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Adrenomedullin could serve as biomarker, therapeutic target in disorders caused by leaky blood vessels

Disorders caused by a leaky vasculature are more common than most people think. Despite ICU treatment, one third of the 27 million patients globally that suffer from sepsis, and up to 20% of the more than 5 million US patients with congestive heart failure die every year from their condition.

5 Jan 2018

Precision editing of gut bacteria reduces inflammation in mouse model of colitis

UT Southwestern Medical Center researchers have used precision editing of the bacterial populations in the gut to prevent or reduce the severity of inflammation in a mouse model of colitis.

5 Jan 2018

Specific bacteria in the intestines can improve response rate to cancer immunotherapy

In the Jan. 5, 2018 issue of Science, researchers from the University of Chicago Medicine show that specific strains of commensal bacteria – the swarms of microorganisms naturally dwelling in the intestines – can improve the response rate to immunotherapy for patients being treated for advanced melanoma.

5 Jan 2018

UC Davis expert expresses caution on genetically engineered HSCs

In a commentary published in the Jan. 4 issue of the New England Journal of Medicine, UC Davis researcher William Murphy expressed cautious optimism about efforts to genetically engineer hematopoietic stem cells (HSCs) to temporarily resist cell death during transplantation.

4 Jan 2018

Sleeping sickness actually caused by acceleration of biological clocks

Sleeping sickness could use a more encompassing moniker. An international study from the O'Donnell Brain Institute shows one of Africa's most lethal diseases is actually a circadian rhythm disorder caused by the acceleration of biological clocks controlling a range of vital functions besides sleep.

4 Jan 2018

MGH study points toward potential strategy for treating X-linked disorders

A study from a team of Massachusetts General Hospital (MGH) investigators points toward a potential strategy for treating X-linked disorders - those caused by mutations in the X chromosome - in females.

4 Jan 2018

Researchers optimize method to increase resolution of proteomic analysis

One of the key challenges of proteomics, the study of all proteins expressed by a cell or organism, is managing to distinguish between molecules that are structurally different yet have the same mass.

4 Jan 2018

Study illustrates the role of alcohol in causing damage to DNA and increased cancer risk

A new study conducted by a group of researchers at MRC Laboratory of Molecular Biology, Cambridge revealed the significant role of alcohol in causing damage to DNA in stem cells and thereby increasing cancer risks. The study was funded by Cancer Research UK and the results were published in Nature.

4 Jan 2018

Scientists show how alcohol exposure leads to permanent genetic damage

Scientists have shown how alcohol damages DNA in stem cells, helping to explain why drinking increases your risk of cancer, according to research part-funded by Cancer Research UK and published in Nature today (Wednesday).

4 Jan 2018

Genetic labeling helps researchers track behavior of blood cells

By tagging bone marrow cells of mice with a genetic label, or barcode, researchers were able to track and describe the family tree of individual blood cells as they form in their natural environment.

4 Jan 2018

Dietary sugar may contribute to increasing frequency, severity of bacterial epidemics

The increasing frequency and severity of healthcare-associated outbreaks caused by bacterium Clostridium difficile have been linked to the widely used food additive trehalose.

3 Jan 2018

New total-body PET scanner could revolutionize patient diagnosis and care

The new total-body PET/CT scanner could revolutionize our understanding and treatment of disease through analysis of better imaging data from the whole body.

3 Jan 2018

Study suggests potential means of stalling or even reversing diabetes-related blindness

Johns Hopkins researchers have discovered a cell signaling pathway in mice that triggers vision loss in patients with diabetic retinopathy and retinal vein occlusion – diseases characterized by the closure of blood vessels in the retina, leading to blindness.

3 Jan 2018

Researchers discover way to enhance effectiveness and safety of sonogenetics

Researchers at Duke University have discovered a way to enhance the effectiveness and safety of sonogenetics or ultrasonic modulation, emerging techniques that use sound waves to control the behavior of individual neurons or to promote tissue growth and wound healing in other cells.

3 Jan 2018

New cholesterol calculation method could eliminate need for routine fasting

In a direct comparison study, Johns Hopkins researchers have added to evidence that a newer method of calculating so-called "bad cholesterol" levels in the blood is more accurate than the older method in people who did not fast before blood was drawn.

2 Jan 2018

Experimental diabetes drugs can make cancer cells vulnerable to chemotherapy agents

Scientists at Dana-Farber Cancer Institute have shown that experimental diabetes drugs can make cancer cells more vulnerable to traditional chemotherapy agents, and they say such combinations should be explored to potentially improve outcomes for cancer patients.

2 Jan 2018

Novel nanomedicine prolongs survival of pancreatic tumor-bearing mice

A new Tel Aviv University study pinpoints the inverse correlation between a known oncogene -- a gene that promotes the development of cancer -- and the expression of an oncosuppressor microRNA as the reason for extended pancreatic cancer survival.

2 Jan 2018

Arterial stiffness improves with high doses of vitamin D supplementation, study finds

In just four months, high-doses of vitamin D reduce arterial stiffness in young, overweight/obese, vitamin-deficient, but otherwise still healthy African-Americans, researchers say.

2 Jan 2018

Genes in Space-3 team identifies microbes in real time aboard the space station

Being able to identify microbes in real time aboard the International Space Station, without having to send them back to Earth for identification first, would be revolutionary for the world of microbiology and space exploration.

29 Dec 2017

UAB study shows missense mutations as key risk factor for severe symptoms of neurofibromatosis type 1

Research led by Ludwine Messiaen, Ph.D., professor of genetics at the University of Alabama at Birmingham, shows that missense mutations in a cluster of just five codons in the NF1 gene are an important risk factor for severe symptoms of the genetic disease neurofibromatosis type 1.

28 Dec 2017

Laboratory News and Research

Adrenomedullin could serve as biomarker, therapeutic target in disorders caused by leaky blood vessels

Precision editing of gut bacteria reduces inflammation in mouse model of colitis

Specific bacteria in the intestines can improve response rate to cancer immunotherapy

UC Davis expert expresses caution on genetically engineered HSCs

Sleeping sickness actually caused by acceleration of biological clocks

MGH study points toward potential strategy for treating X-linked disorders

Researchers optimize method to increase resolution of proteomic analysis

Study illustrates the role of alcohol in causing damage to DNA and increased cancer risk

Scientists show how alcohol exposure leads to permanent genetic damage

Genetic labeling helps researchers track behavior of blood cells

Dietary sugar may contribute to increasing frequency, severity of bacterial epidemics

New total-body PET scanner could revolutionize patient diagnosis and care

Study suggests potential means of stalling or even reversing diabetes-related blindness

Researchers discover way to enhance effectiveness and safety of sonogenetics

New cholesterol calculation method could eliminate need for routine fasting

Experimental diabetes drugs can make cancer cells vulnerable to chemotherapy agents

Novel nanomedicine prolongs survival of pancreatic tumor-bearing mice

Arterial stiffness improves with high doses of vitamin D supplementation, study finds

Genes in Space-3 team identifies microbes in real time aboard the space station

UAB study shows missense mutations as key risk factor for severe symptoms of neurofibromatosis type 1

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