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DNA, or deoxyribonucleic acid, is the hereditary material in humans and almost all other organisms. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).

NMR Spectroscopy for In-Vitro Diagnostic Research

An interview with Dr. Manfred Spraul, discussing AVANCE, an advanced NMR spectrometer that is being applied to the fields of epidemiology and metabolomics.

From Bruker BioSpin - NMR, EPR and Imaging 2 Jul 2014

UCLA receives $7.2 million grant to develop ways to diagnose rare genetic disorders

The David Geffen School of Medicine at UCLA is one of six institutions nationwide chosen by the National Institutes of Health to join their effort in tackling the most difficult-to-solve medical cases and develop ways to diagnose rare genetic disorders.

1 Jul 2014

Aspirin, smoking influence aging processes of female genome connected to colorectal cancer

The risk of developing cancer increases with age. Factors like smoking and regular aspirin use also affect the risk of cancer - although in the opposite sense. Researchers from the University of Basel were now able to show that aspirin use and smoking both influence aging processes of the female genome that are connected to colorectal cancer.

1 Jul 2014

Reticular drusen linked to AMD progression

Four percent of individuals aged 49 years and above will develop reticular drusen over 15 years of follow-up, Australian study findings suggest, with the incidence higher in those with age-related macular degeneration risk factors.

1 Jul 2014

New approach may help develop more effective immunotherapy for metastatic melanoma

A new approach demonstrated that the recognition of unique cancer mutations appeared to be responsible for complete cancer regressions in two metastatic melanoma patients treated with a type of immunotherapy called adoptive T-cell therapy.

1 Jul 2014

A*STAR scientists pioneered a molecular connection between obesity and diabetes

Scientists from the Institute of Molecular and Cell Biology, a research institute under the Agency for Science, Technology and Research, have discovered that obese individuals lack a protein that is essential for regulating blood glucose levels, causing them to face higher risks of developing diabetes.

1 Jul 2014

Genetic variants alter chance of sunitinib dose reduction

Scientists have identified genetic variants that reduce the likelihood of sunitinib dose reduction in patients with metastatic renal cell carcinoma.

30 Jun 2014

UK's TSB provides £347,000 for project to optimise gene library assembly technology

Today, Monday 30th June, 2014, Isogenica, Cambridge UK and Imperial College London secure funding from the Technology Strategy Board (TSB), the UK's innovation agency, for a £347,000 project to optimise a gene library assembly technology for potential use in synthetic biology.

30 Jun 2014

Age of sperm donor does not affect outcome in terms of live birth

Despite emerging evidence of a decline in sperm quality with increasing age, an analysis of every first fertility treatment cycle performed in the UK using sperm donation shows that outcome in terms of live birth is not affected by the age of the sperm donor.

30 Jun 2014

Study of mutations in cell's DNA help trace its life history

Researchers have developed new methods to trace the life history of individual cells back to their origins in the fertilised egg. By looking at the copy of the human genome present in healthy cells, they were able to build a picture of each cell's development from the early embryo on its journey to become part of an adult organ.

30 Jun 2014

Phase III TAS-102 study for metastatic colorectal cancer shows improved survival

The new combination agent TAS-102 is able to improve overall survival compared to placebo in patients whose metastatic colorectal cancer is refractory to standard therapies, researchers said at the ESMO 16th World Congress on Gastrointestinal Cancer in Barcelona.

30 Jun 2014

patients with KRAS wild-type MCRC can benefit from Cetuximab Or Bevacizumab With Combi Chemo Equivalent For patients with KRAS wild-type MCRC

For patients with KRAS wild-type untreated colorectal cancer, adding cetuximab or bevacizumab to combination chemotherapy offers equivalent survival, researchers said at the ESMO 16th World Congress on Gastrointestinal Cancer in Barcelona.

