Jan 2011

Flood-borne diseases make their appearance

In the wake of Queensland’s devastating floods there are warnings to residents, volunteers and others regarding protection against diseases. Australian Medical Association Queensland president-elect Dr Richard Kidd said he expected a number of diseases to appear as a result of people coming in contact with floodwaters and especially the mud left behind.

27 Jan 2011

Baxter fourth quarter net income declines 26% to $423 million

Baxter International Inc. today announced its financial results for the fourth quarter of 2010, and provided its financial outlook for the first quarter and full-year 2011.

From Baxter International Inc. 27 Jan 2011

'Phenotype switching' helps bacteria lie dormant inside host cells and become a reservoir for relapsing infections

A new study into Staphylococcus aureus, the bacterium which is responsible for severe chronic infections worldwide, reveals how the bacteria have developed a strategy of hiding within host cells to escape the immune system as well as many antibacterial treatments. The research, published by EMBO Molecular Medicine, demonstrates how 'phenotype switching' enables bacteria to adapt to their environmental conditions, lie dormant inside host cells and become a reservoir for relapsing infections.

27 Jan 2011

NIH study helps explain survival rate discrepancy between cardiac arrest in public and home

Cardiac arrests that can be treated by electric stimulation, also known as shockable arrests, were found at a higher frequency in public settings than in the home, according to a National Institutes of Health-funded study appearing in the Jan. 27 issue of the New England Journal of Medicine.

27 Jan 2011

Feeding regimens may improve respiratory health in premature babies with lung disease

Improving lung function in premature babies with a severe lung disease may be linked to their feeding regimen, according to a new University of Michigan study.

27 Jan 2011

Research shows how pathogenic bacteria hide inside host cells

A new study into Staphylococcus aureus, the bacterium which is responsible for severe chronic infections worldwide, reveals how bacteria have developed a strategy of hiding within host cells to escape the immune system as well as many antibacterial treatments. The research, published by EMBO Molecular Medicine, demonstrates how ‘phenotype switching’ enables bacteria to adapt to their environmental conditions, lie dormant inside host cells and become a reservoir for relapsing infections.

26 Jan 2011

ASCO urges physicians, medical schools to improve quality of life for people with cancer

The American Society of Clinical Oncology today called on physicians, medical schools, insurers, and others to help improve quality of life for people with advanced cancer.

25 Jan 2011

ASU Biodesign Institute hosts international research consortium on early detection of lung cancer

To address the latest issues on the early detection of lung cancer, the Biodesign Institute at Arizona State University will host an international research consortium in Scottsdale, Ariz., Feb. 25-26.

25 Jan 2011

Composer Fr-d-ric Chopin probably had temporal lobe epilepsy

The composer Fr-d-ric Chopin, who regularly hallucinated, probably had temporal lobe epilepsy throughout his short life, reveals research published online in Medical Humanities. Hallucinations typically feature in seizure disorders, they say.

25 Jan 2011

Eisai's eritoran ACCESS study in severe sepsis does not meet primary endpoint

Based on the preliminary findings from the ACCESS (A Controlled Comparison of Eritoran and Placebo in Patients with Severe Sepsis) trial, Eisai Inc. announced today that the company will not submit marketing authorization applications to regulatory authorities in the United States, the European Union and Japan by the end of the fiscal year (March 31, 2011), as previously planned.

25 Jan 2011

LHSC performs complicated aortic valve bypass surgery using Correx AVB device

Doctors at London Health Sciences Centre (LHSC) are the first in the world to use a new implantable surgical device that promises to revolutionize aortic valve bypass surgery.

25 Jan 2011

University of California study may shed light on human ability to adapt hypoxia

In an important study that may shed light on human ability to adapt to hypoxia, or inadequate levels of oxygen, researchers at the University of California, San Diego School of Medicine have proven that the genome of flies exposed to long-term hypoxia are changed to permanently affect gene expression.

24 Jan 2011

Breast and lung cancer: Shared risk and treatment

New research has shown that women who are heavy smokers before menopause, especially prior to giving birth, may significantly increase their risk of developing breast cancer. In the US study looking at almost 150,000 women from the Nurses’ Health Study; it was found that breast cancer rates increased with higher levels of smoking among younger age groups. The study appeared in the journal Archives of Internal Medicine.

24 Jan 2011

ArQule's ARQ 197 Phase 1 clinical trial results in colorectal cancer presented at ASCO 2011

ArQule, Inc. today announced the presentation of Phase 1 results of a clinical trial among patients with metastatic colorectal cancer (CRC) treated with ARQ 197, a selective small molecule inhibitor of the c-MET receptor tyrosine kinase, in combination with irinotecan and cetuximab. ARQ 197 is under development by Daiichi Sankyo Co., Ltd. and ArQule.

24 Jan 2011

NHLBI, HeartWare award $13.3M to study benefits of heart devices for heart failure

The University of Michigan Cardiovascular Center and the University of Pittsburgh have been awarded $13.3 million to explore the potential benefits of heart devices for the large and growing group of Americans with heart failure.

24 Jan 2011

Breakthrough in understanding mechanisms behind hereditary alpha-1-antitrypsin deficiency

Researchers from the Royal College of Surgeons in Ireland (RCSI) and Beaumont Hospital have made a breakthrough in understanding the mechanisms behind the most severe form of hereditary emphysema and how protein treatments can improve the condition. The findings of this study may also lead to new treatments for patients with smoker's emphysema.

24 Jan 2011

Lungs News and Research

Receptos begins RPC1063 Phase 1 clinical study in patients with multiple sclerosis

Iniparib Phase III study in metastatic triple-negative breast cancer does not meet primary goal

Provectus announces completion of PV-10 Phase 1 trial in patients with liver cancer

NHS reforms & proposed spending questioned

Flood-borne diseases make their appearance

Baxter fourth quarter net income declines 26% to $423 million

'Phenotype switching' helps bacteria lie dormant inside host cells and become a reservoir for relapsing infections

NIH study helps explain survival rate discrepancy between cardiac arrest in public and home

Feeding regimens may improve respiratory health in premature babies with lung disease

Research shows how pathogenic bacteria hide inside host cells

ASCO urges physicians, medical schools to improve quality of life for people with cancer

ASU Biodesign Institute hosts international research consortium on early detection of lung cancer

Composer Fr-d-ric Chopin probably had temporal lobe epilepsy

Eisai's eritoran ACCESS study in severe sepsis does not meet primary endpoint

LHSC performs complicated aortic valve bypass surgery using Correx AVB device

University of California study may shed light on human ability to adapt hypoxia

Breast and lung cancer: Shared risk and treatment

ArQule's ARQ 197 Phase 1 clinical trial results in colorectal cancer presented at ASCO 2011

NHLBI, HeartWare award $13.3M to study benefits of heart devices for heart failure

Breakthrough in understanding mechanisms behind hereditary alpha-1-antitrypsin deficiency

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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