Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

Irresistin: a ‘poison arrow’ to defeat antibiotic resistance

News-Medical speaks to Dr. James Martin and Dr. Zemer Gitai from Princeton University about their research which led to the discovery of a new antibiotic.

1 Jul 2020

Bioengineered uterine tissue can support normal pregnancies, study shows

In new research from the Wake Forest Institute for Regenerative Medicine (WFIRM), scientists have shown that bioengineered uteri supported fertilization, fetal development, and live birth with normal offspring.

29 Jun 2020

Clinically approved drugs could disrupt SARS-CoV-2 from hijacking cells

An international team of researchers has analyzed how SARS-CoV-2, the virus that causes COVID-19, hijacks the proteins in its target cells.

29 Jun 2020

3D structure of Aβ protein assemblies reveals a new mechanism of toxicity

The brains of millions of people suffering from Alzheimer´s disease (AD) are slowly and inescapably being depleted of neurons, which leads to the characteristic loss of memory and cognitive function associated with this condition.

29 Jun 2020

Sanford Burnham Prebys announces research agreement with Lilly to identify COVID-19 antibodies

Sanford Burnham Prebys Medical Discovery Institute today announced a research agreement with Eli Lilly and Company (Lilly) to characterize Lilly's next-generation anti-SARS-CoV-2 antibodies.

29 Jun 2020

WFIRM and Oracle Health Sciences team up to pair Body-on-a-Chip with data analytics

The Wake Forest Institute for Regenerative Medicine and Oracle Health Sciences have teamed as part of the Innovation Quarter's iQ Healthtech Labs to develop a consortium of industry, government, and academic members that will study novel approaches to establishing the safety of new drugs that are nearing clinical investigation in humans and FDA approval.

26 Jun 2020

International study uncovers three molecules with potential for treating epilepsy

A major international study has uncovered three molecules that have the potential to be developed into new drugs to treat epilepsy.

26 Jun 2020

Sygnature Discovery strengthens senior management team with appointment of Dr Paul Overton

Sygnature Discovery, a leading independent integrated drug discovery and pre-clinical solutions provider, has strengthened its senior management team with the appointment of Dr Paul Overton as Senior VP of Business Development, focusing primarily on expanding Sygnature’s North American market.

From Sygnature Discovery Limited 26 Jun 2020

New virtual incubator can catalyze early-stage drug discovery and development

Samsara BioCapital, a leading life sciences investment firm, Evotec SE, a global drug discovery alliance and development partnership company (Frankfurt Stock Exchange: EVT, MDAX/TecDAX, ISIN: DE0005664809), and KCK Ltd., a family investment fund, today announced the launch of Autobahn Labs, a novel virtual incubator partnering with top academic and research institutions to catalyze early-stage drug discovery and development.

24 Jun 2020

UK announces research partnership with Atomwise to explore potential COVID-19 therapies

The University of Kentucky announced a research collaboration with Atomwise, an industry leader in using artificial intelligence (AI) for small molecule discovery, to explore potential COVID-19 therapies

23 Jun 2020

Prior infection provides protection against SARS-CoV-2 virus in hamsters

In an animal model for COVID-19 that shares important features of human disease, scientists at the University of Wisconsin–Madison, the University of Tokyo and the Icahn School of Medicine at Mount Sinai show that prior infection with the SARS-CoV-2 virus provides protection against reinfection, and treatment with convalescent serum limits virus replication in their lungs.

22 Jun 2020

Organoids can help provide new level of accuracy in prescribing anti-cancer therapies

Precision medicine, using the power of the human genome to diagnose and treat patients, is about to get even more precise.

22 Jun 2020

UQ superbug drug discoveries will be fast-tracked under international research deal

Antibiotics discovered at The University of Queensland will be fast-tracked under an US$11 million international research deal.

22 Jun 2020

UAH researchers assess treatment efficacy of naturally occurring compounds against COVID-19

The Baudry Lab at The University of Alabama in Huntsville has identified 125 naturally occurring compounds that have a computational potential for efficacy against the COVID-19 virus from the first batch of 50,000 rapidly assessed by a supercomputer.

22 Jun 2020

Researchers develop tool to identify proteins associated with drug side effects

A multi-institutional group of researchers led by Harvard Medical School and the Novartis Institutes for BioMedical Research has created an open-source machine learning tool that identifies proteins associated with drug side effects.

18 Jun 2020

Lonza and CELLINK collaborate to advance complete 3D cell culture workflows

Lonza and the Swedish company CELLINK have partnered to offer a comprehensive 3-dimensional bioprinting solution designed to optimize and increase access to complete 3D cell culture workflows.

18 Jun 2020

NIST updates its database of chemical fingerprints

The National Institute of Standards and Technology has updated its database of chemical fingerprints, called mass spectra, that are used to identify unknown chemical compounds.

17 Jun 2020

NJIT researchers develop new efficient method for targeted protein analysis

Researchers at New Jersey Institute of Technology in collaboration with Ohio University and Merck & Co. Inc. recently developed a new efficient method for targeted protein analysis -- one they say could speed up processes for disease testing, drug discovery and vaccine development.

17 Jun 2020

Researchers receive federal funding to rapidly repurpose FDA-approved drugs for COVID-19

Researchers at the University of Maryland School of Medicine will be partnering on an agreement funded by the federal government's Defense Advanced Research Projects Agency (DARPA) to rapidly test hundreds of drugs, approved and marketed for other conditions, to see whether any can be repurposed to prevent or treat COVID-19.

16 Jun 2020

New $26.9 million project aims to create better psychiatric drugs without side effects

Rapidly acting drugs to treat depression, anxiety, or substance abuse without side effects do not exist. Researchers led by Bryan L. Roth, MD, PhD, the Michael Hooker Distinguished Professor of Pharmacology at the UNC School of Medicine, are trying to change that.

16 Jun 2020

Drug Discovery News and Research

Further Reading

Irresistin: a ‘poison arrow’ to defeat antibiotic resistance

Bioengineered uterine tissue can support normal pregnancies, study shows

Clinically approved drugs could disrupt SARS-CoV-2 from hijacking cells

3D structure of Aβ protein assemblies reveals a new mechanism of toxicity

Sanford Burnham Prebys announces research agreement with Lilly to identify COVID-19 antibodies

WFIRM and Oracle Health Sciences team up to pair Body-on-a-Chip with data analytics

International study uncovers three molecules with potential for treating epilepsy

Sygnature Discovery strengthens senior management team with appointment of Dr Paul Overton

New virtual incubator can catalyze early-stage drug discovery and development

UK announces research partnership with Atomwise to explore potential COVID-19 therapies

Prior infection provides protection against SARS-CoV-2 virus in hamsters

Organoids can help provide new level of accuracy in prescribing anti-cancer therapies

UQ superbug drug discoveries will be fast-tracked under international research deal

UAH researchers assess treatment efficacy of naturally occurring compounds against COVID-19

Researchers develop tool to identify proteins associated with drug side effects

Lonza and CELLINK collaborate to advance complete 3D cell culture workflows

NIST updates its database of chemical fingerprints

NJIT researchers develop new efficient method for targeted protein analysis

Researchers receive federal funding to rapidly repurpose FDA-approved drugs for COVID-19

New $26.9 million project aims to create better psychiatric drugs without side effects

eBook: Advancing neurodegenerative research with iPSC-derived microglia models eBook

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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