Drug Discovery News and Research

RSS

The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

Scientist proposes geroprotective strategies to reduce lethality of COVID-19 in the elderly

The Biogerontology Research Foundation, a registered UK charity supporting and promoting aging and longevity research worldwide since 2008, today announced the publication of a paper titled "Geroprotective and senoremediative strategies to reduce the comorbidity, infection rates, severity, and lethality in gerophilic and gerolavic infections" in the leading journal Aging.

6 Apr 2020

Using marine natural product to inhibit cervical cancer

A sponge found in Manado Bay, Indonesia, makes a molecule called manzamine A, which stops the growth of cervical cancer cells, according to a recent publication in the Journal of Natural Products submitted by researchers at the Medical University of South Carolina and their collaborators.

6 Apr 2020

Horizon Discovery expands cell-based CRISPR screening services

Horizon Discovery Group plc, today announced the addition of an arrayed CRISPR knockout screening service for primary human B cells.

From Revvity 6 Apr 2020

IRB Barcelona and Amazon join forces to develop computational tool in the fight against COVID-19

There are currently more than 10,000 scientific articles related to coronavirus infections. In fact, in recent weeks, research to combat COVID-19 has accelerated, and more than 4,000 new academic papers have been published on potential vaccines, therapies, and treatments.

3 Apr 2020

Investigating Human Disease with Mass Spectrometry-based Proteomics

Dr. Andrew Webb describes how his lab uses mass spectrometry-based techniques to understand the role of post-translational modifications in human disease.

From Bruker Life Sciences Mass Spectrometry 3 Apr 2020

Excess cardiac myosin worsens damage to heart tissue during a heart attack

A prevalent heart protein known as cardiac myosin, which is released into the body when a person suffers a heart attack, can cause blood to thicken or clot--worsening damage to heart tissue, a new study shows.

2 Apr 2020

New microfluidic chip can mimic hypoxic conditions after a heart attack

Researchers led by biomedical engineers at Tufts University invented a microfluidic chip containing cardiac cells that is capable of mimicking hypoxic conditions following a heart attack - specifically when an artery is blocked in the heart and then unblocked after treatment.

30 Mar 2020

Fast-acting anti-malarial compound shows promise in first clinical trial

A fast-acting anti-malarial compound discovered at St. Jude Children's Research Hospital was well tolerated and showed promising anti-malarial effects in the first study in humans.

27 Mar 2020

FDA approves immune-modulating therapy for treatment of multiple sclerosis

The U.S. Food and Drug Administration has approved ozanimod, an immune-modulating therapy invented at Scripps Research, for the treatment of adults with relapsing forms of multiple sclerosis.

26 Mar 2020

Why Primary Cells Are Important for In Vitro ADME-Tox Studies

Lonza is a large, multinational corporation serving the entire pharmaceutical product development and manufacturing pipeline, from non-clinical research products to final dosage and delivery solutions.

From Lonza 26 Mar 2020

Gero uses AI platform to identify potential anti-COVID-19 drugs

Gero, the leader in AI-driven drug discovery, has used its AI platform to identify the potential anti-COVID-19 drugs. Six of them have been approved, three were withdrawn, and the other nine have been already tested in clinical trials for other indications.

25 Mar 2020

Study: Bacterial protein fragment instigates lung tissue death in pulmonary fibrosis

A bacterial protein fragment instigates lung tissue death in pulmonary fibrosis, a mysterious disease affecting millions of people worldwide, according to a new study from researchers at the University of Illinois at Urbana-Champaign and Mie University in Japan.

24 Mar 2020

Researchers rejuvenate aged human cells with stem cell technology

Scientists have used stem cell technology to force old human cells to rejuvenate, reversing the impact that aging has on cells.

24 Mar 2020

Biogelx announce Alison Clayton as new CEO

Biogelx, a Scottish biomaterials company is pleased to announce the appointment of Alison Clayton as their new Chief Executive Officer.

24 Mar 2020

Old human cells regain youthful strength after rejuvenating protein treatment, study finds

Old human cells return to a more youthful and vigorous state after being induced to briefly express a panel of proteins involved in embryonic development, according to a new study by researchers at the Stanford University School of Medicine.

24 Mar 2020

Melinjo seed extract may improve obesity and diabetes

In Southeast Asia, the fruit, flowers, and leaves of Indonesia's "Melinjo" tree are traditional foods.

23 Mar 2020

Discovery shows a novel opportunity for DOT1L inhibitors in cancer treatment

Oncotarget Volume 11, Issue 11 reported that in order to understand the molecular mechanism of the dependency in MM, the research team examined gene expression changes upon DOT1L inhibition in sensitive and insensitive cell lines and discovered that genes belonging to the endoplasmic reticulum stress pathway and protein synthesis machinery were specifically suppressed in sensitive cells.

22 Mar 2020

Researchers invent new method to map sugar structures of blood-thinning drug

The blood-thinning drug heparin is used all over the world. But, the underlying sugar structures of heparin and the wider family of heparan sulfate sugars in cells have not been fully mapped.

22 Mar 2020

DSI alumni use computational design to quickly discover treatments for COVID-19

Two graduates of the Data Science Institute at Columbia University are using computational design to quickly discover treatments for the coronavirus.

21 Mar 2020

Organ-Chips provide human-relevant insights into diseases and toxicity mechanisms

Organs-on-Chips technology has entered the mainstream and has reached 150 installations for use by researchers across many industries, including 10 of the top 25 biopharmaceutical companies, as well as leading international academic research centers and U.S. government laboratories, including the U.S. FDA through a collaborative agreement and the U.S. Army.

20 Mar 2020