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New vessel-chip deployment platform holds promise for personalized drug testing

The pharmaceutical drug development and approval process is a multi-step undertaking that requires a plethora of testing before reaching the market.

31 May 2024

Stress and pain linked to worse outcomes in HER2-positive breast cancer patients

Secondary analyses of a phase 3 clinical trial have revealed that breast cancer patients who reported high levels of pain and stress were more likely than their study peers to experience worse invasive disease-free survival (iDFS) and worse overall survival (OS).

31 May 2024

Mediterranean diet linked to lower mortality risk in women

Investigators from Brigham and Women's Hospital identified and assessed underlying mechanisms that may explain the Mediterranean diet's 23 percent reduction in all-cause mortality risk for American women.

31 May 2024

RNA virus hiding in common human parasite may exacerbate toxoplasmosis

An international team led by researchers at the University of Toronto has found a new RNA virus that they believe is hitching a ride with a common human parasite.

31 May 2024

Good communication between fathers and adolescents influences physical activity levels

A doctoral dissertation from the University of Jyväskylä, Finland, found that having difficulties in talking with one's father predicted a decrease in physical activity and the maintenance of low physical activity between adolescence and young adulthood.

31 May 2024

New method enhances the efficacy of bispecific antibody therapies in treating solid tumors

Professor Seung-Woo Lee and PhD candidate Kun-Joo Lee from the Department of Life Sciences at Pohang University of Science and Technology (POSTECH), in collaboration with NeoImmuneTech Director Donghoon Choi and Professors Dae Hee Kim and Sun Shim Choi from Kangwon National University, have revealed a groundbreaking method to significantly enhance the efficacy of bispecific antibody therapies in treating solid tumors.

31 May 2024

Life's Essential 8: key to reducing heart disease and mortality through epigenetics

Whether DNA methylation-based epigenetic age biomarkers mediate the associations between LE8 score and risks of CVD, CVD-specific mortality, and all-cause mortality.

31 May 2024

Is there an association between fatherhood and cardiovascular outcomes?

Associations between fatherhood and cardiovascular health (CVH), disease (CVD), and mortality.

31 May 2024

Single infusion of engineered T-cells achieves lasting asthma remission in mice

Researchers demostrate that durable asthma remission can be achieved with engineered and long-lived CAR T-cell treatment in mice.

31 May 2024

RNA interference agent plozasiran targets APOC3 for effective mixed hyperlipidemia treatment

Researchers evaluate the efficacy of plazosiran treatment on fasting triglyceride levels in adult patients with mixed hyperlipidemia.

31 May 2024

Researchers uncover two classes of genetic causes for pediatric chordoma

Little is known about the genetics and biology of chordoma, a rare and aggressive bone tumor. Chordomas occur in approximately one in a million people in the U.S. a year and only five percent of these are in children.

30 May 2024

Notre Dame study identifies high-risk population for CAUTIs due to fibrinolytic deficiencies

Urinary catheters are required for nearly every surgical procedure. However, a major challenge for the health care industry is predicting who may develop catheter-associated urinary tract infections (CAUTIs) and when these infections may lead to death.

30 May 2024

Dana-Farber study exposes hidden disparities in cancer care experiences

Four teams of Dana-Farber Cancer Institute investigators have found that people experience discrimination and bias in different ways and in more realms of cancer care than previously understood.

30 May 2024

New recommendations designed to reframe the evaluation of in vitro diagnostic tests

Recommendations designed to reframe the evaluation of in vitro diagnostic tests have been published today by the Royal Statistical Society in its Series A journal.

30 May 2024

Miniaturized CRISPR protein opens door for gene therapy with adeno-associated virus

Researchers have developed a novel version of a key CRISPR gene-editing protein that shows efficient editing activity and is small enough to be packaged within a non-pathogenic virus that can deliver it to target cells.

30 May 2024

Engineered immunogens show promise in inducing HIV broadly neutralizing antibodies

Using a combination of cutting-edge immunologic technologies, researchers have successfully stimulated animals' immune systems to induce rare precursor B cells of a class of HIV broadly neutralizing antibodies (bNAbs).

30 May 2024

Three-year study shows lingering effects of COVID-19

New findings on long COVID -; long-term effects on health experienced by many who have had COVID-19 -; present a good-news, bad-news situation, according to a study at Washington University School of Medicine in St. Louis and the Veterans Affairs St. Louis Health Care system.

30 May 2024

Genomic evidence of prenatal origins in childhood acute myeloid leukemia

A team of researchers from the Institute of Oncology of the University of Oviedo (IUOPA), the Josep Carreras leukemia Research Institute, the University of Barcelona and the Centre for Biomedical Research in Cancer Network (CIBERONC) have demonstrated that some childhood leukemia originate during embryonic development, although they do not manifest after a few months after birth.

30 May 2024

Understanding the long-term effects and safety of testosterone therapy in transgender men

Transgender individuals often face unique challenges in aligning their physical bodies with their true gender identity.

30 May 2024

How tight binding between immune cells dictates T cell cancer-fighting ability

Immunotherapy, treatments that reinvigorate immune cells' anti-cancer activity or reprogram T cells to target cancer, has shown promise in treating leukemias but has not yet been realized in solid tumors.

30 May 2024

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Blood News and Research

New vessel-chip deployment platform holds promise for personalized drug testing

Stress and pain linked to worse outcomes in HER2-positive breast cancer patients

Mediterranean diet linked to lower mortality risk in women

RNA virus hiding in common human parasite may exacerbate toxoplasmosis

Good communication between fathers and adolescents influences physical activity levels

New method enhances the efficacy of bispecific antibody therapies in treating solid tumors

Life's Essential 8: key to reducing heart disease and mortality through epigenetics

Is there an association between fatherhood and cardiovascular outcomes?

Single infusion of engineered T-cells achieves lasting asthma remission in mice

RNA interference agent plozasiran targets APOC3 for effective mixed hyperlipidemia treatment

Researchers uncover two classes of genetic causes for pediatric chordoma

Notre Dame study identifies high-risk population for CAUTIs due to fibrinolytic deficiencies

Dana-Farber study exposes hidden disparities in cancer care experiences

New recommendations designed to reframe the evaluation of in vitro diagnostic tests

Miniaturized CRISPR protein opens door for gene therapy with adeno-associated virus

Engineered immunogens show promise in inducing HIV broadly neutralizing antibodies

Three-year study shows lingering effects of COVID-19

Genomic evidence of prenatal origins in childhood acute myeloid leukemia

Understanding the long-term effects and safety of testosterone therapy in transgender men

How tight binding between immune cells dictates T cell cancer-fighting ability

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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