30 Jun 2014

Taiho Oncology presents TAS-102 Phase III RECOURSE trial results in mCRC patients

Taiho Oncology, Inc., a subsidiary of Taiho Pharmaceutical Co., Ltd. (Japan), announced today detailed findings from its global Phase III RECOURSE trial of TAS-102 (nonproprietary names: trifluridine and tipiracil hydrochloride), an oral combination anticancer drug.

28 Jun 2014

Non-Hodgkin lymphoma subgroups found to have different survival rates

A Mayo Clinic-led group of researchers has discovered three subgroups of a single type of non-Hodgkin lymphoma that have markedly different survival rates. These subgroups could not be differentiated by routine pathology but only with the aid of novel genetic tests, which the research team recommends giving to all patients with ALK-negative anaplastic large-cell lymphoma (ALCL). Findings are published in the journal Blood.

27 Jun 2014

Personalized antibiotic therapy can help fight antibiotic-resistant infections

The Centers for Disease Control and Prevention warned last fall that the U.S. faces "potentially catastrophic consequences" if it doesn't act quickly to combat the growing threat of antibiotic-resistant infections, which kill about 23,000 Americans a year.

27 Jun 2014

Cancer drug shows promise in treating blood cell disorders

Scientists working to make gene therapy a reality have solved a major hurdle: how to bypass a blood stem cell's natural defenses and efficiently insert disease-fighting genes into the cell's genome.

27 Jun 2014

Scientists report first successful step toward vaccine that targets mutation in brain cancer

Astrocytomas and oligodendrogliomas are subtypes of a brain cancer called 'glioma'. These incurable brain tumors arise from glial cells, a type of support cell found in the central nervous system.

26 Jun 2014

Current sequencing protocols overlook DNA crucial to bacterial virulence

Genomic sequencing is supposed to reveal the entire genetic makeup of an organism. For infectious disease specialists, the technology can be used to analyze a disease-causing bacterium to determine how much harm it is capable of causing and whether or not it will be resistant to antibiotics.

26 Jun 2014

Researchers compare genome sequences of malaria vectors to investigate insecticide resistance

Researchers from LSTM have exploited a natural experiment created by insecticidal pressure to determine how the most important malaria vectors - A. gambiae s.s. and A. coluzzii - respond rapidly to environmental change.

26 Jun 2014

USAMRIID scientists propose new standards to sequence viral genomes

Scientists at the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) have proposed a set of standards aimed at developing a common "language" among investigators working to sequence viral genomes and characterize viral stocks.

26 Jun 2014

DNA News and Research

Further Reading

NMR Spectroscopy for In-Vitro Diagnostic Research

UCLA receives $7.2 million grant to develop ways to diagnose rare genetic disorders

Aspirin, smoking influence aging processes of female genome connected to colorectal cancer

Reticular drusen linked to AMD progression

New approach may help develop more effective immunotherapy for metastatic melanoma

A*STAR scientists pioneered a molecular connection between obesity and diabetes

Genetic variants alter chance of sunitinib dose reduction

UK's TSB provides £347,000 for project to optimise gene library assembly technology

Age of sperm donor does not affect outcome in terms of live birth

Study of mutations in cell's DNA help trace its life history

Phase III TAS-102 study for metastatic colorectal cancer shows improved survival

patients with KRAS wild-type MCRC can benefit from Cetuximab Or Bevacizumab With Combi Chemo Equivalent For patients with KRAS wild-type MCRC

Taiho Oncology presents TAS-102 Phase III RECOURSE trial results in mCRC patients

Non-Hodgkin lymphoma subgroups found to have different survival rates

Personalized antibiotic therapy can help fight antibiotic-resistant infections

Cancer drug shows promise in treating blood cell disorders

Scientists report first successful step toward vaccine that targets mutation in brain cancer

Current sequencing protocols overlook DNA crucial to bacterial virulence

Researchers compare genome sequences of malaria vectors to investigate insecticide resistance

USAMRIID scientists propose new standards to sequence viral genomes

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