Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

New molecular 'fishing' technology can find individual molecules in blood

Like finding a needle in a haystack, Liviu Movileanu can find a single molecule in blood. Movileanu, professor at Syracuse University, and recently graduated Ph.D. student Avinash Thakur will present their research on Monday, February 17 at the 64th Annual Meeting of the Biophysical Society in San Diego, California.

16 Feb 2020

Scientists create world’s first model of pituitary disease using human iPS cells

Researchers at Kobe University's Graduate School of Medicine have developed the world's first congenital pituitary hypoplasia model using patient-derived iPS cells.

14 Feb 2020

Novel drug combination discovered to induce high rates of human beta cell proliferation

Researchers at the Icahn School of Medicine at Mount Sinai have discovered a novel combination of two classes of drugs that, together, cause the highest rate of proliferation ever observed in adult human beta cells- the cells in the pancreas that produce insulin- without harming most other cells in the body.

12 Feb 2020

New approach for organic synthesis may apply to drug discovery

After helping develop a new approach for organic synthesis -- carbon-hydrogen functionalization -- scientists at Emory University are now showing how this approach may apply to drug discovery

12 Feb 2020

Study provides evidence of aerosol exposure to microcystins among coastal residents

Florida has experienced numerous harmful algal blooms in recent years, including blue-green algae and their toxins in 2016 and 2018. Despite their intensity and frequency, there is scant data on human exposure to these blooms and concentrations of the toxins they produce in tissues of exposed individuals.

12 Feb 2020

Novel injectable drug for faster healing of broken bones moves closer to clinical trials

One in three adults aged 60 and over suffering from a hip fracture dies within one year. Now, a Purdue University-affiliated startup is moving closer to the start of clinical trials for a novel injectable drug that is targeted to heal broken bones faster and strengthen weak bones.

11 Feb 2020

Protein Data Bank archive releases new coronavirus protease structure

The Protein Data Bank archive, which contains more than 160,000 3D structures for proteins, DNA, and RNA, this month released a new Coronavirus protease structure following the recent coronavirus outbreak, an ongoing viral epidemic primarily affecting mainland China that now threatens to spread to populations in other parts of the world.

10 Feb 2020

Powerful vaccine could boost the effectiveness of cancer immunotherapy

Supercharging the mutation rate in cancer cells can create a powerful vaccine that is able to boost the effectiveness of immunotherapy, a major new study reports.

9 Feb 2020

Purdue-developed 'fluorescent markers' begin Phase 3 clinical trials

On Target Laboratories Inc., a privately held biotechnology company developing the use of Purdue University-discovered fluorescent markers to target and illuminate cancer during surgery, has announced the results of a multi-institutional Phase 2 clinical trial in which outcomes were improved for 26% of patients undergoing pulmonary resection for non-small-cell lung cancer.

6 Feb 2020

Re-engineered plant compound reduces morphine-seeking behaviors in mice

The abuse of prescription and illegal opioids, such as morphine and heroin, is a major problem in the U.S., with devastating public health, economic and social consequences.

5 Feb 2020

Study underscores the need for more precise rare disease definitions

Some diseases are like black swans. They occur so rarely that many physicians never encounter them in their clinical practice, complicating efforts to treat them.

5 Feb 2020

FDA gives clearance to IND application for Calibr's 'switchable' CAR-T cell therapy

Calibr, the drug discovery and development division of Scripps Research, today announced that the U.S. Food and Drug Administration has given clearance to the Investigational New Drug (IND) application for Calibr's "switchable" CAR-T cell therapy, which is being evaluated for the treatment of certain cancers, including relapsed/refractory B-cell malignancies such as non-Hodgkin lymphoma and chronic lymphocytic leukemia.

3 Feb 2020

Potential new biomarker for vascular dementia identified

Vascular dementia is caused by a defect on blood flow arrival to the brain, which consequently generates neuronal damage.

30 Jan 2020

New target protein linked to regulation, movement of tumor-associated macrophages

Developing a therapy to combat cancer remains one of the most difficult challenges in medical research. Cancer owes its notorious identity to the fact that the cancer cells use the host's own immune system to grow and spread, ultimately becoming deadly.

30 Jan 2020

ERA4TB to transform the development of new therapies for tuberculosis

With a team of more than thirty public and private organisations and a budget over 200 million euro, ERA4TB aims to radically transform the way in which new therapies are developed for the treatment of tuberculosis.

30 Jan 2020

Novel inhibitor to fight metastatic prostate cancer shows promise

When prostate cancer spreads it is often a deadly disease, but now a Stony Brook University-led research team believes a new approach that inhibits a specific fatty acid binding protein (FABP) may be the key to halting disease progression.

30 Jan 2020

Robotic search for drugs that block sperm motility

The hunt for the first male contraceptive pill is on, and scientists at Dundee University may have the needed tool to find it – a robotic screening system.

29 Jan 2020

Researchers create new brain cancer model using genetically engineered pluripotent stem cells

Using genetically engineered human pluripotent stem cells, University of California San Diego School of Medicine researchers created a new type of cancer model to study in vivo how glioblastoma, the most common and aggressive form of brain cancer, develops and changes over time.

29 Jan 2020

Nicoya launches groundbreaking new SPR system to accelerate drug discovery

Nicoya, a leading provider of advanced analytical instruments for the biotechnology and pharmaceutical industries, today announced the launch of Alto, the world’s first fully-automated, high-throughput benchtop surface plasmon resonance (SPR) system.

From Nicoya Lifesciences 28 Jan 2020

Benchling launches new solution to help life science companies maximize lab automation investments

Benchling, the leading life sciences R&D cloud platform, today announced the launch of Benchling for Lab Automation, a new solution to help life sciences companies maximize lab automation investments.

From Society for Laboratory Automation and Screening (SLAS2020) 28 Jan 2020

Drug Discovery News and Research

Further Reading

New molecular 'fishing' technology can find individual molecules in blood

Scientists create world’s first model of pituitary disease using human iPS cells

Novel drug combination discovered to induce high rates of human beta cell proliferation

New approach for organic synthesis may apply to drug discovery

Study provides evidence of aerosol exposure to microcystins among coastal residents

Novel injectable drug for faster healing of broken bones moves closer to clinical trials

Protein Data Bank archive releases new coronavirus protease structure

Powerful vaccine could boost the effectiveness of cancer immunotherapy

Purdue-developed 'fluorescent markers' begin Phase 3 clinical trials

Re-engineered plant compound reduces morphine-seeking behaviors in mice

Study underscores the need for more precise rare disease definitions

FDA gives clearance to IND application for Calibr's 'switchable' CAR-T cell therapy

Potential new biomarker for vascular dementia identified

New target protein linked to regulation, movement of tumor-associated macrophages

ERA4TB to transform the development of new therapies for tuberculosis

Novel inhibitor to fight metastatic prostate cancer shows promise

Robotic search for drugs that block sperm motility

Researchers create new brain cancer model using genetically engineered pluripotent stem cells

Nicoya launches groundbreaking new SPR system to accelerate drug discovery

Benchling launches new solution to help life science companies maximize lab automation investments

eBook: Essential guide to organoids in drug discovery eBook

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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